Outcomes from ovarian hyperstimulation following the sole administration of gonadotrophin-releasing hormone agonist in the context ofin vitrofertilization: report of two cases and review of the literature

Abstract

The ovarian hyperstimulation after the sole administration of GnRHa is a rare condition. Oocyte retrieval may be a reasonable treatment under these circumstances instead of cycle cancellation. As far as it is known, this is the third case reported of a live birth following the sole administration of GnRHa in the context of IVF.

Progress in understanding human ovarian folliculogenesis and its implications in assisted reproduction

“…In several case reports, women scheduled for COH-IVF presented with multiple follicles development and high E2 levels within or after 2 weeks of GnRH agonist daily administration during the mid or late luteal phase [42][43][44]. It was reported that the retrieval of mature oocytes in luteal phase and embryo were obtained [42][43][44], as well as two pregnancies with the delivery of healthy infants [43,44].…”

“…It was reported that the retrieval of mature oocytes in luteal phase and embryo were obtained [42][43][44], as well as two pregnancies with the delivery of healthy infants [43,44]. The possible explanation could be that recruitable follicles were present in luteal phase despite the presence of a functioning corpus luteum and increased levels of P. These follicles were able to respond to the "flare-up" of FSH produced by the GnRH-a and progress into mature follicles within 14 days [43].…”