Outcomes of an outpatient home-based prehabilitation program before pancreaticoduodenectomy: A retrospective cohort study

Chan, Kwai S.; Junnarkar, Sameer P; Wang, Bei; Tan, Yen Pin; Low, Jee Keem; Huey, Cheong Wei Terence; Shelat, Vishal G

doi:10.14701/ahbps.22-028

Cited by 3 publications

(3 citation statements)

References 39 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This value seems to be highly dependent on the surveyed population. It significantly varies among studies, encompassing rates from 20% in an european cohort ( p = 0.778) [ 15 ], reaching 35–40% ( p = 0.76) [ 16 ], up to 68% [ 17 ]. This research has been approved by IRCCS Cancer Institute “Giovanni Paolo II” of Bari ethic committee, approved on 31 December 2019, with Prot n. 806/EC and was activated with resolution no.…”

Section: Resultsmentioning

confidence: 99%

“…This study has clear limitations, mainly due to the need of confirmation in statistically powered prospective observation. Moreover, we observed a certain degree of variability in reported rates of DM prevalence, even when looking at similar populations [ 16 , 17 ]. Indeed, DM is a common comorbidity in pancreatic ductal adenocarcinoma (PDAC) patients.…”

Section: Discussionmentioning

confidence: 99%

“…One interesting finding from the TGCA cohort is that the rate of DM is greater than 50%, which is higher than the rates reported in other cohorts. For example, two studies conducted in Asian populations reported a risk of DM at around 35-40% in PDAC patients [16,33]. On the other hand, a study conducted in a European cohort reported a rate of DM at around 20% [15].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Gene Expression Comparison between Alcohol-Exposed versus Not Exposed Pancreatic Ductal Adenocarcinoma Patients Reveals a Peculiar TGFβ-Related Phenotype: An Exploratory Analysis

Doronzo¹,

Porcelli

Marziliano

et al. 2023

Medicina

View full text Add to dashboard Cite

Background: Over the past few decades, there has been much debate and research into the link between alcohol consumption and the development and progression of pancreatic ductal adenocarcinoma (PDAC). Objectives: To contribute to the ongoing discussion and gain further insights into this topic, our study analysed the gene expression differences in PDAC patients based on their alcohol consumption history. Methods: To this end, we interrogated a large publicly available dataset. We next validated our findings in vitro. Results: Our findings revealed that patients with a history of alcohol consumption showed significant enrichment in the TGFβ-pathway: a signaling pathway implicated in cancer development and tumor progression. Specifically, our bioinformatic dissection of gene expression differences in 171 patients with PDAC showed that those who had consumed alcohol had higher levels of TGFβ-related genes. Moreover, we validated the role of the TGFβ pathway as one of the molecular drivers in producing massive stroma, a hallmark feature of PDAC, in patients with a history of alcohol consumption. This suggests that inhibition of the TGFβ pathway could serve as a novel therapeutic target for PDAC patients with a history of alcohol consumption and lead to increased sensitivity to chemotherapy. Our study provides valuable insights into the molecular mechanisms underlying the link between alcohol consumption and PDAC progression. Conclusions: Our findings highlight the potential significance of the TGFβ pathway as a therapeutic target. The development of TGFβ-inhibitors may pave the way for developing more effective treatment strategies for PDAC patients with a history of alcohol consumption.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%