Outcomes after intestinal transplantation: a single-center experience over a decade

Farmer, Douglas G.; McDiarmid, Sue V.; Yersiz, Hasan; Cortina, Galen; Vargas, Jorge; Maxfield, Anne; Vandenbogaart, B.; Corrêa, Maria Clara Medina; Kroeber, Alexander; Geevarghese, Sunil K.; Busuttil, Ronald W.

doi:10.1016/s0041-1345(02)02657-x

Cited by 19 publications

(12 citation statements)

References 5 publications

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“…Frequent central line-related sepsis (two episodes of systemic sepsis secondary to line infection per year, one episode of line-related fungemia, septic shock, or acute respiratory distress syndrome) 4. Frequent severe dehydration [66,110,[112][113][114][115] Posttransplant complications Complications of intestinal transplantation are multiple and frequent and can be complex and life-threatening.…”

Section: Indications For Transplantationmentioning

confidence: 99%

“…Other reported surgical-related events include intestinal perforation, wound dehiscence with evisceration, intra-abdominal abscess, and chylous ascites. Morbidity and mortality from the surgical procedure itself and the anesthesia should always be kept in mind [110,[115][116].…”

Section: Surgical Complicationsmentioning

confidence: 99%

“…Postoperative hemorrhage may be due to coagulopathy or portal hypertension from preexisting liver failure in patients requiring a combined small bowel-liver transplant, from vascularized adhesions due to previous surgeries or technical problems originating from anastomotic leaks, or from bleeding from the peritoneal surfaces. In the setting of normal coagulation, timely surgical re-exploration and repair are necessary [110,[115][116][117][118][119].…”

Section: Surgical Complicationsmentioning

confidence: 99%

“…Surgical re-exploration is required for repair of dehiscence or revision of the anastomosis. Biliary obstruction is a later complication and is usually secondary to the development of a biliary stricture [110,[115][116][117][118][119].…”

Section: Surgical Complicationsmentioning

confidence: 99%

“…Thrombosis of the major arteries results in necrosis of the tissue nourished by that arterial supply which may require graft removal. Venous outflow obstruction may occur in patients receiving an isolated small bowel transplant secondary to obstruction or thrombosis of the anastomosis of the superior mesenteric vein and portal vein axis [110,[115][116][117][118][119].…”

Section: Surgical Complicationsmentioning

confidence: 99%

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Short Bowel Syndrome: Parenteral Nutrition Versus Intestinal Transplantation. Where Are We Today?

et al. 2007

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Current management of short bowel syndrome (SBS) revolves around the use of home TPN (HPN). Complications include liver disease, catheter-related infections or occlusions, venous thrombosis, and bone disease. Patient survival with SBS on TPN is 86% and 75% at 2 and 5 years, respectively. Surgical management of SBS includes nontransplant surgeries such as serial transverse enteroplasty and reanastomosis. Small bowel transplant has become increasingly popular for management of SBS and is usually indicated when TPN cannot be continued. Posttransplant complications include graft-versus-host reaction, infections in an immunocompromised patient, vascular and biliary diseases, and recurrence of the original disease. Following intestinal-only transplants, patient and graft survival rate is 77% and 66% after 1 year. After 5 years the survival figures are 49% and 34%, respectively. Future improvements in survival and quality of life will enhance small bowel transplant as a viable treatment option for patients with SBS.

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