Outcomes in ANCA-associated vasculitis patients with end-stage kidney disease on renal replacement therapy—A meta-analysis

Pope, Victor; Sivashanmugathas, Varunaavee; Moodley, Dirusha; Gunaratnam, Lakshman; Barra, Lillian

doi:10.1016/j.semarthrit.2023.152189

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…Children who required KRT had a higher peak creatinine during their first 3 months after presentation than those who did not require KRT and were more likely to be female and MPO-ANCA positive [37 ▪▪ ]. A 2023 meta-analysis including one pediatric study found that AAV patients with ESKD on KRT had lower relapse risk but higher infection and mortality rates than those without ESKD [38]. Common therapies for renal disease include glucocorticoids, rituximab, cyclophosphamide, and azathioprine.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Update on antineutrophil cytoplasmic autoantibody vasculitis in children

Bloom,

2024

Current Opinion in Rheumatology

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Purpose of review Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is often organ- or life-threatening in children and impacts them during important periods of psychosocial and physical development. This review covers recent advances in the pathophysiology, diagnosis, management, and outcomes of AAV in children and highlights the ongoing need for funding and increased research collaboration. Recent findings Recent work has improved our understanding of AAV disease pathogenesis, potentially identifying new biomarkers and therapeutic targets. Collaborative clinical studies have also highlighted the variable manifestations in children and identified potential factors associated with poorer outcomes. Consensus-based treatment guidelines are also appearing, but clinical trials are still essential to better understanding treatment efficacy and safety in children affected by AAV. New, validated outcome measures, including those that are patient-reported, will facilitate these much-needed clinical trials in pediatric AAV. Summary There is a continued need for more rigorous study in pediatric AAV, however, there is certainly excitement with the increase in recent research relevant to the pediatric population.

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Section: Clinical Manifestationsmentioning

confidence: 99%