Outcome of twin pregnancies after amniocentesis

Kan, Anita Sik Yau; Lee, Chin Peng; Leung, Kwok; Chan, Ben; Tang, Mary Hoi Yin; Chan, Vivian Ho Yan

doi:10.1111/j.1447-0756.2011.01721.x

Cited by 10 publications

(19 citation statements)

References 31 publications

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“…Other studies have reported a very low rate of fetal loss following amniocentesis in twin pregnancies. For example, Kan and colleagues in Hong Kong reported in 2012 that out of 105 twin pregnancies, 102 gave birth to live babies (Kan, Lee, Leung, Chan, Tang, & Chan, 2012). However, in some other studies, the results have been reported to be inconsistent with the present study, and contrary to our findings, amniocentesis has increased the rate of fetal loss in patients.…”

Section: Discussioncontrasting

confidence: 99%

Risk of Fetal Loss after Amniocentesis in Twins Comparing with Singleton Pregnancy

Masihi¹,

Shahbazian²,

Barati³

et al. 2020

JMBR

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Introduction: Amniocentesis is one of the most widely used diagnostic interventions but despite its many advantages, it has side effects such as fetal loss. The importance of fetal loss after amniocentesis in twin pregnancies is very important and some researchers believe that in twin pregnancies, the risk of fetal loss after amniocentesis is higher than singleton. Therefore, the present study examined the rate of fetal loss after amniocentesis in twin pregnancies compared to singleton pregnancies. Methods: This prospective descriptive-analytical study was performed on 712 mothers with singleton (628 cases) and twin (84 cases) pregnancies who referred to the obstetrics and gynecology clinic of Imam Khomeini Hospital in Ahvaz with Amniocentesis due to several reason during 2016-2020. A questionnaire containing information such as age, gestational age, number of pregnancies, childbirth and abortion, the cause of the diagnostic test, quarterly screening and NT ultrasound, and the result of amniocentesis were completed for patients. Patients were followed up during the first week, two weeks, and 60 days after amniocentesis, and finally data were analyzed by SPSS version24. Results: The mean age of the patients was 31.96 ± 6.33 years and the mean gestational age at amniocentesis for all patients was 15.37 ± 0.7. The mean NT in patients in the two groups did not differ significantly (1.60±0.44 vs 1.54±4.64, p=0.56). the prevalence of preterm in twin mothers was 13.1% and, in the singleton was 1.75% (p = 0.01). The occurrence of fetal loss was 2.4% in the twin group and 2.07% in the singleton group which was not statistically significant (p = 0.56). in the twin group, one (50%) fetal loss occurred in the first week and another one (50%) occurred between 15 and 60 days. But in the singleton group, 7 cases (63.6%) in the first week, 1 case (9%) in 15 to 60 days, and 3 cases (27.3) after more than 60 days lost the fetus. Previous pregnancy records in twins showed that the mean Gravid (p = 0.01), Parity (p = 0.01) and Living child (p = 0.02) in preterm twins' patients were statistically significantly lower than in the term patients. Conclusion: Our findings show that fetal loss following amniocentesis in twin pregnancies does not increase significantly compared to singleton pregnancies. However, our findings require repeated study in bigger sample size and as multi-centered as possible then It can be generalized to wider communities.

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Section: Discussioncontrasting

confidence: 99%

Risk of Fetal Loss after Amniocentesis in Twins Comparing with Singleton Pregnancy

Masihi¹,

Shahbazian²,

Barati³

et al. 2020

JMBR

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“…However, the accuracy of ultrasound detection declines dramatically due to thinner chorionicity in the second trimester [8]. Invasive approaches such as amniocentesis or cord blood sampling combined with microsatellite DNA markers could also detect zygosity with high accuracies, but it presents a potential miscarriage at a risk of 0.5–1% [9]. Thus there is a huge demand for a noninvasive method to accurately determine the zygosity type without the limitation of gestational age.…”

Section: Introductionmentioning

confidence: 99%

Effective Noninvasive Zygosity Determination by Maternal Plasma Target Region Sequencing

Zheng

Guo

et al. 2013

PLoS ONE

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BackgroundCurrently very few noninvasive molecular genetic approaches are available to determine zygosity for twin pregnancies in clinical laboratories. This study aimed to develop a novel method to determine zygosity by using maternal plasma target region sequencing.MethodsWe constructed a statistic model to calculate the possibility of each zygosity type using likelihood ratios (Li) and empirical dynamic thresholds targeting at 4,524 single nucleotide polymorphisms (SNPs) loci on 22 autosomes. Then two dizygotic (DZ) twin pregnancies,two monozygotic (MZ) twin pregnancies and two singletons were recruited to evaluate the performance of our novel method. Finally we estimated the sensitivity and specificity of the model in silico under different cell-free fetal DNA (cff-DNA) concentration and sequence depth.Results/ConclusionsWe obtained 8.90 Gbp sequencing data on average for six clinical samples. Two samples were classified as DZ with L values of 1.891 and 1.554, higher than the dynamic DZ cut-off values of 1.162 and 1.172, respectively. Another two samples were judged as MZ with 0.763 and 0.784 of L values, lower than the MZ cut-off values of 0.903 and 0.918. And the rest two singleton samples were regarded as MZ twins, with L values of 0.639 and 0.757, lower than the MZ cut-off values of 0.921 and 0.799. In silico, the estimated sensitivity of our noninvasive zygosity determination was 99.90% under 10% total cff-DNA concentration with 2 Gbp sequence data. As the cff-DNA concentration increased to 15%, the specificity was as high as 97% with 3.50 Gbp sequence data, much higher than 80% with 10% cff-DNA concentration.SignificanceThis study presents the feasibility to noninvasively determine zygosity of twin pregnancy using target region sequencing, and illustrates the sensitivity and specificity under various detecting condition. Our method can act as an alternative approach for zygosity determination of twin pregnancies in clinical practice.

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“…Increasing frequencies of multiple pregnancies and advanced maternal age have expanded the need for invasive prenatal diagnosis 123415. Fetal loss after invasive prenatal diagnostic tests is one of the major concerns of pregnant women.…”

Section: Discussionmentioning

confidence: 99%

“…These women who conceive a multiple pregnancy with ART are usually of more advanced maternal age. With increased age-related chromosomal abnormalities and the risk of aneuploidy per gestation in dizygotic twins, an increasing need is seen for prenatal diagnosis in multiple pregnancies 1345…”

Section: Introductionmentioning

confidence: 99%

“…Under certain circumstances, women with twin pregnancies (TPs) may be advised to undergo invasive prenatal diagnostic testing. Chorionic villus sampling (CVS) and amniocentesis (AC) are the two commonly performed invasive prenatal diagnostic testing 36. Indications for CVS and AC are chromosomal evaluation for advanced maternal age, pregnancies established after intracytoplasmic sperm injection, and chromosomal evaluation or DNA analysis for other indications, including history of monogenetic disease, presence of sonographic markers for fetal aneuploidy or fetal structural defects, chromosomal malformations in parents or previous pregnancies, and the psychological indications 7.…”

Section: Introductionmentioning

confidence: 99%

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Obstetrical Outcomes of Amniocentesis or Chorionic Villus Sampling in Dichorionic Twin Pregnancies

et al. 2019

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Background Under certain situations, women with twin pregnancies may be counseled to undergo invasive prenatal diagnostic testing. Chorionic villus sampling and amniocentesis are the two generally performed invasive prenatal diagnostic tests. Studies comparing procedure-related fetal loss between first-trimester chorionic villus sampling and second-trimester amniocentesis in twin pregnancies are limited. This study aimed to evaluate the procedure-related fetal loss and the obstetrical outcomes of these two procedures, chorionic villus sampling and amniocentesis in twin pregnancies. Methods The data from dichorionic-diamniotic twin pregnancies on which first-trimester chorionic villus sampling (n = 54) or second-trimester amniocentesis (n = 170) was performed between December 2006 and January 2017 in a single center were retrospectively analyzed. The procedure-related fetal loss was classified as loss of one or all fetuses within 4 weeks of procedure, and overall fetal loss was classified as loss of one or all fetuses during the gestation. The groups were compared with respect to the procedure-related and obstetrical outcomes. Results The difference in proportion of procedure-related fetal loss rate (1.9% for chorionic villus sampling vs. 1.8% for amniocentesis; P = 1.000) and the overall fetal loss rate (7.4% for chorionic villus sampling vs. 4.7% for amniocentesis; P = 0.489) between the two groups was not significant. The mean gestational ages at delivery were not statistically significant. Conclusion Both the overall fetal loss rate and the procedure-related fetal loss rate of chorionic villus sampling and amniocentesis in dichorionic twin pregnancies had no statistical significance. Both procedures can be safely used individually.

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Outcome of twin pregnancies after amniocentesis

Abstract: Our cohort showed a low fetal loss rate after amniocentesis for uncomplicated twin pregnancies.

Cited by 10 publications

References 31 publications

Risk of Fetal Loss after Amniocentesis in Twins Comparing with Singleton Pregnancy

Risk of Fetal Loss after Amniocentesis in Twins Comparing with Singleton Pregnancy

Effective Noninvasive Zygosity Determination by Maternal Plasma Target Region Sequencing

Obstetrical Outcomes of Amniocentesis or Chorionic Villus Sampling in Dichorionic Twin Pregnancies

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