Outcome of Pregnancies Among Sickle Cell Patients Admitted to Cotonou University Hospitals (Benin) from 2008 to 2018

Patrice, Dangbemey; Tognifode, Veronique; Azonbakin, Simon; Nicole, Tchiakpe-Enialoko; Aboubakar, Moufalilou; Ogoudjobi, Mathieu; Symphorose, Lokossou; Venance, Nzikou; Tshabu-Aguemon, Christiane; Benjamin, Hounkpatin; Josiane, Tonato-Bagnan; Lewis, Denakpo

doi:10.11648/j.jgo.20200806.11

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Anemia was closely followed by vaso-occlusive crisis in form of bone pain with a frequency of 77.8%. This is much higher than that obtained in Port Hacourt (50%) and Jos (51.4%), Benin(23.8%) and Ibadan (7.3%) [11,21,25,27] Similar studies in Africa and outside Africa also recorded lower values than that discovered in our study centre -Benin Republic (19.5%), Cameroon (50%), USA (50%)24,19.and Baharain (65.3%) [28,24,19,29]. There was a low incidence of malaria in pregnancy (22.2%) observed in this study.…”

Section: Discussioncontrasting

confidence: 65%

Pregnancy Outcomes in Women with Sickle Cell Disease (SCD): A Tertiary Centre Retrospective Study in Nigeria

Lovelyn,

Florence,

Chima

et al. 2023

JAMMR

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Background: Sickle cell disease is the most common inherited condition. Due to recent advances in medical care for patients with sickle cell anaemia, more women with SCD are able to survive up to the reproductive age group. This has given rise to a higher number of pregnant women with SCD. It results in increased fetal and maternal risks due to the metabolic demands, hypercoagulable state and vascular stasis often associated with pregnancy. It has therefore become imperative to explore what progress has been made over the last decade as well as what can be done to achieve the best outcome in these women. Methods: This was a retrospective study of women with SCD who accessed antenatal care (ANC) at the Nnamdi Azikiwe University Teaching Hospital (NAUTH) Nnewi over a ten year period. Folder numbers were obtained from the obstetrics clinic and thereafter the folders were assessed and data retrieved using a checklist. Data analysis was done using SPSS 24. Results: The prevalence of sickle cell disease among pregnant women in this centre was 0.03%. All the women had the HbSS variants. The mean age of the subjects was 28.3 ± 5.6years. Majority of the women were gainfully employed. The mean gestational age at booking was 26 9.5 weeks. Half of the neonates had fetal distress at birth. Commonest maternal complication was anemia (100%) followed by vaso-occlusive crisis (89%). Eighty nine percent of the women were delivered by emergency caesarean section prior to 37 weeks gestational age. Preterm birth and fetal distress were the commonest neonatal complications. Conclusion: The study revealed that pregnancy associated with sickle cell disease still carries high maternal and fetal morbidity in this environment. Majority of the women with SCD in pregnancy did not receive preconception care and also did not commence their ANC early enough. There is need to educate women with SCD on the need for preconception care to ensure optimization of health prior to conception. They should also book early enough to facilitate close fetal monitoring throughout pregnancy.

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Section: Discussioncontrasting

confidence: 65%

Pregnancy Outcomes in Women with Sickle Cell Disease (SCD): A Tertiary Centre Retrospective Study in Nigeria

Lovelyn,

Florence,

Chima

et al. 2023

JAMMR

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Acute pain episodes, acute chest syndrome, and pulmonary thromboembolism in pregnancy

et al. 2022

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Pregnancy in women with sickle cell disease (SCD) is a life-threatening condition. In both high- and low-income countries, there is an 11-fold increased risk of maternal death and a 4-fold increased risk of perinatal death. We highlight the epidemiology of SCD-specific and obstetric complications commonly seen during pregnancy in SCD and propose definitions for acute pain and acute chest syndrome (ACS) episodes during pregnancy. We conducted a systematic review of the recent obstetric and hematology literature using full research articles published within the last 5 years that reported outcomes in pregnant women with SCD. The prevalence of acute pain episodes during pregnancy ranged between 4% and 75%. The prevalence of ACS episodes during pregnancy ranged between 4% and 13%. The estimated prevalence of pulmonary thromboembolism in women with SCD during pregnancy is approximately 0.5 to 1%. ACS is the most common cause of death and is often preceded by acute pain episodes. The most crucial time to develop these complications in pregnancy is during the third trimester and postpartum period. In a pooled analysis from studies in low- and middle-income settings, maternal death in women with SCD is approximately 2393 and 4300 deaths per 100 000 live births with and without multidisciplinary care, respectively. In comparison, in the US and northern Europe, the general maternal mortality rate is approximately 23.8 and 8 deaths per 100 000 live births, respectively. A multidisciplinary SCD obstetrics care approach reduces maternal and perinatal morbidity and mortality in low- and middle-income countries.

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Outcome of Pregnancies Among Sickle Cell Patients Admitted to Cotonou University Hospitals (Benin) from 2008 to 2018

Cited by 2 publications

References 14 publications

Pregnancy Outcomes in Women with Sickle Cell Disease (SCD): A Tertiary Centre Retrospective Study in Nigeria

Pregnancy Outcomes in Women with Sickle Cell Disease (SCD): A Tertiary Centre Retrospective Study in Nigeria

Acute pain episodes, acute chest syndrome, and pulmonary thromboembolism in pregnancy

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