Outcomes and complications of catheter ablation for atrial fibrillation in females

Patel, Dimpi; Mohanty, Prasant; Biase, Luigi Di; Sánchez, Javier; Shaheen, Mazen; Burkhardt, J. David; Bassouni, Mohammed; Cummings, Jennifer E.; Wang, Yan; Lewis, William R.; Díaz, Alcira Ofélia; Horton, Rodney; Beheiry, Salwa; Hongo, Richard; Gallinghouse, G. Joseph; Zagrodzky, Jason; Bailey, Shane; Al‐Ahmad, Amin; Wang, Paul; Schweikert, Robert A.; Natale, Andrea

doi:10.1016/j.hrthm.2009.10.025

Cited by 220 publications

(220 citation statements)

References 19 publications

Supporting

Mentioning

194

Contrasting

Order By: Relevance

“…268,282,283,284,285,286,287,288,289,290,291,292,293,294,295,296,297,298 A recent meta-analysis identified 16 studies involving 5864 individuals reporting on the link between obesity and recurrence of AF after catheter ablation, identifying that there was a 3.1% greater risk of recurrent AF postablation for every one unit increase in BMI (RR 1.03; 95% CI 1.00–1.07). 299 …”

Section: Section 3: Modifiable Risk Factors For Af and Impact On Ablamentioning

confidence: 99%

“…283,289,290,291,316,317,318,319 Although OSA has been associated with poorer outcomes, CPAP appears to attenuate the deleterious impact of OSA. Pooled analysis suggests that although OSA increases the risk of AF recurrence following ablation (RR 1.31; 95% CI 1.16–1.48; P <.001), CPAP therapy improves ablation success to rates comparable with non-OSA populations (RR 1.25; 95% CI 0.77–2.03; P = .37).…”

Section: Section 3: Modifiable Risk Factors For Af and Impact On Ablamentioning

confidence: 99%

“…Clinical history or diagnostic questionnaires (e.g., Berlin questionnaire) formed the basis of OSA diagnosis in some, whereas the diagnosis was rarely excluded by sleep study in non-OSA groups. 283,289,290,291,316 Similarly, treatment efficacy was assessed by self-reported CPAP use. 289,290,291,316 These study deficiencies lead to a poorly defined treatment effect of CPAP on AF recurrence after ablation.…”

Section: Section 3: Modifiable Risk Factors For Af and Impact On Ablamentioning

confidence: 99%

“…Numerous, mostly retrospective, studies have shown that modulation of the renin-angiotensin-aldosterone system does not improve ablation outcome. 289,290,291,333,334 …”

Section: Section 3: Modifiable Risk Factors For Af and Impact On Ablamentioning

confidence: 99%

“…A large, retrospective multicenter study involved 3265 consecutive patients with drug-refractory AF who underwent PVI. 289,290,291 Women constituted a much lower percentage of the patients referred for ablation, were referred later for ablation, had failed more AADs, more often had hypertension, and were older at the time of the procedure. After 24 ± 16 months of follow-up, the women had significantly lower success rates than the men, defined as single-procedure freedom from recurrent AF off AADs (68.5 vs 77.5%; P <.001).…”

Section: Outcomes Of Af Ablation In Populations Not Well Represented mentioning

confidence: 99%

See 4 more Smart Citations

2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design

Calkins,

Kuck,

Cappato

et al. 2012

Heart Rhythm

Self Cite

1,762

1,468

View full text Add to dashboard Cite

Section: Section 3: Modifiable Risk Factors For Af and Impact On Ablamentioning

confidence: 99%

Section: Section 3: Modifiable Risk Factors For Af and Impact On Ablamentioning

confidence: 99%

Section: Section 3: Modifiable Risk Factors For Af and Impact On Ablamentioning

confidence: 99%

“…Numerous, mostly retrospective, studies have shown that modulation of the renin-angiotensin-aldosterone system does not improve ablation outcome. 289,290,291,333,334 …”

Section: Section 3: Modifiable Risk Factors For Af and Impact On Ablamentioning

confidence: 99%

Section: Outcomes Of Af Ablation In Populations Not Well Represented mentioning

confidence: 99%

See 3 more Smart Citations

2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design

Calkins,

Kuck,

Cappato

et al. 2012

Heart Rhythm

Self Cite

1,762

1,468

View full text Add to dashboard Cite

Sex and Catheter Ablation for Ventricular Tachycardia

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

Clinical Outcomes by Sex After Pulsed Field Ablation of Atrial Fibrillation

Turagam,

Neuzil,

Schmidt

et al. 2023

JAMA Cardiol

View full text Add to dashboard Cite

ImportancePrevious studies evaluating the association of patient sex with clinical outcomes using conventional thermal ablative modalities for atrial fibrillation (AF) such as radiofrequency or cryoablation are controversial due to mixed results. Pulsed field ablation (PFA) is a novel AF ablation energy modality that has demonstrated preferential myocardial tissue ablation with a unique safety profile.ObjectiveTo compare sex differences in patients undergoing PFA for AF in the Multinational Survey on the Methods, Efficacy, and Safety on the Postapproval Clinical Use of Pulsed Field Ablation (MANIFEST-PF) registry.Design, Setting, and ParticipantsThis was a retrospective cohort study of MANIFEST-PF registry data, which included consecutive patients undergoing postregulatory approval treatment with PFA to treat AF between March 2021 and May 2022 with a median follow-up of 1 year. MANIFEST-PF is a multinational, retrospectively analyzed, prospectively enrolled patient-level registry including 24 European centers. The study included all consecutive registry patients (age ≥18 years) who underwent first-ever PFA for paroxysmal or persistent AF.ExposurePFA was performed on patients with AF. All patients underwent pulmonary vein isolation and additional ablation, which was performed at the discretion of the operator.Main Outcomes and MeasuresThe primary effectiveness outcome was freedom from clinically documented atrial arrhythmia for 30 seconds or longer after a 3-month blanking period. The primary safety outcome was the composite of acute (&lt;7 days postprocedure) and chronic (&gt;7 days) major adverse events (MAEs).ResultsOf 1568 patients (mean [SD] age, 64.5 [11.5] years; 1015 male [64.7%]) with AF who underwent PFA, female patients, as compared with male patients, were older (mean [SD] age, 68 [10] years vs 62 [12] years; P &lt; .001), had more paroxysmal AF (70.2% [388 of 553] vs 62.4% [633 of 1015]; P = .002) but had fewer comorbidities such as coronary disease (9% [38 of 553] vs 15.9% [129 of 1015]; P &lt; .001), heart failure (10.5% [58 of 553] vs 16.6% [168 of 1015]; P = .001), and sleep apnea (4.7% [18 of 553] vs 11.7% [84 of 1015]; P &lt; .001). Pulmonary vein isolation was performed in 99.8% of female (552 of 553) and 98.9% of male (1004 of 1015; P = .90) patients. Additional ablation was performed in 22.4% of female (124 of 553) and 23.1% of male (235 of 1015; P = .79) patients. The 1-year Kaplan-Meier estimate for freedom from atrial arrhythmia was similar in male and female patients (79.0%; 95% CI, 76.3%-81.5% vs 76.3%; 95% CI, 72.5%-79.8%; P = .28). There was also no significant difference in acute major AEs between groups (male, 1.5% [16 of 1015] vs female, 2.5% [14 of 553]; P = .19).Conclusion and RelevanceResults of this cohort study suggest that after PFA for AF, there were no significant sex differences in clinical effectiveness or safety events.

show abstract

Outcomes and complications of catheter ablation for atrial fibrillation in females

Cited by 220 publications

References 19 publications

2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design

2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design

Sex and Catheter Ablation for Ventricular Tachycardia

Clinical Outcomes by Sex After Pulsed Field Ablation of Atrial Fibrillation

Contact Info

Product

Resources

About