Outcome of Structural Heart Disease Diagnosed In Utero

Boldt, Talvikki; Andersson, Sture; Eronen, Matti

doi:10.1080/140174302753675339

Cited by 53 publications

(65 citation statements)

References 17 publications

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“…These malformations had a more severe prognosis than existing cardiac pathology and therefore were the basic indication for TOP. There was a chromosomal anomaly incidence of 21.7% in our series, which is comparable to former studies (19)(20)(21). Additional systemic malformations are persuasive criteria for parents in making decisions regarding termination.…”

Section: Discussionsupporting

confidence: 77%

Counseling and outcomes of antenatally diagnosed congenital heart anomalies in Turkey

Gedikbaşı¹,

Öztarhan²,

Yıldırım³

et al. 2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Prenatal tanı almış, fetal kalp anomalilerinin, klinik sonuçları ve aile kararlarının değerlendirilmesi. Yöntemler: Prenatal doğumsal kalp anomali tanısı konmuş olgular (n=155), retrospektif yöntemle Allan ve Huggon'ın sınıflandırması doğrultu-sunda, Grup A (doğumsal kalp anomalisine eşlik eden ağır / ölümcül kalp dışı patoloji); Grup B1 (postnatal prognoz açısından düşük risk), Grup B2 (orta risk, düşük mortalite oranı ile uyumlu cerrahi mortalite) ve Grup B3 (yüksek risk-cerrahi sonrası için yüksek mortalite) olarak sınıflan-dırıldı. Ailelere verilen, danışma sonrası yenidoğan verileri, buna gebelik sonlandırması dahil edilmiştir ve 18 ay süreyle izlendi. Bulgular: Olguların 145'inin izlemi tam olarak gerçekleştirilmiştir. Otuz dokuz olguda (Grup A) eşlik eden ölümcül kalp dışı anomaliler saptanmış-tır ve bunların gebelik sonlandırılmasına karar verilmiştir; bu olgular istatistiksel değerlendirmeye alınmamıştır. Grup B3' teki olguların 20 tanesi de gebelik sonlandırmasına karar verdi. Diğer üç kalp anomalisi gruplarında, gebeliğin devamına karar veren ailelerde (Grup B1, n=37; Grup B2, n=12; Grup B3, n=37), 18 ayın sonunda sağkalım oranları sırasıyla %89.2, %66.7 ve %13.5 bulunmuştur. İstatistiksel verilerin değerlendirmesinde Student's t-test, Mann-Whitney U, Pearson's Ki-kare testi ve Fischer's exact Ki-kare testi uygulanmıştır. Sağkalım açısından 3 grupta istatistiksel anlamlılık saptanmıştır [Grup B3 ile Grup B1: p=0.0001; OR: 52.8 (12.9-214.5); Grup B3 ile Grup B2: p=0.0009; OR: 12.8 (2.8-58.9); Grup B2 ile Grup B1: p=0.087; OR: 4.12 (0.84-20.2)]. Sonuç: Uygulamalarımız ve istatistiksel sonuçlarımız, bu sınıflama sisteminin, doğumsal kalp anomalileri açısından ebeveynlere verilecek danış-mada etkili olduğunu gösterdi. ABSTRACTObjective: To determine the clinical outcomes and decisions of families of fetuses with prenatally-diagnosed cardiac abnormalities. Methods: Prenatally diagnosed cases (n=155) with congenital heart disease were retrospectively categorized according to the Allan-Huggon grading system: Group A (cardiac disease associated with severe / lethal extracardiac disease); Group B1 (low risk with a postnatal prognosis); Group B2 (moderate risk, amenable to surgical repair with a low mortality); and Group B3 (high risk, associated with high mortality after surgery). Neonatal outcomes, including termination of pregnancy, were recorded for 18 months of follow-up after counseling the parents. Student's t-test, Mann-Whitney U, Pearson's Chi-square test and Fischer's exact Chi-square test were used for statistical analyses. Results: One hundred forty-five cases completed follow up. Thirty-nine cases (Group A) were associated with extracardiac lethal defects and the pregnancies were terminated; these cases were excluded from statistical evaluation. Twenty parents in Group B3 opted also for termination. The survival rates of ongoing pregnancies after 18 months of follow-up between the three cardiac abnormality Groups (Group B1, n=37; Group B2, n=12; and Group B3, n=37) were 89.2%, 66.7%, and...

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Section: Discussionsupporting

confidence: 77%

Counseling and outcomes of antenatally diagnosed congenital heart anomalies in Turkey

Gedikbaşı¹,

Öztarhan²,

Yıldırım³

et al. 2011

Anadolu Kardiyol Derg

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“…La incidencia de alteraciones cromosómicas en los casos fallecidos del grupo B fue del 29%; en otras series, osciló entre el 28% y el 66%. [3][4][5][6][12][13][14][15] Coincidimos con la mayoría de los grupos en que las anomalías asociadas a CC con mayor frecuencia son las del SNC; en nuestra serie, fue más frecuente la agenesia del cuerpo calloso, pero en otros estudios la anencefalia, la hidrocefalia …”

Section: Discussionunclassified

Mortalidad fetal y neonatal en pacientes con cardiopatías congénitas aisladas y asociadas a anomalías extracardíacas

Marantz¹

2013

Arch Argent Pediat

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“…Fasnacht MS [2] reported that the most common genetic disorders of these fetuses were: trisomy 13, 21 and 18, and micro deletion 22q11 Sy. Boldt T. [3] reported in his study that artificial abortion had an incidence of 35% and that 8% died in uterus. The frequency of genetic disorders was 28%.…”

Section: Discussionmentioning

confidence: 99%

Congenital fetal heart disease — course and outcome of pregnancies

Plešinac¹,

Plecas²,

Ljubić³

et al. 2007

Open Medicine

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AbstractThe aim of the study was to analyze the course and outcome of pregnancies with congenital heart disease of the fetus, diagnosed and terminated at the Institute of gynecology and obstetrics Clinical Center of Serbia over four years.The study included 71 patients, divided into 3 groups according to the fetal outcome. Group 1 had consisted of 9 pregnancies terminated artificially, Group 2 of 48 patients who delivered live fetuses, and Group 3 of 14 pregnancies terminated as fetal intrauterine death.The types congenital heart diseases were categorized as follows: 40 had L-R shunting type, 18 R-L shunting type, 8 coartacion of aorta, and 7 valvular diseases. Intrauterine fetal death occurred in 11 pregnancies in Group 3 after 28 weeks of gestation. In 13 cases karyotypisation were done, because of maternal age or intrauterine growth retardation diagnosed with ultrasound, and 9 of them had genetic disorders. Forty-eight fetuses were born alive. Fourteen died in the first 2–7 days and 12 had successful heart surgery. Twenty-two needed no surgical correction. Ultrasound findings were false negative in 3 cases.The diagnosis of fetal heart disease should be done by fetal echocardiogram, which can be preformed early in the beginning of the pregnancy.

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Outcome of Structural Heart Disease Diagnosed In Utero

Abstract: Our data indicate that despite elective, planned delivery the prognosis for fetuses with in utero diagnosed heart defect was poor. The outcome was largely attributable to associated extracardiac malformations and chromosomal abnormalities.

Cited by 53 publications

References 17 publications

Counseling and outcomes of antenatally diagnosed congenital heart anomalies in Turkey

Counseling and outcomes of antenatally diagnosed congenital heart anomalies in Turkey

Mortalidad fetal y neonatal en pacientes con cardiopatías congénitas aisladas y asociadas a anomalías extracardíacas

Congenital fetal heart disease — course and outcome of pregnancies

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