2017
DOI: 10.1684/epd.2017.0929
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Outcome of vagus nerve stimulation for drug‐resistant epilepsy: the first three years of a prospective Japanese registry

Abstract: Aims. Vagus nerve stimulation (VNS) is an established option of adjunctive treatment for patients with drug-resistant epilepsy, however, evidence for long-term efficacy is still limited. Studies on clinical outcomes of VNS in Asia are also limited. We report the overall outcome of a national, prospective registry that included all patients implanted in Japan. Methods. The registry included patients of all ages with all seizure types who underwent VNS implantation for drug-resistant epilepsy in the first three … Show more

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Cited by 87 publications
(75 citation statements)
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“…The clinical application of VNS was started based on the fundamental researches in an animal model in the United States in 1988, and health insurance coverage for VNS was applicable in Japan in 2010. 1,2) Several large clinical trials have demonstrated the results of VNS; thus, there is no room for doubt in terms of its effectiveness in the treatment of intractable epilepsy. 3,4) In addition, improvement of the cognitive function and emotional disorder has been known as a parallel effect associated with the restraint of epileptic seizures using VNS.…”
Section: Introductionmentioning
confidence: 99%
“…The clinical application of VNS was started based on the fundamental researches in an animal model in the United States in 1988, and health insurance coverage for VNS was applicable in Japan in 2010. 1,2) Several large clinical trials have demonstrated the results of VNS; thus, there is no room for doubt in terms of its effectiveness in the treatment of intractable epilepsy. 3,4) In addition, improvement of the cognitive function and emotional disorder has been known as a parallel effect associated with the restraint of epileptic seizures using VNS.…”
Section: Introductionmentioning
confidence: 99%
“…Cervical vagus nerve stimulation (VNS) is an FDA-approved treatment of drug-resistant epilepsy (Nune et al, 2015) and therapy-refractory major depression (Cristancho et al, 2011). The effectiveness of invasive cervical VNS in patients with drug-resistant epilepsy has been demonstrated repeatedly (Pakdaman et al, 2016;Kawai et al, 2017;Vivas et al, 2017). Furthermore, some initial trials on noninvasive transcutaneous auricular VNS reported promising results (He et al, 2013;Bauer et al, 2016;Barbella et al, 2018), although not all studies demonstrated effectiveness (Song et al, 2018).…”
Section: Introductionmentioning
confidence: 99%
“…Studies show a mean seizure frequency reduction by 26% after 1 year, 30% after 5 years, and 52% after 12 years with VNS treatment . In a recent Japanese study, seizure control improved over time with median seizure reduction of 25.0%, 40.9%, 53.3%, 60.0%, and 66.2% and responder rates of 38.9%, 46.8%, 55.8%, 57.7%, and 58.8% at 3, 6, 12, 24, and 36 months of VNS therapy, respectively …”
Section: Discussionmentioning
confidence: 95%