Outcomes and Recurrence of Initially Resectable Hepatocellular Carcinoma Meeting Milan Criteria: Rationale for Partial Hepatectomy as First Strategy

Tanaka, Shinji; Noguchi, Norio; Ochiai, Takanori; Kudo, Atsushi; Nakamura, Noriaki; Itō, Kōji; Kawamura, T.; Teramoto, Koji; Arii, Shigeki

doi:10.1016/j.jamcollsurg.2006.10.004

Cited by 71 publications

(54 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, hepatic resection is performed as an initial treatment, followed by salvage transplantation when recurrence develops and/or liver function has deteriorated. Correct prediction of the type of recurrence at the initial operation would be useful in the selection of optimal adjuvant therapy 3,9 .…”

Section: Discussionmentioning

confidence: 99%

“…The Editors are satisfied that all authors have contributed significantly to this publication or up to three nodules of maximum diameter 3 cm, without major vascular invasion or distant metastasis) 3 , which have been proposed for selection of patients with HCC for liver transplantation 4 . Even in the event of recurrence after curative resection, patients who meet these criteria have a good prognosis 3 .…”

Section: Introductionmentioning

confidence: 96%

“…Even in the event of recurrence after curative resection, patients who meet these criteria have a good prognosis 3 . In contrast, when the recurrence exceeds the Milan criteria, treatment is limited and the prognosis poor 5 .…”

Section: Introductionmentioning

confidence: 99%

“…The identification of novel biomarkers is required for the accurate prediction of aggressive recurrence at the first diagnosis of recurrent HCC 3 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy

Tanaka

Arii²,

Yasen

et al. 2008

British Journal of Surgery

View full text Add to dashboard Cite

Background: Patterns of cancer recurrence hold the key to prognosis after curative resection. This retrospective study aimed to identify a predictor and therapeutic candidate for aggressive recurrence of hepatocellular carcinoma (HCC).Methods: Primary HCC tissues from 107 patients who had curative resection were analysed. Genome-wide gene expression profiles were investigated using a microarray technique, and clustering analysis was carried out based on the first diagnosis of recurrence according to the Milan criteria. Immunohistochemical expression and array-based comparative genomic hybridization (array-CGH) were also assessed.Results: Microarray analysis revealed overexpression of Aurora kinase B, a chromosome passenger protein kinase, as the most significant predictor of the aggressive recurrence of HCC. Aurora kinase B protein expression was significantly associated with aggressive recurrence (P < 0·001) and prognosis (P < 0·001). Multivariable analysis identified Aurora kinase B as the only independent predictor of aggressive recurrence of HCC (P = 0·031). Array-CGH analysis showed that genomic instability was closely related to Aurora kinase B expression (P = 0·011).Conclusion: Aurora kinase B is an effective predictor of aggressive HCC recurrence, in relation to the genomic instability. It might be worth considering as a molecular target for the adjuvant therapy of HCC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

“…The identification of novel biomarkers is required for the accurate prediction of aggressive recurrence at the first diagnosis of recurrent HCC 3 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy

Tanaka

Arii²,

Yasen

et al. 2008

British Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…In the medium term, diseasefree survival for patients undergoing LR with early stage HCC has been shown to be comparable to that of primary LT. LR also allows for histological analysis of the tumour and those with poor prognostic criteria, such as macroscopic vascular invasion or poor differentiation, should be excluded from LT due to the high likelihood www.wjgnet.com Salvage LT for HCC relies upon the principal that patients that have tumour recurrence following LR are still amenable to LT. Tanaka et al found that 8% of patients who underwent LR within the Milan criteria had tumour recurrence that exceeded Milan criteria [50] . Conversely, only 22% of patients undergoing LR for tumours outside the Milan criteria develop post-resection recurrence that is within Milan criteria [50] . Multivariate analysis identified size of the primary tumour and degree of differentiation as risk factors for recurrence exceeding Milan criteria [50] .…”

Section: Salvage Liver Transplantationmentioning

confidence: 99%

Hepatocellular carcinoma: Defining the place of surgery in an era of organ shortage

Bartlett¹,

Heaton²

2008

WJG

View full text Add to dashboard Cite

Precision medicine based on surgical oncology in the era of genome‐scale analysis and genome editing technology

Tanaka

2018

Annals of Gastroent Surgery

Self Cite

View full text Add to dashboard Cite

Accumulated evidence suggests that multiple molecular and cellular interactions promote cancer evolution in vivo. Surgical oncology is of growing significance to a comprehensive understanding of the malignant diseases for therapeutic application. We have analyzed more than 1000 clinical samples from surgically resected tissue to identify molecular biomarkers and therapeutic targets for advanced malignancies. Cancer stemness and mitotic instability were then determined as the essential predictors of aggressive phenotype with poor prognosis. Recently, whole genome/exome sequencing showed a mutational landscape underlying phenotype heterogeneity in caners. In addition, integrated genomic, epigenomic, transcriptomic, metabolic, proteomic and phenomic analyses elucidated several molecular subtypes that cluster in liver, pancreatic, biliary, esophageal and gastroenterological cancers. Identification of each molecular subtype is expected to realize the precise medicine targeting subtype‐specific molecules; however, there are obstacle limitations to determine matching druggable targets or synthetic lethal interactions. Current breakthroughs in genome editing technology can provide us with unprecedented opportunity to recapitulate subtype‐specific pathophysiology in vitro and in vivo. Given a great potential, on‐demand editing system can design actionable strategy and revolutionize precision cancer medicine based on surgical oncology.

show abstract

Outcomes and Recurrence of Initially Resectable Hepatocellular Carcinoma Meeting Milan Criteria: Rationale for Partial Hepatectomy as First Strategy

Cited by 71 publications

References 19 publications

Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy

Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy

Hepatocellular carcinoma: Defining the place of surgery in an era of organ shortage

Precision medicine based on surgical oncology in the era of genome‐scale analysis and genome editing technology

Contact Info

Product

Resources

About