Outcomes in critically ill chronic lymphocytic leukemia patients

Xhaard, Aliénor; Epelboin, Loïc; Schnell, David; Vincent, François; Lévy, Vincent; Malphettes, Marion; Azoulay, Élie; Darmon, Michaël

doi:10.1007/s00520-013-1744-4

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…The characteristics of the 46 included studies are described in eTable 1 (http://links.lww.com/CCX/B54). Most of the published literature was from Europe ( n = 18) (15–32), followed by Asia ( n = 12) (33–44), North America ( n = 9) (4, 45–52), South America ( n = 5) (5, 53–56), and Oceania ( n = 2) (57, 58). On the other hand, studies from North America contributed the highest number of patients ( n = 37,255), followed by South America ( n = 32,723), Asia ( n = 23,540), Europe ( n = 16,149), and Oceania ( n = 478).…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review and Meta-Analysis Evaluating Geographical Variation in Outcomes of Cancer Patients Treated in ICUs

Nazer

López-Olivo

Brown

et al. 2022

Critical Care Explorations

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Section: Resultsmentioning

confidence: 99%

“…Thirty-seven studies reported data on length of stay in the ICU (4, 5, 16–19, 21, 23–25, 28, 29, 32–36, 38–52, 54–58). The WM length of stay was 5.9 days (95% CI, 5.3–6.5 d), and the median was 5.7 days (range, 2.7–23.7 d).…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review and Meta-Analysis Evaluating Geographical Variation in Outcomes of Cancer Patients Treated in ICUs

Nazer

López-Olivo

Brown

et al. 2022

Critical Care Explorations

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Changes in critically ill cancer patients’ short-term outcome over the last decades: results of systematic review with meta-analysis on individual data

et al. 2019

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Influence of neutropenia on mortality of critically ill cancer patients: results of a meta-analysis on individual data

et al. 2018

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BackgroundThe study objective was to assess the influence of neutropenia on outcome of critically ill cancer patients by meta-analysis of individual data. Secondary objectives were to assess the influence of neutropenia on outcome of critically ill patients in prespecified subgroups (according to underlying tumor, period of admission, need for mechanical ventilation and use of granulocyte colony stimulating factor (G-CSF)).MethodsData sources were PubMed and the Cochrane database. Study selection included articles focusing on critically ill cancer patients published in English and studies in humans from May 2005 to May 2015. For study selection, the study eligibility was assessed by two investigators. Individual data from selected studies were obtained from corresponding authors.ResultsOverall, 114 studies were identified and authors of 30 studies (26.3% of selected studies) agreed to participate in this study. Of the 7515 included patients, three were excluded due to a missing major variable (neutropenia or mortality) leading to analysis of 7512 patients, including 1702 neutropenic patients (22.6%). After adjustment for confounders, and taking study effect into account, neutropenia was independently associated with mortality (OR 1.41; 95% CI 1.23–1.62; P = 0.03). When analyzed separately, neither admission period, underlying malignancy nor need for mechanical ventilation modified the prognostic influence of neutropenia on outcome. However, among patients for whom data on G-CSF administration were available (n = 1949; 25.9%), neutropenia was no longer associated with outcome in patients receiving G-CSF (OR 1.03; 95% CI 0.70–1.51; P = 0.90).ConclusionAmong 7512 critically ill cancer patients included in this systematic review, neutropenia was independently associated with poor outcome despite a meaningful survival. Neutropenia was no longer significantly associated with outcome in patients treated by G-CSF, which may suggest a beneficial effect of G-CSF in neutropenic critically ill cancer patients.Systematic review registrationPROSPERO CRD42015026347. Date of registration: Sept 18 2015Electronic supplementary materialThe online version of this article (10.1186/s13054-018-2076-z) contains supplementary material, which is available to authorized users.

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Outcomes in critically ill chronic lymphocytic leukemia patients

Cited by 4 publications

References 32 publications

A Systematic Review and Meta-Analysis Evaluating Geographical Variation in Outcomes of Cancer Patients Treated in ICUs

A Systematic Review and Meta-Analysis Evaluating Geographical Variation in Outcomes of Cancer Patients Treated in ICUs

Changes in critically ill cancer patients’ short-term outcome over the last decades: results of systematic review with meta-analysis on individual data

Influence of neutropenia on mortality of critically ill cancer patients: results of a meta-analysis on individual data

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