Outcomes following aortic valve replacement for isolated aortic stenosis with left ventricular dysfunction

Abstract

Outcomes following aortic valve replacement for isolated aortic stenosis with left ventricular dysfunction study was to determine the effects of AVR on left ventricular function and to describe the clinical outcomes in patients with isolated severe AS and LVD. The hypothesis was that AVR in patients with isolated AS and LVD improves LV function. MATERIALS AND METHODS Study populationBetween 2004 and 2013, 1 573 chart records were analysed from the medical database of Inkosi Albert Luthuli Central Hospital, utilising the ICD-9 coding of AVR and AS. These ABSTRACT OUTCOMES FOLLOWING AVR INTRODUCTIONSevere aortic stenosis (AS) is associated with a poor prognosis in patients with left ventricular dysfunction (LVD). Survival is estimated at less than 2 years in patients without aortic valve replacement (AVR).(1,2) A reduced ejection fraction may be related to the severity of the AS and chronic pressure overload of the left ventricle, rather than depressed myocardial contractility (afterload mismatch). Relief of the valvular obstruction, by valve replacement, should allow recovery of left ventricular size and function.(3,4) However, there is a greater surgical risk and morbidity in patients with AS and LVD, which need to be considered. (5,6) Most studies that have described the effects of AVR on ventricular function included patients with coronary artery disease (CAD), which may contribute independently to LVD. Since the presence of CAD is associated with a reduced survival rate following AVR, (2) we aimed to eliminate this variable and evaluate the isolated effect of AVR in those without concomitant CAD. There is no known published data available on survival, changes in ventricular function and long-term follow up from any South African institute to date. The purpose of this

The Association Between Ascending Aortic and Left Ventricular Dimensions in Patients After Aortic Valve Replacement

“…In our study, measurements were only taken one year after surgery. Another study by Naicker et al [ 13 ] demonstrated a significant postoperative increase in LVEF and a non-significant decrease in LVEDD during follow-up echocardiograms performed at an average of 610 ± 123 days after surgery. These findings are consistent with a meta-analysis by Perry and Li, where LVEF was associated with the effect of AVR and vice versa [ 14 ] .…”