Outcome of pregnancy in mothers given bromocriptine.

Griffith, R.W.; Turkalj, Ivan; Braun, P.

doi:10.1111/j.1365-2125.1978.tb01629.x

Cited by 79 publications

(16 citation statements)

References 11 publications

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“…Because bromocriptine is usually stopped as soon as pregnancy is diagnosed, data about the effects of bromocriptine on PRL secretion during pregnancy are scanty (13). We found only one report of the use of bromocriptine throughout pregnancy when an acromegalic woman was given 10 mg bromocriptine daily (14).…”

Section: Discussionmentioning

confidence: 95%

Does Bromocriptine Block Thyrotropin-Releasing Hormone-Induced Prolactin Release during Pregnancy?*

Ylikorkala¹,

Kivinen²,

Rönnberg³

et al. 1980

The Journal of Clinical Endocrinology & Metabolism

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PRL responses to 200 microgram of iv TRH were measured in 16 healthy women with normal early pregnancy before and at the endo of bromocriptine treatment of 5.0--7.5 mg daily for 1--2 weeks. Before the start of bromocriptine, TRH caused a PRL elevation from 19.1 +/- 2.2 to 95.2 +/- 12.6 ng/ml (mean +/- SE) after 20 min, with a mean maximal PRL increment of 71.7 +/- 11.6 ng/ml. Bromocriptine suppressed basal plasma PRL level to 3.6 +/- 0.8 ng/ml (P less than 0.001). TRH then caused a PRL rise to 18.8 +/- 1.8 ng/ml at 20 min, with a mean maximal PRL increment of 15.7 +/- 1.8 ng/ml. The absolute PRL response was significantly smaller (P less than 0.001) during bromocriptine intake than before, whereas the mean percent increments in PRL levels after TRH administration were similar in the presence and absence of bromocriptine. Fifteen of these women were restudied with TRH stimulation 4--6 weeks after legal abortion, and the PRL responses to TRH were normal. When 7 of these women were once again treated with bromocriptine and retested with TRH, no absolute or relative PRL response to TRH emerged. These results release differs between the pregnant and nonpregnant states.

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Section: Discussionmentioning

confidence: 95%

Does Bromocriptine Block Thyrotropin-Releasing Hormone-Induced Prolactin Release during Pregnancy?*

Ylikorkala¹,

Kivinen²,

Rönnberg³

et al. 1980

The Journal of Clinical Endocrinology & Metabolism

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“…The incidence of abortions, ectopic pregnancies, or congenital malformations is similar in bromocriptine-using mothers and the general population (136,(146)(147)(148)(149). One undescended testis and one talipes deformity were reported with the use of bromocriptine throughout gestation (147).…”

Section: Prolactinomas and Pregnancymentioning

confidence: 87%

Pregnancy and pituitary disorders

Karaca¹,

Tanrıverdi²,

Ünlühızarcı³

et al. 2010

European Journal of Endocrinology

156

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Major hormonal changes emerge during pregnancy. The pituitary gland is one of the most affected organs with altered anatomy and physiology. The pituitary gland is enlarged as a result of lactotroph hyperplasia. Due to physiological changes in the pituitary and target hormone levels, binding globulins, and placental hormones, hormonal evaluation becomes more complex in pregnant women. As a consequence of physiological hormonal changes, the evaluation of pituitary functions in pregnant women is quite different from that done in the prepregnant state. Pituitary adenomas may cause problems by their hormone secretion that affects the mother and the fetus besides causing an increased risk of tumor growth. Furthermore, diagnosis, course, and treatment of pituitary diseases point out differences. The changes in anatomy and physiology of the pituitary gland during pregnancy are reviewed. Pituitary disorders namely Cushing's disease; acromegaly; prolactinoma; TSH-secreting, gonadotropin-producing, and clinically nonfunctioning adenomas; craniopharyngioma; and Sheehan's syndrome, which is one of the most common causes of hypopituitarism, lymphocytic hypophysitis, and hypopituitarism, in relation to pregnancy are discussed. Being aware of all this information will prevent any serious problems which mother and child will be exposed to.

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“…Because bromocriptine treatment is usually stop¬ ped as soon as pregnancy is diagnosed, data about the effects of bromocriptine on Prl secretion dur¬ ing pregnancy are scanty (Griffith et al 1978). In one report, Prl levels were not suppressed when an acromegalic woman was given 10 mg of bromocrip¬ tine daily throughout pregnancy (Bigazzi et al 1979).…”

Section: Discussionmentioning

confidence: 98%

Bromocriptine treatment during early human pregnancy: effect on the levels of prolactin, sex steroids and placental lactogen

Ylikorkala

Kivinen

Rönnberg

1980

Acta Endocrinologica

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To elucidate the role of prolactin (Prl) in the endocrinology of early human pregnancy, 28 healthy women were given 5.0\p=n-\7.5 mg of bromocriptine daily for two weeks between weeks 6\p=n-\9 of normal gestation. Plasma Prl, oestradiol-17\g=b\(Oe2), progesterone (P), testosterone (T) and human placental lactogen (hPL) were measured before, and one and two weeks after the start of bromocriptine, and they were compared with those in 22 control women who were followed similarly but without bromocriptine treatment. Bromocriptine treatment induced a significant Prl depression at one week (7.3 \ m=+-\ 4.3 ng/ml vs 23.7 \m=+-\11.4 ng/ml) and two weeks (5.3 \m=+-\2.5 ng/ml vs 31.9 \m=+-\ 16.4 ng/ml). Oe2, P. T and hPL levels, however, showed no significant differences between the groups. Two women undergoing bromocriptine treatment (7.1%) and one control woman (4.5%) experienced spontaneous incomplete abortion during the study period, but these three already had a low Oe2 level and a low/or undetectable hPL level at the beginning of the study. It is obvious that neither maternal 'hypoprolactinaemia' nor bromocriptine during early human pregnancy interfere with the normal progress of pregnancy or with the normal synthesis of sex steroids and hPL at this time. A certain amount of prolactin (Prl) is necessary for progesterone production by human granulosa cells in tissue culture; however, both subnormal and high local Prl concentrations have an inhibitory effect (McNatty et al. 1974). This phenomenon has also been confirmed in vivo, since both hyperprolactinaemia (Friesen et al. 1973) and bromocriptine-induced hypoprolactinaemia (Schulz et al. 1976. 1978; Bohnet et al. 1977) led to deficient luteal function or anovulation in non-pregnant women. Prl may also be involved with the secretion of androgens (Carter et al. 1977;Rubin et al. 1977;Bassi et al. 1977;Kandeel et al. 1978). During human pregnancy, the level of Prl exceeds the non-pregnant level after 32 -36 days from con¬ ception (Barberia et al. 1975), yet it is not known whether this Prl rise is crucial for the normal progress of earlv pregnancy and for the normal production of sex steroids and peptide hormones. The present study was therefore designed to deter¬ mine the effects of bromocriptine on the plasma levels of prolactin, oestradiol, progesterone, testos¬ terone and human placental lactogen during early human pregnancy. Materials and MethodsFifty healthy women admitted for legal abortion between weeks 6 -9 of gestation volunteered for this study after being fully informed about its purpose and course ( Table I). The pregnancies were uncomplicated, with the uter¬ ine sizes comparable with the duration of amenorrhoea. Twenty-eight women were given bromocriptine (Parlodel®. Sandoz Ltd., Basel, Switzerland) orallv at a dose of 5 to 7.5 mg dailv for two weeks, and 22 women served as controls. After the study period of two weeks, all women underwent an uncomplicated abortion with va¬ cuum currettage (n = 47) or with hysterotomy (n = 3). Venous blood samples were col...

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Outcome of pregnancy in mothers given bromocriptine.

Cited by 79 publications

References 11 publications

Does Bromocriptine Block Thyrotropin-Releasing Hormone-Induced Prolactin Release during Pregnancy?*

Does Bromocriptine Block Thyrotropin-Releasing Hormone-Induced Prolactin Release during Pregnancy?*

Pregnancy and pituitary disorders

Bromocriptine treatment during early human pregnancy: effect on the levels of prolactin, sex steroids and placental lactogen

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