Outcomes of a Hepatitis C Screening Protocol in At-Risk Adults With Prior Cardiac Surgery

Cox, Daniel A.; Ginde, Salil; Tweddell, James S.; Earing, Michael G.

doi:10.1177/2150135114547587

Cited by 14 publications

(9 citation statements)

References 13 publications

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“…19 HCV antibodies indicating prior exposure or infection were detected in 8% of this patient cohort, and in 5% in another cohort. 19,20 Performance of cardiac operations before 1992 has been directly related to risk of HCV infection in patients with CHD. Patients with CHD who had cardiac surgery prior to initiation of routine hepatitis C screening have a five-fold increased prevalence of HCV infection compared with the age-matched general population.…”

Section: Pathophysiology Of Liver Dysfunction In Fontan Patientsmentioning

confidence: 99%

Surveillance for liver complications after the Fontan procedure

Hilscher

Johnson

Cetta

et al. 2017

Congenital Heart Disease

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The physiological consequences of the Fontan circulation impose risk for hepatic dysfunction and may culminate in hepatic fibrosis, cirrhosis, and hepatocellular carcinoma. Consensus regarding appropriate surveillance modalities to diagnose liver disease in Fontan patients is lacking, in part due to the relative lack of strong evidence and prospective studies in this patient population. The goal of this paper is to critically review the current evidence and provide recommendations for the surveillance of hepatic complications in the post-Fontan patient population.

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Section: Pathophysiology Of Liver Dysfunction In Fontan Patientsmentioning

confidence: 99%

Surveillance for liver complications after the Fontan procedure

Hilscher

Johnson

Cetta

et al. 2017

Congenital Heart Disease

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“…Studies of patients with CHD who underwent heart surgery before 1992 demonstrate hepatitis C virus exposure in 8.6% of patients and chronic infection in 4% to 5% of patients. 113,114 In cases of frequent transfusion, iron overload can lead to cirrhosis, but this is not a common scenario among patients with CHD. More often, there may be medications used to treat arrhythmias (eg, amiodarone) or pulmonary vascular disease (eg, bosentan) that have hepatotoxic potential.…”

Section: -95mentioning

confidence: 99%

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Lui¹,

Saïdi²,

Bhatt³

et al. 2017

Circulation

Self Cite

175

136

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ABSTRACT:Life expectancy and quality of life for those born with congenital heart disease (CHD) have greatly improved over the past 3 decades. While representing a great advance for these patients, who have been able to move from childhood to successful adult lives in increasing numbers, this development has resulted in an epidemiological shift and a generation of patients who are at risk of developing chronic multisystem disease in adulthood. Noncardiac complications significantly contribute to the morbidity and mortality of adults with CHD. Reduced survival has been documented in patients with CHD with renal dysfunction, restrictive lung disease, anemia, and cirrhosis. Furthermore, as this population ages, atherosclerotic cardiovascular disease and its risk factors are becoming increasingly prevalent. Disorders of psychosocial and cognitive development are key factors affecting the quality of life of these individuals. It is incumbent on physicians who care for patients with CHD to be mindful of the effects that disease of organs other than the heart may have on the well-being of adults with CHD. Further research is needed to understand how these noncardiac complications may affect the long-term outcome in these patients and what modifiable factors can be targeted for preventive intervention.

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“…Several of the physiological derangements inherent in the Fontan circulation predispose to liver damage, including passive venous congestion, low cardiac output, and hypoxia. In addition, the prevalence of hepatitis C infection is greater among patients with CHD who received blood transfusions or underwent cardiac surgery prior to the implementation of high‐sensitivity tests for hepatitis C virus screening in 1992 …”

Section: Features That Distinguish Benign and Malignant Nodules In Pomentioning

confidence: 99%

Congenital Heart Disease and the Liver

Hilscher

Kamath

2019

Clinical Liver Disease

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Outcomes of a Hepatitis C Screening Protocol in At-Risk Adults With Prior Cardiac Surgery

Abstract: Hepatitis C infection in patients with congenital heart disease who underwent surgical palliation prior to 1992 is common, with prevalence higher than the general population. Our data emphasize the continued importance of screening the high-risk adult congenital heart disease patients.

Cited by 14 publications

References 13 publications

Surveillance for liver complications after the Fontan procedure

Surveillance for liver complications after the Fontan procedure

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Congenital Heart Disease and the Liver

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