Outcome of Repeat Pulmonary Metastasectomy

Krüger, M.; Franzke, K.; Rajab, Taufiek Konrad; Nadler, Fabian; Möbius-Winkler, Moritz; Zinne, Norman; Schulz, Daniel; Möller, Miriam; Schütte, Wolfgang; Ermitsch, Michael; Redwan, Bassam; Schega, O; Biancosino, Christian

doi:10.1007/5584_2021_635

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Several studies have investigated the benefits of repeated metastasectomy. We could however demonstrate in our own substantial collective that even repeat lung metastasectomy show a survival benefit provided that a close multidisciplinary evaluation has taken place ( 9 ). In this regard it has to be taken into consideration that possibly anatomical resections in the first place could limit the possibility of repeat metastasectomies.…”

Section: Impact Of the Extent Of Lung Resectionmentioning

confidence: 99%

Pulmonary metastasectomy—is the extent of resection worth reconsidering?

Krüger¹,

Biancosino²

2022

J Thorac Dis

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Section: Impact Of the Extent Of Lung Resectionmentioning

confidence: 99%

Pulmonary metastasectomy—is the extent of resection worth reconsidering?

Krüger¹,

Biancosino²

2022

J Thorac Dis

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Pulmonary Metastasectomy

Eisenberg

Deboever

Antonoff

2023

Thoracic Surgery Clinics

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Pulmonary metastasectomy and repeat metastasectomy for colorectal pulmonary metastases: outcomes from the Dutch Lung Cancer Audit for Surgery

Dorp¹,

Wolfhagen

Torensma

et al. 2023

BJS Open

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Background Surgical resection of recurrent pulmonary metastases in patients with colorectal cancer is an established treatment option; however, the evidence for repeat resection is limited. The aim of this study was to analyse long-term outcomes from the Dutch Lung Cancer Audit for Surgery. Methods Data from the mandatory Dutch Lung Cancer Audit for Surgery were used to analyse all patients after metastasectomy or repeat metastasectomy for colorectal pulmonary metastases from January 2012 to December 2019 in the Netherlands. Kaplan–Meier survival analysis was performed to determine the difference in survival. Multivariable Cox regression analyses were performed to identify predictors of survival. Results A total of 1237 patients met the inclusion criteria, of which 127 patients underwent repeat metastasectomy. Five-year overall survival was 53 per cent after pulmonary metastasectomy for colorectal pulmonary metastases and 52 per cent after repeat metastasectomy (P = 0.852). The median follow-up was 42 (range 0–285) months. More patients experienced postoperative complications after repeat metastasectomy compared with the first metastasectomy (18.1 per cent versus 11.6 per cent respectively; P = 0.033). Eastern Cooperative Oncology Group performance status greater than or equal to 1 (HR 1.33, 95 per cent c.i. 1.08 to 1.65; P = 0.008), multiple metastases (HR 1.30, 95 per cent c.i. 1.01 to 1.67; P = 0.038), and bilateral metastases (HR 1.50, 95 per cent c.i. 1.01 to 2.22; P = 0.045) were prognostic factors on multivariable analysis for pulmonary metastasectomy. Diffusing capacity of the lungs for carbon monoxide less than 80 per cent (HR 1.04, 95 per cent c.i. 1.01 to 1.06; P = 0.004) was the only prognostic factor on multivariable analysis for repeat metastasectomy. Conclusion This study demonstrates that patients with colorectal pulmonary metastases have comparable median and 5-year overall survival rates after primary or recurrent pulmonary metastasectomy. However, repeat metastasectomy has a higher risk of postoperative complications.

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Outcome of Repeat Pulmonary Metastasectomy

Cited by 3 publications

References 17 publications

Pulmonary metastasectomy—is the extent of resection worth reconsidering?

Pulmonary metastasectomy—is the extent of resection worth reconsidering?

Pulmonary Metastasectomy

Pulmonary metastasectomy and repeat metastasectomy for colorectal pulmonary metastases: outcomes from the Dutch Lung Cancer Audit for Surgery

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