Outcomes in 40 cats with discrete intermediate‐ or large‐cell gastrointestinal lymphoma masses treated with surgical mass resection (2005‐2015)

Abstract

Objective To report outcomes in cats with discrete intermediate‐ and large‐cell gastrointestinal (GI) lymphoma masses after surgical resection. Study design Retrospective clinical case series. Animals Forty client‐owned cats in which intermediate‐ or large‐cell GI lymphoma was diagnosed. Methods Records of 40 cats in which discrete intermediate‐ or large‐cell GI lymphoma masses were diagnosed between 2005 and 2015 were reviewed. Cats were included if they survived curative intent surgery and had a known outcome for at least two weeks. Postoperative death was permitted. Data collected included anatomic site, surgical margins, lymphoma subtype, chemotherapy use, and postoperative and long‐term outcome (beyond two weeks). Results Affected sites consisted of small intestines (n = 23), large intestines (n = 9), and stomach (n = 8). Thirty‐six of 40 cats survived to discharge, and 31 cats were alive at suture removal. Median long‐term follow‐up of 22 cats was 111 days (range, 16‐1407). Cats that survived to suture removal had a median survival time (MST) of 185 days (95% confidence interval: 72‐465). Cats with large intestinal masses lived longer than those with small intestinal or gastric masses whether all cats (MST, 675, 64, 96 days, respectively; P = .03) or only those surviving to suture removal were considered. Complete surgical resection (n = 20) was positively associated with survival (370 vs 83 days, P = .016). Conclusion Most cats in this population survived the perioperative period, with MST similar to those reported historically with medical management. Clinical significance Surgical resection may be a reasonable consideration in cats with solitary lymphoma, particularly those with large intestinal masses.

Presumptive precursor-targeted immune-mediated anemia concurrent with gastrointestinal lymphoma in a cat

“…However, we consider that aggressive resection of discrete GI lymphoma well-localized in the stomach may be a reasonable consideration, even if the GI lymphoma is expected as high-grade lymphoma. The two latest studies reported that feline discrete intermediate-or large-cell GI lymphoma with complete surgical margins may survive longer than with incomplete margin or without surgical lymphoma masses resection [4,20]. Probably, complete surgical margins in this case contribute to have good prognosis.…”

Outcome and Prognostic Factors in Cats Undergoing Resection of Intestinal Adenocarcinomas: 58 Cases (2008–2020)

“…Disease progression was considered to have occurred in cats with recurrence of clinical signs whether or not repeat imaging was available. This method of reporting is commonly seen in feline intestinal tumor literature (22)(23)(24), although this method may have overrepresented the number of cats with progressive disease in the current study. The authors elected to not perform a multivariate analysis due to the limited number of cats with complete data sets, which could have resulted in a model with unreliable conclusions and a lack of generalizability.…”

Retrospective assessment of the clinical relevance of surgical biopsies of abdominal lymph nodes in cats: 51 cases (2014–2018)

“…25 Other studies have found no prognostic information on clinical staging of cats with alimentary lymphoma. 26,27 For cats with intestinal MCT and intestinal adenocarcinoma, the absence of LN metastasis is associated with a better prognosis. 28–30…”