Outcomes following polyetheretherketone (PEEK) cranioplasty: Systematic review and meta-analysis

Punchak, Maria; Chung, Lawrance K.; Lagman, Carlito; Bui, Timothy T.; Lazareff, Jorge A.; Rezzadeh, Kameron; Jarrahy, Reza; Yang, Isaac

doi:10.1016/j.jocn.2017.03.028

Cited by 131 publications

(109 citation statements)

References 34 publications

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“…1 Among the various alloplastic materials that can be used for cranioplasty, PMMA and PEEK have been considered favorable. 1,6,27 A previous systematic review comparing the effects of PEEK with those of autologous bone and titanium mesh revealed no significant difference Heterogeneity: Tau3 = 0.49; Chi2 = 4.97; df = 2 (p = 0.08). I2 = 60%…”

Section: Discussionmentioning

confidence: 99%

“…4,5 Although various materials have been proposed, currently no available material meets these criteria. 1,4 Autologous bone grafts have traditionally been considered the gold standard for cranial reconstruction 6 given that bone is a natural substrate. 7,8 Autologous bone grafts are associated with low cost and low risk and are preferred materials for small-and medium-sized defects.…”

Section: Introductionmentioning

confidence: 99%

“…7,8 Autologous bone grafts are associated with low cost and low risk and are preferred materials for small-and medium-sized defects. 1,6 The disadvantages of autologous bone grafts include the limited quantity of material (as quality depends on the availability of graft donors), difficulty in shaping the graft, and increased morbidity and risk of complications, including infection and bone resorption. 6,9 Alloplast ic materials are alter nat ives to autologous bone grafts; these materials must possess biocompatibility, adequate mechanical resistance, malleability for esthetic purposes, and low risk of infection.…”

Section: Introductionmentioning

confidence: 99%

“…1,6 The disadvantages of autologous bone grafts include the limited quantity of material (as quality depends on the availability of graft donors), difficulty in shaping the graft, and increased morbidity and risk of complications, including infection and bone resorption. 6,9 Alloplast ic materials are alter nat ives to autologous bone grafts; these materials must possess biocompatibility, adequate mechanical resistance, malleability for esthetic purposes, and low risk of infection. Candidate materials include metals (titanium mesh), ceramics (hydroxyapatite and calcium phosphate) and polymers (polymethyl methacrylate [PMMA] or polyetheretherketone [PEEK]).…”

Section: Introductionmentioning

confidence: 99%

“…Titanium mesh generates artifacts in imaging tests and presents difficulty for adaption for soft tissue coverage. 6 Similar to native bone tissue, PMMA offers strength and protection and has long been used in cranioplasty 1,13 owing to its remarkable plasticity and long-term durability. PMMA is easy to shape, lightweight, inexpensive, and produces no visible artifacts in radiographic images.…”

Section: Introductionmentioning

confidence: 99%

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Complications with PMMA compared with other materials used in cranioplasty: a systematic review and meta-analysis

et al. 2018

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Polymethyl methacrylate (PMMA) has been considered a suitable material for cranioplasty. However, no consensus has been reached concerning the best material for cranioplasty with regard to minimizing complications. Thus, this systematic review and meta-analysis aimed to compare the complication rates of PMMA with those of autologous bone and titanium mesh. This review was registered with PROSPERO (CRD42016042725). Systematic searches were conducted on PubMed/ MEDLINE, Scopus, and Web of Science. The focus question was, "Do PMMA prostheses used in cranioplasty have complications rates similar to those of autologous bone and titanium mesh?" A meta-analysis of complication rates was performed on the basis of dichotomous outcomes assessed by risk ratio (RR) with corresponding 95% confidence intervals (CI). From 1014 data sources, 11 articles were selected according to eligibility criteria. These articles involved 1,256 individuals and 1,278 cranioplasties using autologous bone (n = 408), PMMA (n = 379), or titanium (n = 151). The follow-up period ranged from 63 days to 54.3 months. No difference was observed between the complication rates of PMMA and autologous bone (p = 0.94; RR, 0.98; 95%CI, 0.54-1.75) or between PMMA and titanium (p = 0.38; RR, 1.59; 95%CI,. Sub-analysis of the reasons for craniotomy (trauma/non-trauma) was conducted, which revealed no significant difference (p = 0.91; RR, 0.95; 95%CI, 0.37-2.42). The meta-analysis indicated that the use of PMMA yields complication rates that are near those of autologous bone and titanium mesh.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Complications with PMMA compared with other materials used in cranioplasty: a systematic review and meta-analysis

et al. 2018

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Biomedical Device Surface Treatment by Laser‐Driven Hydroxyapatite Penetration‐Synthesis Technique for Gapless PEEK‐to‐Bone Integration

Um,

Lee,

Chae

et al. 2024

Adv Healthcare Materials

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Polyetheretherketone (PEEK), a bioinert polymer known for its mechanical properties similar to bone, is capable of averting stress shielding. Due to these attributes, it finds applications in diverse fields like orthopedics, encompassing cervical disc replacement for the neck and spine, along with dentistry and plastic surgery. However, due to insufficient bonding with bone, various methods such as hydroxyapatite (HA) coating on the surface are attempted. Nonetheless, the interface between the polymer and ceramic, two different materials, tended to delaminate after transplantation, posing challenges in preventing implant escape or dislodgement. This research delves into the laser‐driven hydroxyapatite penetration‐synthesis technique. Differing from conventional coating methods that bond layers of dissimilar materials like HA and PEEK, this technology focuses on synthesizing and infiltrating ionized HA within the PEEK substrate resulting in an interface‐free HA–PEEK surface. Conversely, HA–PEEK with this technology applied achieves complete, gap‐free direct bone–implant integration. Our research involved the analysis of various aspects. By means of these, we quantitatively assesed the enhanced bone bonding characteristics of HA‐PEEK surfaces treated with this approach and offered and explanation for the mechanism responsible for direct bone integration.

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Machine Learning‐Driven Biomaterials Evolution

et al. 2021

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Biomaterials is an exciting and dynamic field, which uses a collection of diverse materials to achieve desired biological responses. While there is constant evolution and innovation in materials with time, biomaterials research has been hampered by the relatively long development period required. In recent years, driven by the need to accelerate materials development, the applications of machine learning in materials science has progressed in leaps and bounds. The combination of machine learning with high‐throughput theoretical predictions and high‐throughput experiments (HTE) has shifted the traditional Edisonian (trial and error) paradigm to a data‐driven paradigm. In this review, each type of biomaterial and their key properties and use cases are systematically discussed, followed by how machine learning can be applied in the development and design process. The discussions are classified according to various types of materials used including polymers, metals, ceramics, and nanomaterials, and implants using additive manufacturing. Last, the current gaps and potential of machine learning to further aid biomaterials discovery and application are also discussed.

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Outcomes following polyetheretherketone (PEEK) cranioplasty: Systematic review and meta-analysis

Cited by 131 publications

References 34 publications

Complications with PMMA compared with other materials used in cranioplasty: a systematic review and meta-analysis

Complications with PMMA compared with other materials used in cranioplasty: a systematic review and meta-analysis

Biomedical Device Surface Treatment by Laser‐Driven Hydroxyapatite Penetration‐Synthesis Technique for Gapless PEEK‐to‐Bone Integration

Machine Learning‐Driven Biomaterials Evolution

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