Outcome of Surgical Treatment of Synchronous Liver Metastases from Colorectal Cancer

Abstract

Background: We retrospectively identified the prognostic factors in cases of synchronous

Patterns of chemotherapy-induced hepatic injury and their implications for patients undergoing liver resection for colorectal liver metastases

“…Surgical resection remains the globally accepted standard of care for patients with resectable colorectal liver metastases (CLM) and is the only treatment associated with long‐term survival and cure. Five‐year survival rates following resection of CLM have been reported to be in excess of 50% [] when hepatic resection is combined with chemotherapy but only 15–20% of patients with CLM are candidates for surgical resection at the time of presentation []. Historical data typically show poor response rates achieved with the combination of 5‐fluorouracil (5‐FU) and leucovorin on the order of 20% [9].…”

Chinese guidelines for the diagnosis and comprehensive treatment of hepatic metastasis of colorectal cancer

“…Most of these patients (about 80-90%) will not be suitable candidates for radical excision of their hepatic metastases. Hepatic metastases are therefore the most common cause of death for colorectal cancer patients (Foster 1984;Vibert et al 2005;Kemeny 2006;Lau and Lai 2007;Taniai et al 2007;Arru et al 2008). The median survival time for patients with untreated hepatic metastases is only 6.9 months, with a 5-year survival rate of 0% (Sharma et al 2008;Elias et al 2004).…”

Practical questions in liver metastases of colorectal cancer: general principles of treatment

“…The optimal timing of the surgical treatment of synchronous CLM is a matter of controversy 70–86. Studies that compared combined versus staged procedures demonstrated that the overall survival is similar, but the complication rate for the combined procedure was significantly less than for a staged procedure 70, 71 .…”