Outcomes after conservative treatment of advanced-stage serous borderline tumors of the ovary

Uzan, Catherine; Kane, A.; Rey, Annie; Gouy, S.; Duvillard, P.; Morice, Philippe

doi:10.1093/annonc/mdp267

Cited by 107 publications

(90 citation statements)

References 28 publications

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“…The studies included 2624 patients with serous borderline ovarian tumour (sBOT), 2120 patients with mucinous borderline ovarian tumour (mBOT) 165 other types of BOT (endometrioid, mixed, clear cell tumours and unspecified subtypes, ( Table 2). Of these studies, seven included only patients with sBOT [1,7,10,11] (four of which included only late-stage sBOT [12][13][14][15]), and two included only mBOT [16,17]. Regarding the presence of implants, 18 studies mentioned the presence and type of implants, while three mentioned only the presence of implants.…”

Section: Participant Characteristicsmentioning

confidence: 99%

“…Considering the studies that included only sBOT patients and those studies where recurrence data were provided according to histological subtypes, a total of 433 sBOT patients, enclosing 10 studies [3,[11][12][13][14][15][21][22][23][24], were analysed. The recurrence rate for C, USO and USO + CC were respectively 43.2% (95% CI = 0.349-0.519), 32.1% (95% CI = 0.251-0.400) and 15.3% (95% CI = 0.064-0.320).…”

Section: Sub-analysis For Sbotmentioning

confidence: 99%

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Conservative surgery in ovarian borderline tumours: A meta-analysis with emphasis on recurrence risk

Vasconcelos

Mendes

2015

European Journal of Cancer

112

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Section: Participant Characteristicsmentioning

confidence: 99%

Section: Sub-analysis For Sbotmentioning

confidence: 99%

Conservative surgery in ovarian borderline tumours: A meta-analysis with emphasis on recurrence risk

Vasconcelos

Mendes

2015

European Journal of Cancer

112

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“…Data from the recent literature are reassuring regarding the efficacy and safety of conservative surgery (i.e., involving the preservation of the uterus and at least part of one ovary, with comprehensive surgical staging) for borderline tumors of the ovary in all stages [68,70,110]. When conservative management is not feasible because of massive bilateral ovarian tumor involvement, at least the uterus can be preserved for eventual transfer of frozen embryos obtained before radical surgery.…”

Section: Conservative Surgerymentioning

confidence: 99%

Diagnosis, Treatment, and Follow-Up of Borderline Ovarian Tumors

et al. 2012

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After completing this course, the reader will be able to:1. Compare the epidemiologic and reproductive risk factors in BOTs with those in ovarian cancers and describe the molecular background of development of BOTs.2. Use the pathological terminology with either original grouping of borderline category or new subclassification of BOTs and assess the major predictor of recurrence and survival.3. Determine an appropriate diagnostic algorithm for patients with symptoms suggesting malignant ovarian tumors that will identify borderline ovarian tumors when present.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME ABSTRACTBorderline ovarian tumors represent a heterogeneous group of noninvasive tumors of uncertain malignant potential with characteristic histology. They occur in younger women, are present at an early stage, and have a favorable prognosis, but symptomatic recurrence and death may be found as long as 20 years after therapy in some patients. The molecular changes in borderline ovarian tumors indicate linkage of this disease to type I ovarian tumors (lowgrade ovarian carcinomas). The pathological stage of disease and subclassification of extraovarian disease into invasive and noninvasive implants, together with the presence of postoperative macroscopic residual disease, appear to be the major predictor of recurrence and survival. However, it should be emphasized that the most important negative prognostic factor for recurrence is just the use of conservative surgery, but without any impact on patient survival because most recurrent diseases are of the borderline type-easily curable and with an excellent prognosis. Borderline tumors are difficult masses to correctly preoperatively diagnose using imaging methods because their macroscopic features may overlap with invasive and benign ovarian tumors. Over the past several decades, surgical therapy has shifted from a radical approach to more conservative treatment; however, oncologic safety must always be balanced. Follow-up is essential using routine ultrasound imaging, with special attention paid to the remaining ovary in conservatively treated patients. Current literature on this topic leads to a number of controversies that will be discussed thoroughly in this article, with the aim to provide recommendations for the clinical management of these patients. The Oncologist

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“…Uzan found that histological items, such as type of pathology (serous or mucinous), papillary projection, and micro invasion, were not associated with recurrence rate of BOT (16). However, in another study, it was shown that the mucinous type caused higher recurrence rate and shorter interval between diagnosis and relapse (17).…”

Section: Discussionmentioning

confidence: 96%

Recurrence and Fertility Rate in Females with Borderline Ovarian Tumor

Mousavi

Shooshtari

Nassiri

et al. 2017

J Obstet Gynecol Cancer Res

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Background: Currently, the prevalence of borderline ovarian tumors is increasing, and given the higher diagnosis in the third and fourth decades of life, fertility sparing procedures are widely used. There are important consequences in females with borderline ovarian tumors and number of effective factors on recurrence and fertility rate. Methods: In this cohort study, the required information was collected from a file of 43 patients with final pathologic diagnosis of borderline ovarian tumor, who had undertaken fertility sparing surgery at Imam Khomeini Hospital, Tehran University of medical science, and recurrence rate, fertility rate, and the effect of different variables were studied. Results: There were significant correlations between OCP consumption, serous pathology, micro invasion in pathology, advanced stages, and recurrence rate of BOT, while this relationship was not found between parity, surgical methods (laparotomy and laparoscopy), surgical techniques (cystectomy and USO), papillary projection, and recurrence rate. Conclusions: Although the recurrence rate was higher in the current research when compared to other previous studies, yet only in one patient, the pattern of recurrence was invasive epithelial carcinoma, thus in the current study the overall survival did not seem to change. The results of this study on fertility rate are comparable to other studies on this issue. Therefore, these methods are recommended for young patients and emphasis should be place on follow-up.

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Outcomes after conservative treatment of advanced-stage serous borderline tumors of the ovary

Cited by 107 publications

References 28 publications

Conservative surgery in ovarian borderline tumours: A meta-analysis with emphasis on recurrence risk

Conservative surgery in ovarian borderline tumours: A meta-analysis with emphasis on recurrence risk

Diagnosis, Treatment, and Follow-Up of Borderline Ovarian Tumors

Recurrence and Fertility Rate in Females with Borderline Ovarian Tumor

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