Outcomes after Cholecystectomy in Patients with Sickle Cell Disease: Does Acuity of Presentation Play a Role?

Ramdath, Asa; Zeineddin, Ahmad; Nizam, Wasay; Kearse, LaDonna; Olufajo, Olubode A.; Williams, Mallory

doi:10.1016/j.jamcollsurg.2020.02.046

Cited by 9 publications

(10 citation statements)

References 14 publications

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“…For example, CBD obstruction has been reported among near half of the symptomatic children and young adults with SCD, which is higher than the rates reported among the general population who underwent cholecystectomy (10–15%) 10,12,13 . A previous analysis of 149 415 patients with gallbladder diseases from the United States showed that SCD patients had higher complication rates and longer lengths of stay than the general population and these differences are pronounced among those who underwent surgery in the acute setting 14 …”

Section: Introductionmentioning

confidence: 97%

“…While most of these gallbladder stones are asymptomatic, some of them can result in infection and inflammation of the gallbladder, along with other surgical complications in the biliary tract 8,9 . Cholelithiasis can lead to cholecystitis acute and chronic cholecystitis, cholangitis, common bile duct (CBD) obstruction, and gallstone pancreatitis 12–14 …”

Section: Introductionmentioning

confidence: 99%

“… 8 , 9 Cholelithiasis can lead to cholecystitis acute and chronic cholecystitis, cholangitis, common bile duct (CBD) obstruction, and gallstone pancreatitis. 12 , 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

“… 10 , 12 , 13 A previous analysis of 149 415 patients with gallbladder diseases from the United States showed that SCD patients had higher complication rates and longer lengths of stay than the general population and these differences are pronounced among those who underwent surgery in the acute setting. 14 …”

Section: Introductionmentioning

confidence: 99%

“…The preponderance of cholelithiasis in SCD has made cholecystectomy the most commonly performed surgical procedure in SCD patients, comprising up to 40% of the surgical procedures. 11 , 12 , 13 , 14 , 15 Moreover, prophylactic cholecystectomy has been widely described and considered for SCD patients with asymptomatic cholelithiasis because of several reasons such as the noted higher prevalence of cholelithiasis in SCD patients and the similarity between clinical symptoms of biliary complications and vaso‐occlusive crisis (i.e. acute abdominal pain, jaundice, fever, and leukocytosis), which may render definitive diagnosis and management difficulty.…”

Section: Introductionmentioning

confidence: 99%

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Correlates of gallbladder stones among patients with sickle cell disease: A meta‐analysis

et al. 2021

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Sickle cell disorders are the most common hemoglobinopathies worldwide. Clinical variability of sickle cell disease (SCD) and susceptibility to its complications have been attributed to hematologic, genetic, and other influencing factors. This review aimed to provide further summary and analyses of the prevalence and factors associated with cholelithiasis among patients with SCD. A systematic database search was conducted in MEDLINE (PubMed), ScienceDirect, Google Scholar, World Health Organization Virtual Health Library, Cochrane Library databases, and System for Information on Gray Literature in Europe (SIGLE). Pooled prevalence, odds ratio (OR), and standardized mean difference (SMD) with the corresponding 95% confidence interval (CI) were calculated using Comprehensive Meta‐Analysis Software version 3.3. A total of 34 studies that fulfilled the eligibility criteria were included in the analyses. The overall prevalence of cholelithiasis among SCD patients was 25.3% (95% CI 19.4–32.3%). The risk of developing cholelithiasis was significantly associated with lower total hemoglobin level (SMD = −0.45; P = 0.002), lower hemoglobin F (HbF) level (SMD = −0.85; P = 0.003), higher total serum bilirubin level (SMD = 1.15; P < 0.001), higher reticulocytes count (SMD = 0.44; P = 0.007), and UDP‐glucuronosyltransferase‐1A1 enzyme (UGT1A1) promoter polymorphism. This review provides a comprehensive view of the high rate of cholelithiasis and its associated factors in SCD patients.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

“… 8 , 9 Cholelithiasis can lead to cholecystitis acute and chronic cholecystitis, cholangitis, common bile duct (CBD) obstruction, and gallstone pancreatitis. 12 , 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correlates of gallbladder stones among patients with sickle cell disease: A meta‐analysis

et al. 2021

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Age‐ and sex‐specific rates of gall bladder disease in children with sickle cell disease

Agawu

Shults

Smith‐Whitley

et al. 2022

Pediatric Blood & Cancer

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Background Children with sickle cell disease (SCD) have an increased risk for gallstones due to chronic hyperbilirubinemia from hemolysis. Although gallstones are a known complication, there is variability in estimates of disease burden and uncertainty in the association between sex and gall bladder disease (GBD). Methods This was a retrospective cohort study of children with SCD using administrative claims data (January 1, 2014–December 31, 2018). Population‐averaged multivariable panel‐data logistic regression models were used to evaluate the association between GBD clinical encounters (outcome) and two exposures (age and sex). Annual GBD risk was calculated using predictive margins, adjusting for disease severity, transfusion frequency, and hydroxyurea exposure. Results A total of 13,745 individuals (of 21,487 possible) met inclusion criteria. The population was evenly split across sex (49.5% female) with predominantly Medicaid insurance (69%). A total of 946 individuals (6.9%) had GBD, 432 (3.1%) had a gallstone complication, and 487 (3.5%) underwent cholecystectomy. The annual risk of GBD rose nonlinearly from 1 to 5% between ages 1 and 19 years with no difference between males and females. Cholecystectomy occurred primarily in individuals with GBD (87%), and neither age nor sex was associated with cholecystectomy in this population. High disease severity (compared with low) more than doubled the annual risk of GBD at all ages. Conclusions GBD is associated with age but not sex in children with SCD. Neither age nor sex is associated with risk of cholecystectomy. High disease severity increases the rate of GBD at all ages.

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Medical and Non-medical Costs of Sickle Cell Disease and Treatments from a US Perspective: A Systematic Review and Landscape Analysis

Baldwin

Jiao

Basu

et al. 2022

PharmacoEconomics Open

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Background Sickle cell disease (SCD) is a complex genetic disorder that manifests in infancy and progresses throughout life in the form of acute and chronic complications. As the upfront costs of potentially curative, genetic therapies will likely be high, an assessment and comprehensive characterization of the medical and non-medical cost burden will inform future decision making. Objective We sought to systematically summarize the existing literature surrounding SCD medical and non-medical costs. Methods We searched MEDLINE and EMBASE (2008-2020) and identified US-based studies that detailed medical or non-medical costs. Eligible studies provided empirical estimates about any aspect of cost or SCD individuals of all ages and their caregivers. Study quality was assessed using the Newcastle-Ottawa Scale, and costs were adjusted to 2019 US$. Results Search queries returned 479 studies, with 342 from medical burden searches and 137 from non-medical burden searches, respectively. Herein, we report the results of the 40 studies that contained relevant cost information: 39 detailed medical costs and 1 detailed non-medical costs. Costs were higher for SCD patients when compared with non-SCD individuals

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Outcomes after Cholecystectomy in Patients with Sickle Cell Disease: Does Acuity of Presentation Play a Role?

Cited by 9 publications

References 14 publications

Correlates of gallbladder stones among patients with sickle cell disease: A meta‐analysis

Correlates of gallbladder stones among patients with sickle cell disease: A meta‐analysis

Age‐ and sex‐specific rates of gall bladder disease in children with sickle cell disease

Medical and Non-medical Costs of Sickle Cell Disease and Treatments from a US Perspective: A Systematic Review and Landscape Analysis

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