Outcomes Associated With Cardiogenic Shock in Takotsubo Syndrome

Vece, Davide Di; Citro, Rodolfo; Cammann, Victoria L.; Kato, Ken; Gili, Sebastiano; Szawan, Konrad A.; Micek, Jozef; Jurisic, Stjepan; Ding, Katharina J.; Bacchi, Beatrice; Schwyzer, Moritz; Candreva, Alessandro; Bossone, Eduardo; D’Ascenzo, Fabrizio; Sarcon, Annahita; Franke, Jennifer; Napp, L. Christian; Jaguszewski, Miłosz; Noutsias, Michel; Münzel, Thomas; Knorr, Maike; Heiner, Susanne; Katus, Hugo A.; Burgdorf, Christof; Schunkert, Heribert; Thiele, Holger; Bauersachs, Johann; Tschöpe, Carsten; Pieske, Burkert; Rajan, Lawrence; Michels, Guido; Pfister, Roman; Cuneo, Alessandro; Jacobshagen, Claudius; Hasenfuβ, Gerd; Karakas, Mahir; Köenig, Wolfgang; Rottbauer, Wolfgang; Said, Samir M.; Braun‐Dullaeus, Ruediger C.; Banning, Adrian P.; Cuculi, Florim; Kobza, Richard; Fischer, Thomas; Vasankari, Tuija; Airaksinen, Juhani; Opolski, Grzegorz; Dworakowski, Rafał; MacCarthy, Philip; Kaiser, Christoph; Oßwald, Stefan; Galiuto, Leonarda; Crea, Filippo; Dichtl, Wolfgang; Empen, Klaus; Felix, Stephan B.; Delmas, Clément; Lairez, Olivier; El‐Battrawy, Ibrahim; Akın, İbrahim; Borggrefe, Martin; Gilyarova, Ekaterina; Shilova, Alexandra; Gilyarov, Mikhail; Horowitz, John D.; Kozel, Martin; Toušek, Petr; Widimský, Petr; Winchester, David E.; Ukena, Christian; Mario, Carlo Di; Prasad, Abhiram; Böhm, Michael; Bax, Jeroen J.; Lüscher, Thomas F.; Ruschitzka, Frank; Ghadri, Jelena R.; Templin, Christian

doi:10.1161/circulationaha.118.036164

Cited by 84 publications

(70 citation statements)

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“…We observed a higher incidence of cardiogenic shock during hospitalization in secondary compared to primary TTS (13.1% vs. 6.1%; P = 0.029). These data are consistent with recent findings from the International Takotsubo Registry showing that physical trigger was a strong predictor of cardiogenic shock at presentation, whereas a negative significant association for emotional trigger was found …”

supporting

confidence: 92%

“…These data are consistent with recent findings from the International Takotsubo Registry showing that physical trigger was a strong predictor of cardiogenic shock at presentation, whereas a negative significant association for emotional trigger was found. 3 Moreover, in our study population, there were no differences in TTS recurrence, allcause or cardiac rehospitalization, and the composite of major adverse cardiac events between primary and secondary forms. However, patients with secondary TTS showed a significantly higher rate of rehospitalization for acute heart failure during follow-up (13.8% vs. 6.1%, P = 0.018).…”

mentioning

confidence: 54%

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Comparison of mortality in primary and secondary Takotsubo cardiomyopathy with severe left ventricular dysfunction: reply

Citro

Silverio

Provenza

et al. 2019

European J of Heart Fail

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supporting

confidence: 92%

mentioning

confidence: 54%

Comparison of mortality in primary and secondary Takotsubo cardiomyopathy with severe left ventricular dysfunction: reply

Citro

Silverio

Provenza

et al. 2019

European J of Heart Fail

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“…Clinical symptoms and signs at presentation, along with electrocardiographic (ECG) and laboratory changes, may mimic acute coronary syndrome (ACS) or acute heart failure . Although TTS has long been considered a benign condition, recent studies reported that it can be associated with significant adverse events both during hospitalization and after discharge . Therefore, there is a compelling need for an optimal preventive therapy to reduce the incidence of adverse events following TTS.…”

Section: Introductionmentioning

confidence: 99%

Impact of aspirin on takotsubo syndrome: a propensity score‐based analysis of the InterTAK Registry

D’Ascenzo

Gili

Bertaina

et al. 2019

European J of Heart Fail

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Aims The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS). Methods and results Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30‐day and 5‐year follow‐up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30‐day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50–3.04, P = 0.64] or 5‐year follow‐up (HR 1.11, 95% CI 0.78–1.58, P = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS‐based methods, i.e. covariate adjustment and inverse probability of treatment weighting. Conclusion In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30‐day and 5‐year follow‐up. These findings should be confirmed in adequately powered randomized controlled trials. http://clinicaltrials.gov Identifier: NCT01947621.

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“…1 As they properly state, the in-hospital course of TTS may be threatened by several complications such as cardiogenic shock, pulmonary oedema and malignant arrhythmias, which have been associated with worse prognosis in both the short and long term. [2][3][4] More specifically, El-Battrawy et al wonder whether the rate of thromboembolic events differs in TTS patients according to the LVEF value at presentation.…”

Section: Predictors Of Thromboembolic Events In Takotsubo Syndrome: Rmentioning

confidence: 99%

“…for their interest in our study focused on the prognostic role of severely reduced left ventricular ejection fraction (LVEF) in Takotsubo syndrome (TTS) . As they properly state, the in‐hospital course of TTS may be threatened by several complications such as cardiogenic shock, pulmonary oedema and malignant arrhythmias, which have been associated with worse prognosis in both the short and long term . More specifically, El‐Battrawy et al .…”

mentioning

confidence: 99%