Outcomes of Breast Cancer (Invasive Lobular and Ductal Carcinoma) Treated with Boost Intraoperative Electron Radiotherapy Versus Conventional External Beam Radiotherapy

Moayeri, Hassan; Akbari, Mohammad Esmaeil; Nafissi, Nahid; Mahdavi, Seied Rabi; Salati, Azam; Khayamzade, Maryam; Shormeij, Zeinab; Shakeri, Jafar; Nabatzadeh, Mojgan; Shahani, Minoo; Kiaee, Marzieh Sadat; Noorian, Sajad

doi:10.5812/ijcm.84850

Cited by 3 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the same time, there is substantial evidence supporting the efficacy of IORT 23 , 28 . Likewise, trials have shown that adjuvant radiotherapy controls the loco-regional recurrence 7 , 29 and has an abscopal effect by reducing the risk of distant recurrence 24 , 25 , 30 , 31 . Our previous proteomic and transcriptomic study on the samples of tumor bed before and after IORT illustrated many gene expression modifications that enriched in pathways related to cell growth, survival, program cell death, and cell cycle arrest 14 .…”

Section: Discussionmentioning

confidence: 99%

“…A recent study, which compared the outcome following application of full dose electron beam IORT in 216 early breast cancer patients and 323 external-beam-irradiated cases, revealed that IORT resulted in a lower rate of local recurrence, while external beam radiotherapy resulted in a higher rate of death and systemic recurrence 6 . Furthermore, a 4-year survival study revealed a significantly lower rate of metastases and ipsilateral breast tumor recurrence in Intraoperative Electron Radiotherapy (IOERT)-treated versus conventional radiotherapy-treated patients 7 . Published data suggest that, compared with whole breast radiation therapy, treatment with IORT not only reduces the treatment time 8 but also appears to alter the microenvironment of the irradiated tumor bed.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Radiobiological effects of wound fluid on breast cancer cell lines and human-derived tumor spheroids in 2D and microfluidic culture

Jeibouei

Hojat

Mostafavi

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Intraoperative radiotherapy (IORT) could abrogate cancer recurrences, but the underlying mechanisms are unclear. To clarify the effects of IORT-induced wound fluid on tumor progression, we treated breast cancer cell lines and human-derived tumor spheroids in 2D and microfluidic cell culture systems, respectively. The viability, migration, and invasion of the cells under treatment of IORT-induced wound fluid (WF-RT) and the cells under surgery-induced wound fluid (WF) were compared. Our findings showed that cell viability was increased in spheroids under both WF treatments, whereas viability of the cell lines depended on the type of cells and incubation times. Both WFs significantly increased sub-G1 and arrested the cells in G0/G1 phases associated with increased P16 and P21 expression levels. The expression level of Caspase 3 in both cell culture systems and for both WF-treated groups was significantly increased. Furthermore, our results revealed that although the migration was increased in both systems of WF-treated cells compared to cell culture media-treated cells, E-cadherin expression was significantly increased only in the WF-RT group. In conclusion, WF-RT could not effectively inhibit tumor progression in an ex vivo tumor-on-chip model. Moreover, our data suggest that a microfluidic system could be a suitable 3D system to mimic in vivo tumor conditions than 2D cell culture.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Radiobiological effects of wound fluid on breast cancer cell lines and human-derived tumor spheroids in 2D and microfluidic culture

Jeibouei

Hojat

Mostafavi

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…We conducted a study in the cancer research center on 968 patients with breast cancer (IDC and ILC) to compare IOERT (a boost dose) with EBRT. e findings suggested that IOERT was noninferior in comparison with EBRT (P � 0.215) [19].…”

Section: Discussionmentioning

confidence: 95%

Comparison of IORT (Radical and Boost Dose) and EBRT in Terms of Disease-Free Survival and Overall Survival according to Demographic, Pathologic, and Biological Factors in Patients with Breast Cancer

Hashemi

Javadi

Akbari

et al. 2021

International Journal of Surgical Oncology

Self Cite

View full text Add to dashboard Cite

Background. The standard treatment for breast cancer is breast-conserving surgery (BCS) with radiotherapy. If external beam radiation therapy (EBRT) can be safely replaced with intraoperative radiotherapy (IORT), it will help patients to save their breast and to have equivocal or better results in DFS and overall survival (OS). Methods. A total of 2022 patients with breast cancer treated during 6 years were enrolled in the current study. A total of 657, 376, and 989 patients received EBRT, radical, and boost dose by IORT, respectively, according to the IRIORT consensus protocol. The primary endpoint was recurrence and death. The secondary endpoint was the role of variables in recurrence and death. Results. With a mean follow-up of 34.5 and 40.18 months for the IORT and EBRT groups, respectively, there was a significant difference in DFS between electron boost and X-ray boost groups ( P = 0.037 ) and the electron radical group compared with EBRT ( P = 0.025 ), but there was no significant difference between other boost and radical groups in DFS and OS. Conclusions. IORT can be a preferred treatment modality because of its noninferior outcomes, and in some special conditions, it has superior outcomes compared to EBRT, particularly in delivering radical dose with IORT.

show abstract

“…A study (2013 -2017) was performed on 968 patients with invasive breast carcinoma (ductal and lobular) and compared outcomes of EBRT with IOERT as a boost. It showed that IOERT as boost contained no inferiority in comparison with EBRT (14).…”

Section: Introductionmentioning

confidence: 96%

Comparing the Outcome of Boost Dose of Intraoperative Radiotherapy with Electron (IOERT) and Low-kV X-Ray (IOXRT) and External Beam Radiotherapy (EBRT) in Breast Cancer After Neoadjuvant Chemotherapy

et al. 2019

View full text Add to dashboard Cite

Background: In the large breast tumors or locally-advanced breast cancers, breast conserving surgery (BCS) after neoadjuvant chemotherapy (NACT) had an acceptable local control, but greater risk of recurrence. Adding boost dose radiation to whole breast radiotherapy is involved with a reduced risk of recurrence. Boost radiotherapy can be delivered in 3 methods, including (1) external beam radiotherapy (EBRT), (2) intraoperative radiotherapy with electron (IOERT), and (3) intraoperative radiotherapy with low-kV X-ray (IOXRT). Objectives: This study compared the outcomes of these 3 methods with each other. Methods: Within 60 months, 217 unselected breast cancer patients in Cancer Research Center of Shahid Beheshti were under treatment with BCS after NACT. They received boost dose radiation in 3 groups; 115 patients in the EBRT group, 39 patients IOXRT group, and 63 patients in the IOERT group. All of them received WBRT after surgery. Results: The patients had large tumors or stage 3 breast cancer. Local recurrences were 1 (2.5%) in IOXRT, 2 (3.2%) in IOERT, and 1 (0.9%) in EBRT groups. Systemic recurrences were 4 (10.3%) in IOXRT, 10 (15.9%) in IOERT, and 16 (13.9%) in EBRT groups. Deaths were 3 (7.7%) in IOXRT, 2 (3.2%) in IOERT, and 10 (6.9%) in EBRT groups. Patients with any events were 4 (10.3%) in IOXRT, 11 (17.5%) in IOERT, and 33 (15.2%) in the EBRT group. Death due to distant metastases was lower in IOERT group, but it was not significant. No significant difference was observed in disease-free survival (DFS) among 3 groups. IOXRT group had non-significant, lower events, and better DFS. Especially, in non-PCR (non-pathologic complete response) patients, multivariate COX analysis showed better outcome (DFS) in IOXRT group (HR = 0.50), although it was not significant (P = 0.53). Conclusions: Intraoperative radiotherapy (IORT or IOXRT) as tumor bed boost during BCS after NACT had at least non-inferiority compared with EBRT. In non-PCR patient, IOXRT group had non-significant better outcomes (DFS).

show abstract

Outcomes of Breast Cancer (Invasive Lobular and Ductal Carcinoma) Treated with Boost Intraoperative Electron Radiotherapy Versus Conventional External Beam Radiotherapy

Cited by 3 publications

References 30 publications

Radiobiological effects of wound fluid on breast cancer cell lines and human-derived tumor spheroids in 2D and microfluidic culture

Radiobiological effects of wound fluid on breast cancer cell lines and human-derived tumor spheroids in 2D and microfluidic culture

Comparison of IORT (Radical and Boost Dose) and EBRT in Terms of Disease-Free Survival and Overall Survival according to Demographic, Pathologic, and Biological Factors in Patients with Breast Cancer

Comparing the Outcome of Boost Dose of Intraoperative Radiotherapy with Electron (IOERT) and Low-kV X-Ray (IOXRT) and External Beam Radiotherapy (EBRT) in Breast Cancer After Neoadjuvant Chemotherapy

Contact Info

Product

Resources

About