Outcome of twin pregnancies associated with glucose intolerance

Poulain, Chloe; Duhamel, Alain; Garabédian, Charles; Cazaubiel, M.; Réjou, M.-C.; Vambergue, A.; Deruelle, Philippe

doi:10.1016/j.diabet.2014.12.005

Cited by 17 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In light of this, we have examined the data at our institution (Royal North Shore Hospital, Sydney, Australia) and identified 49 women with GDM in twin pregnancy within the previous 5 years (2012-2017). We observed an SGA rate of 24.5% for twins born to mothers with GDM (of n 5 94 live births) and no LGA neonates, which is in keeping with the current study (1) and several others, where the incidence of SGA neonates ranged between 7.8% and 34.5% (2,3).…”

supporting

confidence: 92%

Comment on Ooi and Wong. Twin Pregnancy With Gestational Diabetes Mellitus: A Double Whammy? Diabetes Care 2018;41:e15–e16

2018

View full text Add to dashboard Cite

supporting

confidence: 92%

Comment on Ooi and Wong. Twin Pregnancy With Gestational Diabetes Mellitus: A Double Whammy? Diabetes Care 2018;41:e15–e16

2018

View full text Add to dashboard Cite

“…When compared with twin pregnancies without GDM, no difference in cesarean delivery rates was seen in twins with GDM (Okby et al, 2014;Simoes et al, 2011). One study even reported significantly lower rates of cesarean delivery in twin pregnancies with glucose intolerance (Poulain et al, 2015). However, the diagnostic criteria used in this study were not consistent with IADPSG, and thus, it is difficult to compare these results against our cohort.…”

Section: Discussionmentioning

confidence: 69%

Does Gestational Diabetes Cause Additional Risk in Twin Pregnancy?

et al. 2019

View full text Add to dashboard Cite

It has been suggested that the risk of adverse perinatal outcomes in twin pregnancies is exacerbated by concomitant gestational diabetes mellitus (GDM). This study aimed to assess the risk incurred by twin pregnancy and by a diagnosis of GDM, separately, on the development of poor perinatal outcomes. A retrospective cohort study was conducted on all pregnant women at a tertiary center between 2016 and 2017. The impact of GDM and twin pregnancies on perinatal outcomes — birth weight above the 90th centile for gestational age, cesarean delivery, clinical neonatal hypoglycemia, and premature delivery (before 37 weeks’ gestation) — was assessed using univariate and multivariate analyses. Overall, 13,527 women were eligible for the study; 11,915 were uncomplicated singleton pregnancies; 1379 of these had GDM; 194 were twin pregnancies, and 39 of these had GDM. Univariate analyses showed that twin pregnancies were associated with a higher risk of all perinatal outcomes except macrosomia. In the multivariate analyses, twin pregnancy was a much higher predictor of cesarean delivery (OR 8.40, 95% CI [6.25, 11.49], p < .0001) and preterm birth (OR 58.82, 95% CI [31.25, 125], p < .0001) compared to GDM but GDM was a higher predictor of neonatal hypoglycemia (OR 4.87, 95% CI [3.74, 6.29], p < .0001). Twin pregnancy is more strongly associated with all adverse perinatal outcomes except macrosomia. GDM does not increase risk of adverse perinatal outcomes except for neonatal hypoglycemia.

show abstract

“…Studies that focused on the effects of GDM in twin pregnancies on perinatal outcomes presented even more conflicting results. In some studies, the rates of preterm birth 4,7,10 , LGA 7,8,10,12 , macrosomia 4,7 , birth trauma 7 , perinatal death 7 , neonatal jaundice 10 , respiratory distress 13,14 and neonatal intensive care unit (NICU) admission 3,9,14 were higher in women with GDM with twin pregnancies than in those without GDM; on the contrary, other studies found no differences in most major perinatal outcomes, such as preterm birth 6,9,15 , LGA 5,9,11,15 , low 5‐min Apgar score (<7) 9,15 and perinatal death 9,15,16 between GDM and non‐GDM twins. Some studies even revealed better outcomes, along with reducing risk for small‐for‐gestational age (SGA) infants, preterm birth <32 gestational weeks, low 5‐min Apgar score and perinatal mortality 6,17 .…”

Section: Introductionmentioning

confidence: 97%

“…Several studies concluded that women with twin pregnancies who were complicated by GDM are at an increased risk for gestational hypertension and pre‐eclampsia compared with women with twin pregnancies, but without GDM 3–9 . Some studies further found that these women also had higher rates of cesarean deliveries (CS) 8,10 and induction of labor 6 , whereas others did not show similar findings 7,9,11 . Studies that focused on the effects of GDM in twin pregnancies on perinatal outcomes presented even more conflicting results.…”

Section: Introductionmentioning

confidence: 99%

Risk factors and adverse maternal and perinatal outcomes for women with dichorionic twin pregnancies complicated by gestational diabetes mellitus: A retrospective cross‐sectional study

Hung

Hsieh

Shaw

et al. 2020

J of Diabetes Invest

View full text Add to dashboard Cite

Aims/Introduction The association between gestational diabetes mellitus (GDM) and adverse maternal and perinatal outcomes in twin pregnancies remains unclear. This study was undertaken to highlight risk factors for GDM in women with dichorionic (DC) twins, and to determine the association between GDM DC twins and adverse maternal and perinatal outcomes in a large homogeneous Taiwanese population. Materials and Methods A retrospective cross‐sectional study was carried out on 645 women with DC twins, excluding pregnancies complicated by one or both fetuses with demise (n = 22) or congenital anomalies (n = 9), who gave birth after 28 complete gestational weeks between 1 January 2001 and 31 December 2018. Univariable and multiple logistic regression analyses were carried out. Results Maternal age >34 years (adjusted odds ratio 2.52; 95% confidence interval 1.25–5.07) and pre‐pregnancy body mass index >24.9 kg/m2 (adjusted odds ratio 2.83, 95% confidence interval 1.47–5.46) were independent risk factors for GDM in women with DC twins. Newborns from women with GDM DC twins were more likely to be admitted to the neonatal intensive care unit (adjusted odds ratio 1.70, 95% confidence interval 1.06–2.72) than newborns from women with non‐GDM DC twins. Other pregnancy and neonatal outcomes were similar between the two groups. Conclusions Advanced maternal age and pre‐pregnancy overweight or obesity are risk factors for GDM in women with DC twins. Except for a nearly twofold increased risk of neonatal intensive care unit admission of newborns, the pregnancy and neonatal outcomes for women with GDM DC twins are similar to those for women with non‐GDM DC twins.

show abstract

Outcome of twin pregnancies associated with glucose intolerance

Cited by 17 publications

References 28 publications

Comment on Ooi and Wong. Twin Pregnancy With Gestational Diabetes Mellitus: A Double Whammy? Diabetes Care 2018;41:e15–e16

Comment on Ooi and Wong. Twin Pregnancy With Gestational Diabetes Mellitus: A Double Whammy? Diabetes Care 2018;41:e15–e16

Does Gestational Diabetes Cause Additional Risk in Twin Pregnancy?

Risk factors and adverse maternal and perinatal outcomes for women with dichorionic twin pregnancies complicated by gestational diabetes mellitus: A retrospective cross‐sectional study

Contact Info

Product

Resources

About