Outcome of Two Corneal Collagen Crosslinking Methods in Bullous Keratopathy due to Fuchs’ Endothelial Dystrophy

Uçakhan, Ömür Ö.; Sağlık, Ayhan

doi:10.1155/2014/463905

Cited by 10 publications

(4 citation statements)

References 12 publications

(17 reference statements)

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“…The histological analysis of BK post-CXL was reported by Arora et al [29] as they performed penetrating keratoplasty either 1 or 3 months after CXL in both groups, allowing histological analysis [30][31][32]. They also found insufficient improvements to VA post-CXL (1.925 ± 0.173 logMAR to 1.75 ± 0.296 at 1 month (p = 0.01) to 1.81 ± 0.23 at 3 months).…”

Section: Bullous Keratopathymentioning

confidence: 95%

Use of corneal cross-linking beyond keratoconus: a systemic literature review

Achiron

Knyazer

Elhaddad

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Purpose The success of corneal collagen cross-linking in altering keratoconus' clinical course has driven a search for further uses of this procedure. This literature review aims to analyze the scientific evidence available for the benefit of cross-linking in the management of ophthalmic diseases other than progressive keratoconus or ectasia induced by corneal refractive procedures. Methods A systemic literature review. ResultsWe reviewed 97 studies. We found that collagen cross-linking can limit the progression of several other corneal ectasias, thus reducing and limiting the need for keratoplasty. Collagen cross-linking also can reduce the refractive power of the cornea and can be considered for a moderate degree of bacterial keratitis or when the organism is unidentified, which is refractive to antibiotics alone. However, the comparative rarity of these procedures has limited the extent of evidence. In fungal, Acanthamoeba, and herpes virus keratitis, the evidence is inconclusive of the safety and efficacy of cross-linking. Conclusion Current clinical data is limited, and laboratory data has not fully correlated with published clinical data.

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Section: Bullous Keratopathymentioning

confidence: 95%

Use of corneal cross-linking beyond keratoconus: a systemic literature review

Achiron

Knyazer

Elhaddad

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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“…However, there is no established evidence of effectiveness of CXL in these conditions. Some authors claim its benefit in non-healing ulcer and symptomatic PBK while others consider this treatment ineffective 11,12…”

Section: Introductionmentioning

confidence: 99%

“…Some authors claim its benefit in non-healing ulcer and symptomatic PBK while others consider this treatment ineffective. 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

Determining the efficacy of corneal crosslinking in progressive keratoconus

et al. 2017

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Objective:To determine the Efficacy of Corneal Crosslinkage (CXL), using Corneal Topography, in eyes with progressive Keratoconus.Methods:This randomized control trial was conducted at Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan from October 2013 to April 2014. A total of 60 eyes of 30 patients were included who presented with bilateral progressive Keratoconus. Each eye of the patient was randomized either to a treatment group (Group-A) or control untreated group (Group-B) of 30 eyes each. A written informed consent was obtained from each patient, following which corneal crosslinkage (CXL) with topical riboflavin eye drops was performed. Follow up visit was done at three months post operatively, Corneal topography was repeated and recorded.Results:The mean age of the patients was 23.13±7.62 years (range 13 to 39 years). There were 26 males and 34 females patients. The mean simK value at the start of study was 50.94±4.84 diopters in Group-A and 49.73±5.24 diopters in Group-B. At three months follow-up, the mean simK value was significantly lower in Group-A (48.28±4.47) as compared to Group-B (51.11±4.85). Keratoconus improved/ remained stable in 34 (56.7%) eyes while progressive disease was noted in 26 (43.3%) eyes. When compared between the groups, the frequency of efficacy was significantly higher in Group-A (86.7% vs. 26.7%; p=.000) as compared to Group-B.Conclusion:Corneal Crosslinking was found effective in causing regression or halting the progression of disease in patients with progressive Keratoconus at three months follow-up, however, the efficacy of corneal crosslinking was unaffected by patient’s age and gender.

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“…Although outside the scope of this thesis, it is worth mentioning the application of CXL in ophthalmology reaches further than ectatic disorders. Other investigated corneal indications of (mainly RF/UVA or RB/GL) CXL include pellucid marginal degeneration [126][127][128][129][130][131][132][133][134] , Terrien's marginal degeneration 135,136 , bullous keratopathy [137][138][139][140][141][142][143][144][145][146][147][148][149][150][151][152][153][154][155] , chemical burns [156][157][158][159][160] , melting keratoprosthesis [161][162][163] , corneal lacerations [164][165][166] and radial keratotomy 167,168 , brittle cornea syndrome 169 , as pre-treatment for corneal donor tissue [170]…”

Section: Alternative Indications For Cross-linkingmentioning

confidence: 99%

New developments in the treatment of corneal ectatic disorders

Brekelmans¹

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Outcome of Two Corneal Collagen Crosslinking Methods in Bullous Keratopathy due to Fuchs’ Endothelial Dystrophy

Cited by 10 publications

References 12 publications

Use of corneal cross-linking beyond keratoconus: a systemic literature review

Use of corneal cross-linking beyond keratoconus: a systemic literature review

Determining the efficacy of corneal crosslinking in progressive keratoconus

New developments in the treatment of corneal ectatic disorders

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