Outcomes and Complications of Pelvic Chondrosarcomas Treated Using Navigation Guidance and Multidisciplinary Approach: Is the Tumor Volume a Prognostic Factor?

Crimì, Alberto; Binitie, Odion; Crimì, Filippo; Letson, G. Douglas; Joyce, David M.

doi:10.3390/jcm11237111

Cited by 3 publications

(3 citation statements)

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“…In the treatment of forearm STS, it is often difficult to achieve wide margin due to the vicinity of important vascular and nervous structures [ 1 , 4 , 23 ]. To restore the function after resection of the tumor, multidisciplinary team treatment including orthopaedic oncologist, hand surgeon, and plastic surgeon is important [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Results of resection of forearm soft tissue sarcoma

et al. 2023

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Purpose Soft tissue sarcomas (STS) of the forearm are rare. We aim to assess their oncological and functional outcomes. Methods We retrospectively evaluated 34 patients who underwent surgical excision for forearm STS at our institution between 1993 and 2020. We analyzed postoperative Musculoskeletal Tumor Society rating scale (MSTS) and local recurrence-free survival (LRFS), metastasis-free survival, and overall survival (OS) rates. The significance of the following variables was determined: age, sex, histology, tumor size, Fédération Nationale des Centres de Lutte contre le Cancer grade, American Joint Committee on Cancer stage, surgical margin, unplanned excision, metastases upon initial presentation, receipt of chemotherapy, and radiotherapy (RT). Results The postoperative median MSTS score was 28. Bone resection or major nerve palsy was the only factor that influenced MSTS scores. The median MSTS scores in patients with or without bone resection or major nerve palsy were 24 and 29, respectively (P < 0.001). The 5-year LRFS rates was 87%. Univariate analysis revealed that the histological diagnosis of myxofibrosarcoma was the only factor that influenced LRFS (P = 0.047). The 5-year MFS rates was 71%. In univariate analysis, no factors were associated with MFS. The 5-year OS rates was 79%. Age was the only factor that influenced OS (P = 0.01). Conclusion In the treatment of forearm STS, reconstruction of the skin and tendon can compensate for function, while bone resection and major nerve disturbance cannot. Careful follow-up is important, especially in patients with myxofibrosarcoma, due to its likelihood of local recurrence.

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Section: Discussionmentioning

confidence: 99%

Results of resection of forearm soft tissue sarcoma

et al. 2023

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“…De las localizaciones tumorales de nuestra cohorte, 52.9% se encontraban en zona I del ilíaco, dato que coincide con los reportes de la literatura. 19,20,21 En lo que respecta a la toma de biopsias, es importante destacar que en nuestra cohorte se observó una discrepancia entre el grado histopatológico reportado en la biopsia y lo evaluado en el espécimen resecado en 52% de los casos. Este hallazgo es coherente con lo reportado por Laitinen y colegas, 8 donde se concluye que la biopsia diagnóstica no es un método fiable para determinar el grado histológico definitivo ni el potencial de malignidad de este tipo de tumores.…”

Section: Discussionunclassified

“…Esto permitiría contar con evaluaciones objetivas más exactas en comparación con una única medición basada en imágenes. 17,20 Los condrosarcomas son notoriamente resistentes a la quimioterapia y la radioterapia, lo que conlleva una alta morbilidad y mortalidad. Esta realidad subraya la urgencia de desarrollar nuevas opciones de tratamiento.…”

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Márgenes quirúrgicos como factor pronóstico del condrosarcoma de pelvis. Estudio de cohorte en una unidad de sarcomas

Lizcano-Suárez,

Clara-Altamirano,

Velázquez-Rodríguez

et al. 2023

Acta Ortopédica Mexicana

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Artículo originalRESUMEN. Introducción: el condrosarcoma (CS), el segundo tumor maligno óseo primario más común, constituye aproximadamente una cuarta parte de todos los sarcomas óseos primarios. Los márgenes quirúrgicos en el condrosarcoma pélvico tienen un impacto directo como factor pronóstico, tanto en la supervivencia global como en la supervivencia libre de recurrencia de esta enfermedad. Objetivos: analizar el impacto de los márgenes quirúrgicos como factor pronóstico en el condrosarcoma de la pelvis. Material y métodos: cohorte de base de datos retrospectiva con seguimiento prospectivo de sarcomas de pacientes con diagnóstico de condrosarcoma primario de la pelvis que fueron sometidos a tratamiento quirúrgico. Se obtuvieron variables clínico-demográficas, se realizó un análisis descriptivo de cada variable y se contrastaron con las variables desenlace. Resultados: se incluyeron 17 pacientes, de los cuales nueve eran mujeres. La mediana de edad fue de 41 años (rango de 23 a 65 años). El tamaño promedio del tumor fue de 20.9 cm (rango de 5 a 46 cm). El margen quirúrgico promedio fue de 5.3 mm, variando entre 1 y 30 mm, con 58% de márgenes positivos. La supervivencia global promedio fue de 64 meses (rango de 7 a 108 meses). La distribución de la afectación pélvica fue: zona I en nueve pacientes (52.9%), zona II en dos (11.8%), combinación de zonas I-III en dos (11.8%), I+II en uno (5.9%), II+III en uno (5.9%), I-III más sacro en uno (5.9%) y I más sacro en uno (5.9%). Los ABSTRACT. Introduction: chondrosarcoma is the second most common primary malignant tumor, constitutes approximately one quarter of all primary bone sarcomas. Surgical margins in pelvic chondrosarcoma have a direct impact as a prognostic factor, both on overall survival and on recurrence-free survival of this disease. Objectives: to analyze the impact of surgical margins as a prognostic factor in pelvic chondrosarcoma. Material and methods: a retrospective database cohort with prospective followup of sarcomas in patients diagnosed with primary pelvic chondrosarcoma who underwent surgical treatment. Clinical-demographic variables were obtained, a descriptive analysis of each variable was performed, and these were contrasted with the outcome variables. Results: seventeen patients were included, of which nine were female. The median age was 41 years, ranging from 23 to 65 years. The average tumor size was 20.9 cm (range 5 to 46 cm). The average surgical margin was 5.3 mm, ranging from 1 to 30 mm, with 58% positive margins. The average overall survival was 64 months (range 7 to 108 months). The distribution of pelvic involvement was as follows: zone I in nine patients (52.9%), zone II in two (11.8%), a combination of zones I-III in two (11.8%), I+II in one (5.9%), II+III in one (5.9%), I-III plus sacrum in one (5.9%) and I plus sacrum in one (5.9%). Tumor grades were classified as low in seven patients (41.2%), intermediate in sven (41.2%), Márgenes quirúrgicos como factor pronóstico del condrosarcoma de pelvis. Estudio de cohorte en una unidad ...

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