Outcome of pregnancy in sickle cell anemia and sickle cell-hemoglobin C disease

Milner, Paul F.; Jones, Bennie R.; Döbler, Johanna

doi:10.1016/0002-9378(80)90241-0

Cited by 58 publications

(19 citation statements)

References 17 publications

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“…Spontaneous abortion rates were 19 -24% in recent reports, 11 an exception being the 5.9% rate from the Cooperative Study, 2 which will have been affected by the 29.4% rate of elective abortions. Even within previous Jamaican studies, abortion rates have varied from 9.4% to 13.3%, 3,12,13 figures that did not differ from estimates in the normal population.…”

Section: Discussionmentioning

confidence: 84%

Outcome of Pregnancy in Homozygous Sickle Cell Disease

Serjeant¹,

Loy²,

Crowther³

et al. 2004

Obstetrics & Gynecology

164

128

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Section: Discussionmentioning

confidence: 84%

Outcome of Pregnancy in Homozygous Sickle Cell Disease

Serjeant¹,

Loy²,

Crowther³

et al. 2004

Obstetrics & Gynecology

164

128

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“…So hospital‐based observations may have selected mildly affected cases of SS disease and provided larger pregnant SC groups among whom problems could develop. The impression of a severe outcome in SC disease was also derived from reports in the United States; a review of literature 23 from 1956 to 1973 found 581 pregnancies in 201 SC subjects with a maternal mortality of 2.2 per 100 pregnancies and significant morbidity especially in some series 2,7,24,25 . Selection of mildly affected cases of SS disease may also have exaggerated the relative severity in SC disease in the United States, prompting Curtis 7 to comment that although fewer women with SS disease became pregnant, those who did so had milder courses than women with SC disease.…”

Section: Discussionmentioning

confidence: 99%

Fecundity and pregnancy outcome in a cohort with sickle cell‐haemoglobin C disease followed from birth

Serjeant¹,

Hambleton²,

Thame

2005

BJOG

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Objective To compare pregnancy outcome in sickle cell‐haemoglobin C (SC) disease with that in homozygous sickle cell (SS) disease and age‐matched controls with a normal haemoglobin (AA) genotype. Design A cohort study followed from birth. Setting Sickle Cell Clinic, University Hospital and other Jamaican hospitals. Population Ninety‐five pregnancies in 43 patients with SC disease, 94 pregnancies in 52 patients with SS disease and 157 pregnancies in 68 controls. Methods Systematic review of all pregnancies occurring in sample population. Kaplan–Meier analysis for interval to first pregnancy, and the t test, χ2 test or Fisher's exact test as appropriate; correction was made for multiple testing and multiple linear regression was used for analysis of determinants of birthweight. Main outcome measures Age at menarche, interval to first pregnancy, outcome of pregnancy, maternal complications and possible predictors of low birthweight. Results Menarche was marginally delayed in SC disease compared with AA controls (median age 13.7 vs 13.0 years, P= 0.02) but age at first pregnancy was similar (median age 22.5 vs 20.1 years, P= 0.32). Pregnancy outcome in SC disease did not differ from AA controls but compared with SS disease there were marginally fewer miscarriages, more live deliveries and greater birthweight. The prevalence of pregnancy‐induced hypertension, pre‐eclampsia, antepartum or postpartum haemorrhage in SC disease did not differ from AA controls but the prevalence of sickle‐related complications was similar to SS disease. Conclusions Contrary to some claims, pregnancy outcome in SC disease is generally benign compared with SS disease.

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“…There were almost an equal number of stillbirths and early neonatal deaths. Milner et al (1980) have reported a similar frequency but with 80% of the deaths being intrauterine and only 20% neonatal deaths.…”

Section: Discussionmentioning

confidence: 70%

Pregnancy in sickle cell disease in Bahrain

El-Shafei

Dhaliwal

Sandhu

1992

BJOG

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Objective To review the maternal and fetal complications in pregnant women with sickle cell disease and to compare their pregnancy outcome with those of controls. Design A case‐control study. Setting Ministry of Health hospitals in Bahrain. Subjects 147 pregnancies in 140 women with sickle cell disease and 294 controls matched for age and parity Main outcome measures The characteristics of women who had crises, the frequency of the crises, hypertensive disorders of pregnancy, infection, diabetes, perinatal mortality and the delivery statisties in the index and control women. Results Maternal mortality was 1.4% and perinatal mortality was 73.3/1000 total births in women with sickle cell disease, there were no maternal deaths and the perinatal mortality was 6.8/1000 births in the control group. Anaemia was treated by blood transfusion in 47% of women with sickle cell disease and, of these, 39% had a crisis that appeared to have been precipitated by the transfusion in the absence of any other predisposing factors. The presence of raised HbF did not decrease the number of crises but reduced their severity. Conclusion Pregnancy in women with sickle cell disease should be monitored very closely as it constitutes a high risk to both the mother and the baby.

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Outcome of pregnancy in sickle cell anemia and sickle cell-hemoglobin C disease

Cited by 58 publications

References 17 publications

Outcome of Pregnancy in Homozygous Sickle Cell Disease

Outcome of Pregnancy in Homozygous Sickle Cell Disease

Fecundity and pregnancy outcome in a cohort with sickle cell‐haemoglobin C disease followed from birth

Pregnancy in sickle cell disease in Bahrain

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