Outcome prediction in brain tumor surgery: a literature review on the influence of nonmedical factors

Schiavolin, Silvia; Raggi, Alberto; Scaratti, Chiara; Toppo, Claudia; Silvaggi, Fabiola; Sattin, Davide; Broggi, Morgan; Ferroli, Paolo

doi:10.1007/s10143-020-01289-0

Cited by 8 publications

(6 citation statements)

References 26 publications

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“…Furthermore, concerning pre-operative neurological deficits, they found that high-grade gliomas and language deficits were associated with worse outcomes. In this study, the pre-operative deficit associated with the worst outcome was motor deficit [20].…”

Section: Discussionmentioning

confidence: 73%

“…When analyzing in-hospital postoperative complications, it is possible to highlight that the most frequent complication was CSF leak, representing 21% of cases, followed by sepsis, which accounted for 18% of cases. Unlike other case series in which surgical site infection represents a large percentage of complications [16], the absence of post-hospital follow-up in this series explains why such complication was not included, as it typically manifests after hospital discharge [19,20]. The variables with statistical significance associated with complications were male sex, presence of motor deficit at admission, tumor type (high-grade gliomas cause more complications), and hypertension.…”

Section: Discussionmentioning

confidence: 91%

“…There was also a statistical relevance regarding lower GCS and a higher number of deficits on admission, both of which were associated with risk factors for complications in the in-hospital postoperative period. Schiavolin et al (2020), in a study carried out in Italy, evaluated the risk factors associated with worse outcomes in patients surgically treated for brain tumors. In this study, they found that males have a higher risk of unfavorable outcomes, as evidenced in this series.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological Profile of Adult Patients with Surgically Treated Intracranial Neoplasms

Simas,

Santos,

Couto

et al. 2024

JAMMR

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Aims: The American Cancer Society,s estimates for brain and spinal cord tumors in the United States for 2023, include both adults and children,25,400 malignant tumors will be diagnosed. The objective of this study was to analyze the epidemiological profile, risk factors for complications and death in the in-hospital postoperative period, in addition to describing the histological type of intracranial tumors most frequently operated on in a private Brazilian institution. Study Design: Retrospective cohort study. Place and Duration of Study: Biocor Instituto/Rede D’Or, from 2018 to 2021 Methodology: Data were collected from the medical records of patients who underwent surgery for intracranial tumors. The variables analyzed in this study were demographic characteristics (age, sex, and comorbidities), histological types of primary and secondary neoplasms, anatomical location of the lesions, neurological deficits at admission and post-surgical treatment (at discharge), whether the surgery was urgent or elective, whether it was a reoperation, and whether there were deaths or complications during hospitalization. Results: Of 242 patients, 11 patients were excluded, and 231 patients were included in the analysis. The most common histological type was meningioma, accounting for 28% of cases. The histological type most associated with the risk of death was hemangioblastoma; however, it was also the histological type that presented the lowest incidence of cases. 39 patients (17%) had some complication in the in-hospital postoperative period, and 14 patients (6%) died. Conclusions: Meningiomas constituted the majority of cases, accounting for 28% of the sample. The rate of complications and mortality was higher when compared to data from the international literature because this series analyzed brain metastases together with the excision of primary tumors. Concerning in-hospital deaths, hemangioblastoma emerged as the histological type most associated with the risk of death. It is noteworthy, however, that hemangioblastoma also exhibited the lowest incidence among the various histological types.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Epidemiological Profile of Adult Patients with Surgically Treated Intracranial Neoplasms

Simas,

Santos,

Couto

et al. 2024

JAMMR

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“…Social outcomes, including participation in the community, having contact with friends and family and the ability to live independently (World Health Organization, 2001) have all been evidenced as being affected negatively by brain injury (Corrigan et al, 2014;Dolecek et al, 2012;Wilson et al, 2017). There is consistent evidence that older age at time of injury was associated with poorer outcomes in these areas (Bartholomé & Winter 2020;Chan et al, 2013;Corrigan et al, 2014;Dolecek et al, 2012;Frost et al, 2013;Gittleman et al, 2018;Peeters et al, 2015;Ponsford, 2013;Roy-O'Reilly & McCullough, 2018;Schiavolin et al, 2020;Wardlaw et al, 2018;Wilson et al, 2017).…”

Section: Social Outcomesmentioning

confidence: 99%

A literature review of outcome and treatment options after acquired brain injury: Suggestions for adult offenders using knowledge from the general population

de Geus,

Milders,

van Horn

et al. 2024

Criminal Behav Ment Health

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BackgroundAcquired brain injury (ABI) is a major health problem, often with negative effects on behaviour and mental health as well as cognition. Prevalence of ABI is exceptionally high among offenders and increases their re‐offending risk. Information on risk factors for ABI and its outcomes among offenders that could guide effective treatment for them is, nevertheless, scarce and dispersed. However, there is a more substantial literature about the general population that could inform work with brain‐injured offenders, especially when selecting for samples or subgroups with similar relevant characteristics, such as lower socio‐economic status (SES), pre‐injury lower tested intelligence score (<85) and pre‐injury mental health problems.AimsTo explore brain injury data from non‐offender samples of otherwise similar socio‐economic and mental health and ability characteristics to offenders then, first, to describe their untreated outcomes and, secondly, outcomes after frequently used interventions in these circumstances, noting factors associated with their effectiveness.MethodThree databases were systematically searched for the years 2010–2022; first, using terms for brain injury or damage and cognitive (dys)function, mental health or quality of life. Second, in a separate search, we used these terms and terms for interventions and rehabilitation. In the second review, studies were selected for clear, distinguishable data on age, sex, SES and lifestyle factors to facilitate inferences for offenders. A narrative analytical approach was adopted for both reviews.ResultsSamples with characteristics that are typical in offender groups, including lower SES, lower pre‐injury intelligence quotient (<85), prior cognitive impairments and prior mental health problems, had poorer cognitive and behavioural outcomes following ABI than those without such additional problems, together with lower treatment adherence. With respect to treatment, adequate motivation and self‐awareness were associated with better cognitive and behavioural outcomes than when these were low or absent, regardless of the outcome measured.ConclusionsMore complex pre‐injury mental health problems and social disadvantages typical of offenders are associated with poorer post‐brain injury recovery. This paper adds to practical knowledge by bringing together work that follows specific outcome trajectories. Overall, succesful ABI‐interventions in the general population that aim at pre‐injury difficulties comparable to those seen among offenders, show that personalising injury‐specific treatments and taking account of these difficulties, maximised positive outcomes.

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“…However, the same study reported discrete impairments in about 50% of patients in memory and executive functions. Importantly, previous evidence indicated that poorer cognitive functioning is associated with lower quality of life (Boele et al, 2014) difficulties in daily functioning (Gonen et al, 2017; Schiavolin et al, 2021, 2022), and worse outcomes after surgery (Schiavolin et al, 2021). In this sense, Moritz‐Gasser et al (2012) showed that the speed of lexical access significantly correlates with the return to professional activities after awake surgery in people with low‐grade gliomas.…”

Section: Introductionmentioning

confidence: 98%

Understanding language and cognition after brain surgery – Tumour grade, fine‐grained assessment tools and, most of all, individualized approach

Gasa‐Roqué,

Rofes,

Simó

et al. 2023

Journal of Neuropsychology

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Cognitive performance influences the quality of life and survival of people with glioma. Thus, a detailed neuropsychological and language evaluation is essential. In this work, we tested if an analysis of errors in naming can indicate semantic and/or phonological impairments in 87 awake brain surgery patients. Secondly, we explored how language and cognition change after brain tumour resection. Finally, we checked if low‐tumour grade had a protective effect on cognition. Our results indicated that naming errors can be useful to monitor semantic and phonological processing, as their number correlated with scores on tasks developed by our team for testing these domains. Secondly, we showed that – although an analysis at a whole group level indicates a decline in language functions – significantly more individual patients improve or remain stable when compared to the ones who declined. Finally, we observed that having LGG, when compared with HGG, favours patients' outcome after surgery, most probably due to brain plasticity mechanisms. We provide new evidence of the importance of applying a broader neuropsychological assessment and an analysis of naming errors in patients with glioma. Our approach may potentially ensure better detection of cognitive deficits and contribute to better postoperative outcomes. Our study also shows that an individualized approach in post‐surgical follow‐ups can reveal reassuring results showing that significantly more patients remain stable or improve and can be a promising avenue for similar reports. Finally, the study captures that plasticity mechanisms may act as protective in LGG versus HGG after surgery.

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Outcome prediction in brain tumor surgery: a literature review on the influence of nonmedical factors

Cited by 8 publications

References 26 publications

Epidemiological Profile of Adult Patients with Surgically Treated Intracranial Neoplasms

Epidemiological Profile of Adult Patients with Surgically Treated Intracranial Neoplasms

A literature review of outcome and treatment options after acquired brain injury: Suggestions for adult offenders using knowledge from the general population

Understanding language and cognition after brain surgery – Tumour grade, fine‐grained assessment tools and, most of all, individualized approach

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