Outcome of upper gastro-intestinal bleeding and use of ibuprofen versus paracetamol

Abstract

UGIB patients with antecedent ibuprofen prescriptions experienced about the same case fatality rates, but more surgery and longer hospital stays, than patients prescribed paracetamol. The differences appear in part due to differing characteristics among those prescribed ibuprofen compared with those prescribed paracetamol, but also raise the possibility of drug-related effects.

Chronic liver disease and 90-day mortality in 21 359 patients following peptic ulcer bleeding - a Nationwide Cohort Study

“…The Danish National Health Service Prescription Registry contains information on all redeemed prescriptions for reimbursed medications in Denmark . We ascertained current use (defined as at least one redeemed prescription within 90 days of the current hospitalisation) of histamine‐2 receptor antagonists, prostaglandin analogues, proton pump inhibitors, non‐steroidal anti‐inflammatory drugs (NSAIDs), systemic glucocorticoids, acetaminophen, aspirin, vitamin‐K antagonists, antidepressants and antipsychotic drugs (for specific Anatomical Therapeutic Chemical classification system codes, see Appendix S1) …”

“…28 We ascertained current use (defined as at least one redeemed prescription within 90 days of the current hospitalisation) of histamine-2 receptor antagonists, prostaglandin analogues, proton pump inhibitors, non-steroidal anti-inflammatory drugs (NSA-IDs), systemic glucocorticoids, acetaminophen, aspirin, vitamin-K antagonists, antidepressants and antipsychotic drugs (for specific Anatomical Therapeutic Chemical classification system codes, see Appendix S1). 32,[35][36][37][38][39][40] Mortality data We followed patients from date of hospital admission with peptic ulcer bleeding until death, emigration, or up to 90 days or end of study, whichever came first. Data on all-cause mortality were obtained from the Danish Civil Registration System, which contains records of changes in migration and vital status for the entire Danish population since 1968, electronically updated on a daily basis.…”

Prescriptions for selective cyclooxygenase-2 inhibitors, non-selective non-steroidal anti-inflammatory drugs, and risk of breast cancer in a population-based case-control study

“…We also retrieved prescriptions for post-menopausal hormone replacement therapy (G03C, G03D, G03F, G03HB01), since use of hormone replacement therapy increases the risk of breast cancer [69-71] and women who adhere to one medication may also be more likely to adhere to other prescription medications, such as NSAIDs [72]. Although acetaminophen is mainly obtained over the counter in Denmark, we also investigated the impact of prescribed acetaminophen (N02BE51) use on breast cancer risk as a comparison analysis [73]. …”

Outcome of peptic ulcer bleeding among users of traditional non‐steroidal anti‐inflammatory drugs and selective cyclo‐oxygenase‐2 inhibitors

“…The newer COX‐2 inhibitors identified were celecoxib (M01AH01), rofecoxib (M01AH02), etoricoxib (M01AH05), etodolac (M01AB08) and meloxicam (M01AC06). Similarly, we identified all users of several other drugs associated with peptic ulcer bleeding: 10, 22–26 low‐ or high‐dose aspirin (B01AC06, N02BA01, N02BA51), systemic glucocorticoids (H02AB), paracetamol (N02BE01, N02BE51), vitamin K antagonists (B01AA03, B01AA04), calcium channel blockers (C08) and antidepressants (N06A). We also identified users of anti‐ulcer drugs, i.e.…”