“…RT-induced valvulopathies are associated with cardiopulmonary disorders such as mediastinal and pulmonary fibrosis, constrictive pericarditis, coronary disease, porcelain aorta, and extensive valve calcification which incurs an elevated surgical risk that is not predicted by standard surgical risk scoring systems ( 7 ). Likewise, the effects of RT on valves are usually extensive, and adjacent structures, such as subvalvular apparatus, annulus, and especially the aortomitral curtain ( 7 ), are commonly involved, and higher thickening is a robust predictor of mortality ( 8 ). Mitral and aortic valves are usually affected simultaneously, and even if there is only moderate disease in one of them, it is recommended that both valves be replaced because there is a rapid progression and the very high risk of a potential reoperation.…”