Outcomes After Hepatic and Pulmonary Metastasectomies Compared With Pulmonary Metastasectomy Alone in Patients With Colorectal Cancer Metastasis to Liver and Lungs

Hattori, Norifumi; Kanemitsu, Yukihide; Kono, Koji; Shimizu, Yasuhiro; Sano, Tsuyoshi; Senda, Yoshiki; Mitsudomi, Tetsuya; Fukui, Takayuki

doi:10.1007/s00268-013-1954-4

Cited by 32 publications

(31 citation statements)

References 56 publications

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“…Therefore, carefully selected patients with synchronous metastases confined to the lung and liver can be candidates for radical surgery. Previous studies projected a 5-year survival of 25-74% following liver and lung resections for metastases from CRC in selected patients (17,(20)(21)(22)(23), which were similar to the surgical outcomes for CRC with liver-only or lung-only metastases. Consistent with previous findings (18,19), patients who underwent curative resections achieved a markedly longer OS than those who underwent palliative therapies in the present study (Fig.…”

Section: Discussionmentioning

confidence: 57%

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Predictors and outcome of complete removal of colorectal cancer with synchronous lung metastases

Nozawa

Tanaka

Nishikawa

et al. 2015

Molecular and Clinical Oncology

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Abstract. The prognosis-improving effect of radical surgery has been demonstrated in patients with colorectal cancer (CRC) with liver metastases. However, few studies have examined the effectiveness of treatments for CRC with metastases in organs other than the liver. The aim of the present study was to evaluate the outcome of surgical treatment for CRC with lung metastases. The study retrospectively examined 57 primary CRC patients (28 men, median age of 65 years) with synchronous lung metastases who underwent surgery between 2003 and 2012. Data such as clinicopathological parameters, metastasized organs, and the details of surgery, recurrence and survival periods were extracted and analyzed. Curative resection was performed in 10 patients ('curative group'). Primary tumors were resected without metastasectomy in 37 patients ('non-curative group'), whereas 10 underwent stoma surgery ('stoma group'). All the metastasized lesions were confined to the lung and liver in the curative group. By contrast, 43% of the non-curative/stoma groups had metastases in organs other than the lung and liver. Multivariate analyses indicated the absence of extrahepatic metastases as the only predictor of curative resection in CRC patients with lung metastases. The 3-year overall survival rates for the curative, non-curative and stoma groups were estimated as 74, 20 and 17%, respectively (P=0.0007). In conclusion, curative resection was possible in CRC patients with lung metastases if other disseminated lesions were limited to the liver and this treatment resulted in a longer survival time. Furthermore, palliative resection may contribute to a better prognosis compared to stoma surgery alone in selected cases.

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Section: Discussionmentioning

confidence: 57%

“…The 3-year survival rate after pulmonary metastasectomy ranged from 53 to 80% and the 5-year survival rate was reported to be 37-68% (12)(13)(14)(15)(16)(17). However, subjects in these studies had synchronous and metachronous lung metastases (12,13,15).…”

Section: Discussionmentioning

confidence: 93%

Predictors and outcome of complete removal of colorectal cancer with synchronous lung metastases

Nozawa

Tanaka

Nishikawa

et al. 2015

Molecular and Clinical Oncology

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“…In a retrospective study, Hattori et al evaluated outcomes after pulmonary resection of colorectal metastases in patients with or without a curative hepatic metastasectomy. The 5-year OS of the lung metastasectomy group was significantly better than that of the liver and lung metastasectomy group 6. Similarly, a Japanese study showed that surgical resection offers a chance to prolong survival in colorectal cancer patients with resectable pulmonary metastases 7…”

Section: Discussionmentioning

confidence: 96%

Role of metastasectomy and chemotherapy in carcinoma of uterine cervix

Nasir

Mansha²,

Abbası

et al. 2017

BMJ Case Reports

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Squamous cell carcinoma of uterine cervix is potentially a curable disease; however, many patients treated with definitive chemoradiotherapy develop distant metastases, with few of them having a single metastatic deposit. There are no guidelines for the treatment of patients with oligometastatic cervical cancer.We present a case of a patient with International Federation of Gynecology and Obstetrics (FIGO) Stage IIB squamous cell carcinoma of uterine cervix. She was successfully treated with concurrent chemoradiotherapy with definitive intent. One year later, she developed a solitary pulmonary nodule for which she underwent resection followed by chemotherapy. She is free of any local or distant disease at 5 years of regular follow-up.

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“…Полное циторедуктивное хирургическое лечение -единственный метод, дающий пациентам шанс на долгосрочную выживаемость. Доля таких больных в нашей работе невелика, а актуариальная 3-летняя ОВ составляет 60 % по сравнению с 37-68 % по данным зарубежных публикаций [15,[18][19][20][21][22].…”

Section: Discussionunclassified

Colorectal cancer with synchronous lung metastases: clinical characteristics, treatment, prognosis

Расулов¹,

Давыдов²,

Алиев³

et al. 2016

Onkol. koloproktol.

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Outcomes After Hepatic and Pulmonary Metastasectomies Compared With Pulmonary Metastasectomy Alone in Patients With Colorectal Cancer Metastasis to Liver and Lungs

Cited by 32 publications

References 56 publications

Predictors and outcome of complete removal of colorectal cancer with synchronous lung metastases

Predictors and outcome of complete removal of colorectal cancer with synchronous lung metastases

Role of metastasectomy and chemotherapy in carcinoma of uterine cervix

Colorectal cancer with synchronous lung metastases: clinical characteristics, treatment, prognosis

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