“…Some adverse events are rare in the modern era (ie, 1% operative mortality rates [57]) limiting the power to compare outcomes even with the use of large population-based datasets. Retrospective studies comparing VATS and thoracotomy suggest noninferiority of VATS [18,24,58], morbidity [24,25,27,59,60], LOS [18,24,28,59], and costs [18,44]. Randomized trials show no evidence of a difference in morbidity, mortality, or LOS between VATS and open lobectomy [29,30,61].…”