Outcomes of a Systems Engineering Project for K-12 Teachers

Bartus, Greg; Fisher, Frank T.

doi:10.18260/p.24550

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…More recently, large-scale CSPG digestion by direct lentiviral ChABC gene delivery into rat spinal cords demonstrated reduced cavitation volume and enhanced axon preservation. Treated rats also displayed improved sensorimotor function on behavioral and electrophysiological assessments [65]. ChABC is an exciting therapy for which the optimal modality for delivery remains to be elucidated.…”

Section: Neuroregeneration the Glial Scar Cspgs In The Glial Scarmentioning

confidence: 97%

Concise Review: Bridging the Gap: Novel Neuroregenerative and Neuroprotective Strategies in Spinal Cord Injury

Ahuja

Fehlings

2016

Stem Cells Translational Medicine

174

141

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Spinal cord injuries (SCIs) result in devastating lifelong disability for patients and their families. The initial mechanical trauma is followed by a damaging secondary injury cascade involving proapoptotic signaling, ischemia, and inflammatory cell infiltration. Ongoing cellular necrosis releases ATP, DNA, glutamate, and free radicals to create a cytotoxic postinjury milieu. Long-term regeneration of lost or injured networks is further impeded by cystic cavitation and the formation of an inhibitory glial-chondroitin sulfate proteoglycan scar. In this article, we discuss important neuroprotective interventions currently applied in clinical practice, including surgical decompression, blood pressure augmentation, and i.v. methylprednisolone. We then explore exciting translational therapies on the horizon, such as riluzole, minocycline, fibroblast growth factor, magnesium, and hypothermia. Finally, we summarize the key neuroregenerative strategies of the next decade, including glial scar degradation, Rho-ROCK inhibition, cell-based therapies, and novel bioengineered adjuncts. Throughout, we emphasize the need for combinatorial approaches to this multifactorial problem and discuss relevant studies at the forefront of translation. We conclude by providing our perspectives on the future direction of SCI research. STEM CELLS TRANSLATIONAL MEDICINE 2016;5:914-924 SIGNIFICANCESpinal cord injuries (SCIs) result in devastating, lifelong disability for patients and their families. This article discusses important neuroprotective interventions currently applied in clinical practice, including surgical decompression, blood pressure augmentation, and i.v. methylprednisolone. Translational therapies on the horizon are discussed, such as riluzole, minocycline, fibroblast growth factor, magnesium, and hypothermia. The key neuroregenerative strategies of the next decade are summarized, including glial scar degradation, Rho-ROCK inhibition, cell-based therapies, and novel bioengineered adjuncts. The need for combinatorial approaches to this multifactorial problem is emphasized, relevant studies at the forefront of translation are discussed, and perspectives on the future direction of SCI research are presented.

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Section: Neuroregeneration the Glial Scar Cspgs In The Glial Scarmentioning

confidence: 97%

Concise Review: Bridging the Gap: Novel Neuroregenerative and Neuroprotective Strategies in Spinal Cord Injury

Ahuja

Fehlings

2016

Stem Cells Translational Medicine

174

141

View full text Add to dashboard Cite

show abstract

“…20,23 Despite this interest, few studies have been able to assesses outcomes. Jain et al 24,25 use multiple-choice pre-and post-tests to assess student learning on three levels: 1) SE information content, 2) SE applications, and 3) analysis of SE concepts.…”

Section: Introductionmentioning

confidence: 99%

“…Results show a statistically significant increase in post-test scores for levels 1 and 2; however, they employ an imperfect instrument to measure SE knowledge. Other studies, including Bartus and Fisher 23 , provide qualitative descriptions of experiences for students or teachers involved in SE activities.…”

Section: Introductionmentioning

confidence: 99%