Outcomes in 15 Patients with Conjunctival Melanoma Treated with Adjuvant Topical Mitomycin C: Complications and Recurrences

Ditta, Lauren C.; Shildkrot, Yevgeniy; Wilson, Matthew W.

doi:10.1016/j.ophtha.2011.01.060

Cited by 51 publications

(43 citation statements)

References 21 publications

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“…Reported chemotherapeutic agents for CMM include mitomycin C [78–82], and interferon alpha-2b [82–85]. Mitomycin C is the more studied agent, and is currently the preferred adjuvant therapy of most ophthalmologists.…”

Section: Nonexcisional Adjuvant Therapymentioning

confidence: 99%

Management of conjunctival malignant melanoma: a review and update

Wong

Nanji

Karp

2014

Expert Review of Ophthalmology

136

149

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Conjunctival malignant melanoma is a pigmented lesion of the ocular surface. It is an uncommon but potentially devastating tumor that may invade the local tissues of the eye, spread systemically through lymphatic drainage and hematogenous spread, and recur in spite of treatment. Despite its severity, the rarity of available cases has limited the evidence for diagnosis and management. This review will provide an overview of the epidemiology, presentation, diagnosis, management, and surveillance of conjunctival melanoma, with an emphasis on recent advances in biological therapies to treat this disease.

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Section: Nonexcisional Adjuvant Therapymentioning

confidence: 99%

Management of conjunctival malignant melanoma: a review and update

Wong

Nanji

Karp

2014

Expert Review of Ophthalmology

136

149

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“…Although conjunctival melanomas are comparatively rare with an incidence of 0.8/1 000 000,1 2 they are clinically challenging due to their high local recurrence rates3 4 and tendency to metastasise, which in turn is associated with a poor prognosis 5. Currently, there is no specifically targeted therapy for conjunctival melanoma.…”

Section: Introductionmentioning

confidence: 99%

B-Raf inhibition in conjunctival melanoma cell lines with PLX 4720

et al. 2015

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“…Recurrence occurs in more than 50% of the cases with simple surgical excision and increases the risk of metastasis and tumour-related death (Ditta et al 2011).…”

Section: Referencesmentioning

confidence: 99%