Outcome of surgery for ileojejunal neuroendocrine tumors

Habbe, Nils; Fendrich, Volker; Heverhagen, Anna E.; Ramaswamy, Annette; Bartsch, Detlef K.

doi:10.1007/s00595-012-0408-1

Cited by 21 publications

(24 citation statements)

References 21 publications

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“…15,17,18 The survival rate in our study for R0 resections is higher than that reported in other studies (55%-80%). 5,9,16,18 We attribute this improvement, in part, to the use of postoperative radioisotope therapy to minimize the risk of recurrence and control tumour growth. More than one-third of patients with distant disease received radioisotope therapy.…”

Section: Discussionmentioning

confidence: 99%

A population-based study of outcomes in patients with gastrointestinal neuroendocrine tumours

McMullen

Aljahdali

Gara

et al. 2017

CJS

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Background: Neuroendocrine tumours (NETs) are heterogeneous, with varying presentations and treatment options. To our knowledge, there are no randomized and few long-term studies of patient outcomes. The role of surgical and medical therapy for local, regional and metastatic disease continues to be evaluated in the literature. Methods:We conducted a population-based search of the provincial cancer registry to identify patients with gastrointestinal NETs from the stomach, small intestine, colon and rectum diagnosed between 1990 and 2005 and assessed their outcomes.

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Section: Discussionmentioning

confidence: 99%

A population-based study of outcomes in patients with gastrointestinal neuroendocrine tumours

McMullen

Aljahdali

Gara

et al. 2017

CJS

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“…Localized and regionally restricted (Stage I-III) Si-NENs have an excellent prognosis after radical surgical treatment. The importance of achieving R0 resection is therefore emphasized [94,95]. To limit the extent of small intestinal resection, lymphatic mapping has been suggested to be helpful, but it is not a standardized procedure and therefore not generally recommended [96,97].…”

Section: Resection Of Localized and Regional Disease (Stage I-iii)mentioning

confidence: 99%

ENETS Consensus Guidelines Update for Neuroendocrine Neoplasms of the Jejunum and Ileum

et al. 2016

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“…In patients with rectal NET tumor size >1 cm, infiltration of the muscularis propria, increased mitotic index, lymphovascular invasion and regional lymph node metastases were predictors of recurrence in a very recent trial [17]. For patients with NETs of other origin, no predictors of recurrence have been identified and data on overall outcome after surgery are also limited [6,18]. …”

Section: Introductionmentioning

confidence: 99%

“…The grading system based on the proliferation marker Ki-67 and TNM staging as proposed by ENETS have been demonstrated to be prognostic for overall survival (OS) [7,10,11]. Additional data exist for prognostic factors after surgery [6,12,13], but the analyses of risk factors for recurrent disease are limited. Recently, Strosberg et al [14] showed that staging of pancreatic NETs according to ENETS or AJCC is prognostic for recurrence.…”

Section: Introductionmentioning

confidence: 99%

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Well-Differentiated Neuroendocrine Neoplasia: Relapse-Free Survival and Predictors of Recurrence after Curative Intended Resections

Dieckhoff¹,

Runkel²,

Daniel³

et al. 2014

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Background: Resection with curative intention is the cornerstone of treatment in patients with neuroendocrine tumors. A proportion of patients will relapse after R0 resection, but the factors predictive of recurrence are not well understood. Methods: A database established 1998 at the University Hospital Marburg was queried for all patients with documented R0 resection. Recurrence-free survival and overall survival were estimated using the Kaplan-Meier method. Uni- and multivariate analyses were performed. Results: 180 patients with a median age of 52 years entered the analysis. We observed 77 recurrences after a median time of 2.9 years. 24% of the recurrences occurred later than 5 years after operation. Median recurrence-free survival of the whole cohort was 101 months. In univariate analysis grade by Ki-67, stage, high lymph node ratio and microangioinvasion were significant predictors of recurrence. On multivariate analysis these parameters were confirmed as independent prognostic parameters with stage and microangioinvasion being the most important predictors. Conclusions: After R0 resection of neuroendocrine tumors, postoperative surveillance should be extended to at least 10 years. Patients with distant metastases and microangioinvasion are at high risk of recurrence. Clinical trials of adjuvant treatment protocols are indicated in these patients.

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Outcome of surgery for ileojejunal neuroendocrine tumors

Abstract: Localized and regionally restricted ileojejunal NETs have an excellent prognosis after surgical treatment. Although stage IV tumors cannot be cured, an aggressive surgical approach in combination with medical or interventional treatment can provide long-term survival.

Cited by 21 publications

References 21 publications

A population-based study of outcomes in patients with gastrointestinal neuroendocrine tumours

A population-based study of outcomes in patients with gastrointestinal neuroendocrine tumours

ENETS Consensus Guidelines Update for Neuroendocrine Neoplasms of the Jejunum and Ileum

Well-Differentiated Neuroendocrine Neoplasia: Relapse-Free Survival and Predictors of Recurrence after Curative Intended Resections

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