Outcome predictors of platelet‐rich plasma injection for moderate carpal tunnel syndrome

Shen, Yu-Ping; Li, Tsung-Ying; Chou, Yu‐Ching; Wu, Yung-Tsan

doi:10.1111/ijcp.14482

Cited by 6 publications

(5 citation statements)

References 52 publications

(75 reference statements)

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“…Several predictive factors that might influence the clinical efficacy of PRP treatment including age and different PRP concentration have been reported. However, it remains controversial depending on different disease nature ( Gentile and Garcovich, 2020 ; Alessio-Mazzola et al, 2021 ; Shen et al, 2021 ). In 60 cases of symptomatic knee osteoarthritis receiving homologous intra-articular PRP injections, a less favorable clinical outcome was reported in patients aged ≥ 80 years versus those age 65–79 years ( Bottegoni et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

The Efficacy and Mid-term Durability of Urethral Sphincter Injections of Platelet-Rich Plasma in Treatment of Female Stress Urinary Incontinence

Chiang

Kuo

2022

Front. Pharmacol.

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Aims: This study investigated the therapeutic effect of repeated urethral sphincter injections of autologous platelet-rich plasma (PRP) in treatment of stress urinary incontinence (SUI) in women due to intrinsic sphincter deficiency (ISD) refractory to medical treatment or after the first anti-incontinence surgery.Methods: Twenty-six women with SUI due to urodynamically proven ISD were prospectively enrolled. Five milliliters of PRP (2.5–5 times of the platelet concentrations in peripheral blood) were injected into the external sphincter at 5 sites, with 4 treatments at monthly interval. The primary end-point was post-treatment Global Response Assessment (GRA, scored 0–3) score after four PRP treatments. A GRA ≥ 2 was considered as a successful result. The secondary endpoints included changes in visual analog scale (VAS) of SUI and urodynamic parameters. The follow-up date was 12 months after the fourth PRP treatment.Results: The mean age was 61.7 ± 15.3 years. The overall success rate was 50% with the post-treatment mean GRA of 1.5 ± 1.1. Complete dryness was achieved in 12 patients (46.2%) after the PRP treatment, and 7 (26.9%) kept total continence at 12 months. The mean VAS of SUI score decreased significantly from 6.4 ± 2.3 to 3.9 ± 2.3 after treatment (p < 0.001). The abdominal leak point pressure increased significantly from 117.5 ± 63.8 to 133.6 ± 61.7 cmH2O (p = 0.045). No perioperative adverse events or severe complications occurred, except 1 (3.8%) patient reported straining to void which was self-limited.Conclusion: Repeated urethral sphincter injections of autologous PRP are a safe procedure that provides significant reduction in the severity of female SUI and a mid-term durability, suggesting PRP treatment is effective to increase urethral sphincter resistance for female SUI.

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Section: Discussionmentioning

confidence: 99%

The Efficacy and Mid-term Durability of Urethral Sphincter Injections of Platelet-Rich Plasma in Treatment of Female Stress Urinary Incontinence

Chiang

Kuo

2022

Front. Pharmacol.

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“…Due to its novelty, there is also little evidence on factors associated with failure of USTD. 14 , 15 …”

Section: Discussionmentioning

confidence: 99%

“…Postprocedure physical therapy has been positively associated with USTD outcomes for LET, and body mass index, bodyweight, and severity have been found to be risk factors for PRP outcomes for other conditions. 12 , 14 , 15 There is a need for information on additional risk factors specific to outcomes in LET to assist in patient and physician decision making regarding the condition. The purpose of this study was to assess the efficacy of PRP and USTD while also studying patient characteristics as risk factors for treatment failure.…”

mentioning

confidence: 99%

Efficacy of Ultrasonic Tenotomy and Debridement and Platelet-Rich Plasma Injections for Lateral Elbow Tendinopathy

Rupe,

Fleury,

Glass

et al. 2023

Journal of Hand Surgery Global Online

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“…The double-blind placebo-controlled study in 2021 had shown one-year efficacy of single-dose ultrasound-guided perineural injection with PRP in patients with moderate-to-severe CTS compared with NS injection [ 50 ]. Recently, Shen et al [ 51 ] revealed less body weight, decreased distal motor latency and CSA of the MN predict better outcome after perineural injection of PRP for moderate CTS in 3 to 6 months follow-up.…”

Section: Novel Motor-sparing Neural Injection For Ctsmentioning

confidence: 99%

Novel Motor-Sparing Ultrasound-Guided Neural Injection in Severe Carpal Tunnel Syndrome: A Comparison of Four Injectates

Lam

Lai

et al. 2022

BioMed Research International

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Nerve hydrodissection uses fluid injection under pressure to selectively separate nerves from areas of suspected entrapment; this procedure is increasingly viewed as potentially useful in treating carpal tunnel syndrome (CTS). The usage of normal saline (NS), 5% dextrose water (D5W), platelet-rich plasma (PRP), and hyaluronic acid (HA) as primary injectates for hydrodissection without an anesthetic can limit anesthetic-related toxicity and preserve the motor functions of the median nerve. Here, we describe a novel motor-sparing neural injection and compare the effect of these four injectates for severe CTS. We retrospectively reviewed the outcomes of 61 severe CTS cases after a single neural injection with NS, D5W, PRP, or HA. Outcomes were evaluated on the 1st and 6th months postinjection, including the Boston Carpal Tunnel Questionnaire (BCTQ) scores and the nerve cross-sectional area (CSA). The results revealed that PRP, D5W, and HA were more efficient than NS at all measured time points ( p < 0.05 ), except for CSA at the 1st month between the NS and D5W groups. Single-injections of PRP and D5W seemed more effective than that of HA within 6 months postinjection for symptom and functional improvement (6th-month BCTQ-symptom, D5W vs. HA, p = 0.047 ; 1st-month BCTQ-symptom, PRP vs. HA, p = 0.018 ; 1st- and 6th-month BCTQ-function, D5W vs. HA, p = 0.002 and 0.016, respectively; 1st-month BCTQ-function, PRP vs. HA, p < 0.001 ). For reducing CSA, PRP and HA seemed more effective than D5W ( HA > PRP > D 5 W on the 1st month and HA vs. D5W, p = 0.001 ; PRP > HA > D 5 W on the 6th month and PRP vs. D5W, p = 0.012 ).

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Outcome predictors of platelet‐rich plasma injection for moderate carpal tunnel syndrome

Cited by 6 publications

References 52 publications

The Efficacy and Mid-term Durability of Urethral Sphincter Injections of Platelet-Rich Plasma in Treatment of Female Stress Urinary Incontinence

The Efficacy and Mid-term Durability of Urethral Sphincter Injections of Platelet-Rich Plasma in Treatment of Female Stress Urinary Incontinence

Efficacy of Ultrasonic Tenotomy and Debridement and Platelet-Rich Plasma Injections for Lateral Elbow Tendinopathy

Novel Motor-Sparing Ultrasound-Guided Neural Injection in Severe Carpal Tunnel Syndrome: A Comparison of Four Injectates

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