Outcome of urethral stent placement for management of urethral obstruction secondary to transitional cell carcinoma in dogs: 19 cases (2007–2010)

McMillan, Sara K.; Knapp, Deborah W.; Ramos‐Vara, José A.; Bonney, Patty L.; Adams, Larry G.

doi:10.2460/javma.241.12.1627

Cited by 62 publications

(64 citation statements)

References 13 publications

(10 reference statements)

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“…Local control is frequently challenging, and mortality most commonly occurs because of urinary tract obstruction or clinical signs associated with the primary tumor. The improved availability of stenting has led to additional treatment options for obstructive TCC 11, 12…”

mentioning

confidence: 99%

Randomized Phase III Trial of Piroxicam in Combination with Mitoxantrone or Carboplatin for First‐Line Treatment of Urogenital Tract Transitional Cell Carcinoma in Dogs

Allstadt

Rodríguez

Boostrom

et al. 2015

Veterinary Internal Medicne

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BackgroundReported response rates of transitional cell carcinoma (TCC) in dogs to piroxicam in combination with either mitoxantrone or carboplatin are similar; however, it is unknown whether either drug might provide superior duration of response.Hypothesis/ObjectivesTo determine if the progression‐free interval (PFI) of dogs with TCC treated with mitoxantrone and piroxicam was different than that of dogs receiving carboplatin and piroxicam. The hypothesis was that the efficacy of mitoxantrone is no different from carboplatin.AnimalsFifty dogs with TCC without azotemia.MethodsProspective open‐label phase III randomized study. Either mitoxantrone or carboplatin was administered every 3 weeks concurrently with piroxicam with restaging at 6‐week intervals. Twenty‐four dogs received carboplatin and 26 received mitoxantrone.ResultsResponse was not different between groups (P = .56). None of the dogs showed complete response. In the mitoxantrone group, there were 2 (8%) partial responses (PR) and 18 (69%) dogs with stable disease (SD). In the carboplatin group, there were 3 PR (13%) and 13 (54%) dogs with SD. The PFI was not significantly different between groups (mitoxantrone = 106 days; carboplatin = 73.5 days; P = .62; hazard ratio 0.86; 95% confidence interval 0.47–1.56). Dogs with prostatic involvement experienced a shorter survival (median, 109 days) compared to dogs with urethral, trigonal, or apically located tumors; this difference was significant (median 300, 190, and 645 days, respectively; P = .005).Conclusions and Clinical ImportanceThis study did not detect a different in outcome in dogs with TCC treated with either mitoxantrone or carboplatin in combination with piroxicam.

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confidence: 99%

Randomized Phase III Trial of Piroxicam in Combination with Mitoxantrone or Carboplatin for First‐Line Treatment of Urogenital Tract Transitional Cell Carcinoma in Dogs

Allstadt

Rodríguez

Boostrom

et al. 2015

Veterinary Internal Medicne

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“…urine leakage [2][3][4]73]. Given the morbidity associated with these techniques, palliative treatment in the form of urethral stenting and ultrasound-guided laser ablation of LUT tumors has gained popularity [2][3][4]74].…”

Section: Urethral Stentingmentioning

confidence: 99%

“…Given the morbidity associated with these techniques, palliative treatment in the form of urethral stenting and ultrasound-guided laser ablation of LUT tumors has gained popularity [2][3][4]74]. Urethral stents are most commonly placed in dogs and cats for the relief of obstruction due to malignant neoplasia, but have also been placed for treatment of urethral strictures, granulomatous and proliferative urethritis, and other benign diseases [2][3][4].…”

Section: Urethral Stentingmentioning

confidence: 99%

“…Urethral obstruction without rupture is often a cause for presentation of a small animal for urgent care, and results most commonly from urolithiasis, although neoplasia and trauma may also result in obstruction [1][2][3][4]. Even though calculi may develop within the urethra as urethroliths in both male and female dogs and cats, urocystoliths developing in the urinary bladder may also pass into the urethra and cause complete or partial obstruction to urine flow and associated clinical signs.…”

Section: Introductionmentioning

confidence: 99%

“…Partial or complete rupture of the urethra can result from the presence of obstructive urethral calculi, iatrogenically from attempts at catheterization to relieve the obstruction or from surgery in the area to remove calculi and obstructive material [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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