Outcomes in Diabetic Versus Nondiabetic Patients Who Present With Acute Myocardial Infarction and Are Treated With Drug-Eluting Stents

Syed, Asmir I.; Ben‐Dor, Itsik; Li, Yanlin; Collins, Sara D.; González, Manuel A.; Gaglia, Michael A.; Maluenda, Gabriel; Delhaye, Cédric; Wakabayashi, Kohei; Bonello, Laurant; Labriolle, Axel de; Belle, Loïc; Torguson, Rebecca; Zhang, Xue; Kaneshige, Kimberly; Bernardo, Nelson; Satler, Lowell F.; Kent, Kenneth M.; Suddath, William O.; Pichard, Augusto D.; Lindsay, Joseph; Waksman, Ron

doi:10.1016/j.amjcard.2009.11.010

Cited by 12 publications

(9 citation statements)

References 28 publications

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“…Totally 18 studies [7–11,14–20,25,26,28,29,33,34] and our data reported MI; the pooled analysis showed that DM patients had a higher incidence of MI (RR = 1.31, 95% CI 1.11–1.55, I 2 = 61%) (Fig. 2).…”

Section: Resultsmentioning

confidence: 70%

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Comparison of clinical outcomes after drug-eluting stent implantation in diabetic versus nondiabetic patients in China

et al. 2017

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Diabetes mellitus (DM) has been proved to be a predictor of adverse outcomes after percutaneous coronary intervention (PCI). Drug-eluting stents (DESs) could reduce the adverse events in DM patients. In this study, we aimed to analyze the clinical outcome after DES implantation in diabetic versus nondiabetic patients in China. Totally, 200 Chinese DM patients and 400 Chinese non-DM patients were enrolled in this retrospective study. Compared with non-DM patients, DM patients were more likely to have a higher incidence of cardiac death (3.5% vs. 1.0%, P = .048), stent thrombosis (2.5% vs. 0.5%, P = .044), target lesion revascularization (6.0% vs. 1.8%, P = .005), target vessel failure (15.5% vs. 8.0%, P < .001), target lesion failure (14.0% vs. 4.3%, P < .001), myocardial infarction (4.5% vs. 1.5%, P = .030), and major adverse cardiac events (12.5% vs. 5.0%, P = .001) at 2-year follow-up. However, the incidence of target vessel revascularization (7.5% vs. 5.5%, P = .340) was similar between DB and non-DB patients. Patients with DB (hazard ratio [HR] = 2.54, P = .001), older than 80 years (HR = 1.33, P = .027) with hypercholesterolemia (HR = 1.03, P < .001), serum creatinine >177 μmol/L (HR = 3.04, P = .011), a history of cerebral vascular accident (HR = 4.29, P = .010), or a history of myocardial infarction (HR = 31.4, P < .001) were more likely to experience adverse events. In China, DM could also be served as an independent predictor of adverse outcomes after DES implantation. These patients should be reexamined more frequently.

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Section: Resultsmentioning

confidence: 70%

“…Our result was in accordance with other studies (cardiac death rate varied from 1.1% to 12.4% in DM patients, 0.6% to 4.6% in non-DM patients). [7–9,11,14–20,25,26,28,29,33,34] Syed et al [28] showed a relatively high death rate (DM patients: 12.4%; non-DM patients: 4.6%). This may be attributed to their population characteristics.…”

Section: Discussionmentioning

confidence: 99%

Comparison of clinical outcomes after drug-eluting stent implantation in diabetic versus nondiabetic patients in China

et al. 2017

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“…Syed et al [25] reported that a 1-year composite of death, Q-wave MI, and TLR were not different between AMI patients with and without DM who underwent first-generation DES implantation after adjustment for baseline comorbidities. The cumulative incidence of 2-year MACE was significantly higher in DM patients than non-DM patients in the present study, but DM was not an independent predictor for the event of MACE.…”

Section: Discussionmentioning

confidence: 99%

Comparison of 2-year clinical outcomes between diabetic versus nondiabetic patients with acute myocardial infarction after 1-month stabilization

et al. 2016

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“…Diabetes is an independent risk factor for cardiovascular disease. The vulnerability of myocardial ischemia/reperfusion (I/R) injury in diabetic patients is increased [1,2]. The International Diabetes Federation (IDF) estimates that the total prevalence of diabetes in 2011 is 366 million and is expected to increase to 552 million by 2030 [3].…”

Section: Introductionmentioning

confidence: 99%

Mechanism of N-acetylcysteine in alleviating diabetic myocardial ischemia reperfusion injury by regulating PTEN/Akt pathway through promoting DJ-1

Leng

Xiong

et al. 2020

Bioscience Reports

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Ischemic heart disease is the main cardiovascular complication of diabetes patients which is mainly caused by oxidative stress. DJ-1 is the key regulator for myocardial protection through inhibiting phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and activating Akt (also known as PKB or protein kinase B). This research is to investigate whether the antioxidant N-acetylcysteine (NAC) could alleviate diabetic myocardial ischemia/reperfusion (I/R) injury by the protective molecule DJ-1. DJ-1 in rat myocardial H9c2 cells and cardiac tissue was respectively knocked down by siRNA and adeno-associated virus (AAV). From the present study, it could be found that compared with high glucose (HG)-normal (N)/DM group, hypoxia/reoxygenation (H/R) or I/R injury can aggravate oxidative stress injury and apoptosis rate of myocardial cells, inhibit the expression of Bcl-2, activate the BAX and cleaved caspase-3 (c-caspase-3) protein and PTEN/Akt pathway. However, in the groups of HG-N, DM, HG-N+I/R and DM+I/R, NAC can significantly reduce oxidative stress injury and apoptosis rate of myocytes, promote the Bcl-2 and DJ-1 molecules, inhibit BAX and c-caspase-3 protein and PTEN/Akt pathway. Compared with HG-N+I/R+NAC and DM+I/R+NAC groups, the oxidative stress injury, apoptosis rate of myocardial cells and heart tissues increased after the knockdown of DJ-1, the expression of Bcl-2 and DJ-1 were inhibited, the BAX and c-caspase-3 expression was increased, and PTEN/Akt pathway was activated. Taken together, the findings suggest that NAC can reduce I/R injury in diabetic myocardium by up-regulating the PTEN/Akt pathway through the level of DJ-1.

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Outcomes in Diabetic Versus Nondiabetic Patients Who Present With Acute Myocardial Infarction and Are Treated With Drug-Eluting Stents

Cited by 12 publications

References 28 publications

Comparison of clinical outcomes after drug-eluting stent implantation in diabetic versus nondiabetic patients in China

Comparison of clinical outcomes after drug-eluting stent implantation in diabetic versus nondiabetic patients in China

Comparison of 2-year clinical outcomes between diabetic versus nondiabetic patients with acute myocardial infarction after 1-month stabilization

Mechanism of N-acetylcysteine in alleviating diabetic myocardial ischemia reperfusion injury by regulating PTEN/Akt pathway through promoting DJ-1

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