Outcome of Reproductive Age Women With Stage IA or IC Invasive Epithelial Ovarian Cancer Treated With Fertility-Sparing Therapy

Schilder, Jeanne M.; Thompson, Amy; DePriest, Paul D.; Ueland, Frederick R.; Cibull, Michael L.; Modesitt, Susan C.; Lu, Karen H.; Geisler, John P.; Higgins, Robert V.; Magtibay, Paul M.; Cohn, David E.; Powell, Matthew A.; Chu, Christina; Stehman, Frederick B.; Nagell, J. van

doi:10.1097/01.ogx.0000058684.18516.cf

Cited by 54 publications

(85 citation statements)

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“…Among those 10 patients with high-risk ovarian carcinoma, none experienced recurrence. Schilder and colleagues (31) reported that the estimated 5-year and 10-year survivals of patients were 98% and 93%, respectively, which compare favorably to the reported survival rates of patients with stage I ovarian cancer treated by more radical surgery.…”

Section: Discussionsupporting

confidence: 56%

“…However, the salvage rate of patients who recurred, and the longterm disease-free survival in those patients who did not undergo completion surgery, suggests that expectant management is a viable option as well, particularly in case of borderline ovarian tumors. The young age at diagnosis places these patients in a higher risk group, and genetic testing can be offered to clearly define individual risk (31).…”

Section: Discussionmentioning

confidence: 99%

“…For invasive early ovarian cancer, some reports have demonstrated that well selected patients can safely benefit from conservative treatment as well, if platinum-based adjuvant chemotherapy is administered when indicated (clear cell histotype, grading 2-3, FIGO stage more than Ia) (2,(28)(29)(30)(31). In addition, germ cell tumors are highly chemosensitive and occur in young women in whom fertility-sparing surgery should always be pursued.…”

mentioning

confidence: 98%

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Laparoscopic fertility-sparing staging in unexpected early stage ovarian malignancies

Muzii

Palaia

Sansone

et al. 2009

Fertility and Sterility

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

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Laparoscopic fertility-sparing staging in unexpected early stage ovarian malignancies

Muzii

Palaia

Sansone

et al. 2009

Fertility and Sterility

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“…A multi-institutional retrospective investigation of 52 patients with Stage IA or 1C disease reported that 50 patients were alive without evidence of disease at a median of 68 months of follow-up. Two died of disease at 13 and 97 months after initial treatment [26]. A review of the European experience revealed relapse was seen in 11% (10 of 88) of patients with stage 1A disease and 10% (5 of 51) patients with stage 1C disease [27].…”

Section: Fertility Sparingmentioning

confidence: 98%

Quality-of-Life Issues in the Management of Epithelial Ovarian Cancer

Lowe

Ferrell

Leong

2007

Curr. Treat. Options in Oncol.

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The importance of quality-of-life (QOL) measurements in cancer management is being increasingly appreciated. This is especially important in patients with advanced cancers. Over 80% of women with epithelial ovarian cancer (EOC) will present with disease outside the ovary as there are no accurate screening tests, and symptoms usually do not develop until EOC has spread. Standard treatment includes debulking surgery followed by chemotherapy to which most women will have a complete response but only a minority of women with advanced disease will be cured. Fortunately, advances in surgical and chemotherapeutic management have improved overall survival with 45% of women of all stages living 5 years or longer. EOC may in many cases be considered a "chronic cancer," which highlights the importance of QOL in management decisions. QOL may be affected by the disease itself as well as by surgical and chemotherapeutic treatments. Future studies of the care and treatment of EOC patients should include well-designed QOL evaluations.

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“…Fertility preservation appears to be safe in selected young women with disease grossly confined to one ovary; this approach spares the uterus and normal contralateral ovary [8]. The other procedures necessary for comprehensive staging should still be performed.…”

Section: Introductionmentioning

confidence: 96%

Operative management of primary epithelial ovarian cancer

Leitao

Dennis

2007

Curr Oncol Rep

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Surgery plays an integral part in the primary management of early-stage and advanced-stage epithelial ovarian cancer. Surgical staging is essential for disease grossly confined to the ovaries or pelvis. Comprehensive surgical staging often results in upstaging of patients who were presumed to be at an early stage. Accurate staging has an impact on prognosis and treatment strategies. Optimal surgical cytoreduction leads to improved outcomes in patients with advanced disease; before initiation of chemotherapy, it offers the most favorable outcome and should be offered to all patients. Intraperitoneal catheters for postoperative chemotherapy instillation may be offered and placed at the time of cytoreduction. Neoadjuvant chemotherapy and interval cytoreduction are a possibility for patients who are not amenable to an optimal cytoreduction based on preoperative findings or in those who are at extremely high risk for surgery.

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Outcome of Reproductive Age Women With Stage IA or IC Invasive Epithelial Ovarian Cancer Treated With Fertility-Sparing Therapy

Cited by 54 publications

References 0 publications

Laparoscopic fertility-sparing staging in unexpected early stage ovarian malignancies

Laparoscopic fertility-sparing staging in unexpected early stage ovarian malignancies

Quality-of-Life Issues in the Management of Epithelial Ovarian Cancer

Operative management of primary epithelial ovarian cancer

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