Outcome of pleurodesis using different agents in management of malignant pleural effusion

Elkolaly, Reham M.; Aboelnasr, Mohamed Sabry; El-Guindy, Dina M.

doi:10.1016/j.ejcdt.2015.12.017

Cited by 8 publications

(11 citation statements)

References 21 publications

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“…The study by El-Kolaly et al [23] concluded that povidone-iodine resulted in complete pleurodesis in 73.3% of cases. Godazandeh et al [41] were in line with the present results and found that povidone-iodine resulted in complete pleurodesis in 72.2% of patients and partial pleurodesis in 19.4% of patients with 91.6% overall success rate.…”

Section: Discussionmentioning

confidence: 99%

“…Malignant pleural effusion is a frequent complication observed in patients with advanced stages of malignancies that usually requires drainage to relieve patients' symptoms [30,31]. Pleurodesis aims to prevent re-accumulation of fluid to improve patients' quality of life [23]. TUS is a sensitive method capable of detecting an amount of pleural fluid ≤50 ml and can assure adherence of the parietal and visceral pleurae [13].…”

Section: Discussionmentioning

confidence: 99%

“…The mixture was instilled to pleural cavity via the thoracoscope, and then, the intercostal tube was inserted. A tube clamp was applied for 2 h during which, the patient was asked to rotate to right and left lateral positions every 15 min and then the clamp was released [15,[23][24][25].…”

Section: Group 2 (Pleurodesis With Tetracycline Solution)mentioning

confidence: 99%

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Transthoracic sonographic scores in evaluating the success of different scelerosing modalities in patients with malignant pleural effusion

et al. 2022

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Background Malignant pleural effusions (MPE) mostly arises from metastases to the pleura from other sites. Management of malignant effusions aims to palliate dyspnea and prevent the reaccumulation of pleural fluid to improve patients’ quality of life. Pleurodesis is the most common palliative treatment for patients with refractory MPE. This study was carried out to evaluate the performance of transthoracic sonographic (TUS) scores (pleural sliding and pleural adherence score) in predicting the success of pleurodesis by different modalities in patients with malignant pleural effusion. One hundred malignant pleural effusion patients were enrolled to an interventional clinical trial from September 2019 to April 2021 for palliative management of dyspnea. Pleurodesis for palliative treatment of dyspnea was done either spontaneously by the intercostal chest tube or by a sclerosing agent such as tetracycline solution or tetracycline poudrage or iodopovidine. Patients were randomly allocated to one of these four groups where each group included 25 patients. Transthoracic ultrasound was performed at baseline, and 1 month after pleurodesis and the lung sliding score and pleural adherence score were evaluated. Results Majority of patients (78%) had high baseline lung sliding score (7-8). Post pleurodesis only 11.4% had high scores (p<0.001), also the mean lung sliding score decreased significantly in comparison to the baseline values (p˂ 0.001) in the spontaneous, tetracycline solution, tetracycline poudrage, and iodopovidine groups (7.04 ± 1.02 vs. 4.85 ± 1.60, 7.28± 0.98 vs. 4.48± 1.75, 7.20±0.96 vs. 4.44 ± 1.45, 7.04±0.93 vs. 3.35±1.81, respectively). Iodopovidine pleurodesis group in comparison to the other modalities showed the highest pleural adherence score (12.64 ± 2.98) and absent lung sliding in 72.7% of cases and 70 % success rate. Pleural adherence score at cut off ≥ 12 showed 92.75% sensitivity, 89.47% specificity, 92.1 accuracy, and 0.911 area under the curve (AUC) for predicting successful pleurodesis. Conclusion TUS scores is a feasible, bedside, and accurate method to detect the outcome of pleurodesis. Iodopovidone was more effective than tetracycline solution, tetracycline poudrage, and spontaneous pleurodesis. Trial registration ClinicalTrials.gov. NCT04074902. Registered on 29 August 2019

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Transthoracic sonographic scores in evaluating the success of different scelerosing modalities in patients with malignant pleural effusion

et al. 2022

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“…That was consistent with Saleh et al, 2020, who reviewed 104 patients of malignant pleural effusion, who were treated palliatively in their cardiothoracic surgery department at Mansoura University Hospital in 2020, and their mean ages were 57.55 ± 9.02 years [13]. El-Kolaly et al, 2016, found that 28 (62.22%) of the 45 patients with recurrent malignant pleural effusion were female, compared to 17 out of 45 patients (37.78%) who were male [14].…”

Section: Discussionmentioning

confidence: 99%

Use of chest ultrasonography to compare two methods of pleurodesis (autologous blood versus doxycycline)

Fattah

Halfawy²,

Elessawy³

et al. 2023

Fayoum University Medical Journal

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Pleurodesis is the application of substance into the pleura to cause adherence to parietal and visceral pleura and obliteration of the potential space between them. This is mostly indicated for MPE or recurrent pneumothorax [1].Unless the patient has a trapped lung or a short life expectancy pleurodesis is a better option for recurrent malignant pleural effusion, than thoracocentesis [2,3]. By using chest ultrasound, it is possible to find

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“…Pleural effusion results from the accumulation of abnormal fluid in the pleural cavity, caused by several conditions, including congestive heart failure, pneumonia, and malignancy (El-Kolaly et al, 2016). Pleural effusion can be an early sign of lung cancer in more than 25% of cases.…”

Section: Introductionmentioning

confidence: 99%

The Relationship of Amount of Pleural Fluid and Time of Pleurodesis with the Results of Pleurodesis in Malignant Pleural Effusions

Sutanto,

Sigit,

Kurniawan

2020

INDONES J MED

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Background: Pleural effusion can be an early sign of lung cancer in more than 25% of cases. Lung cancer is the most common cause of malignant pleural effusion (MPE). Pleurodesis is performed when the amount of pleural fluid is <150 ml/day, but it is difficult as its productive nature. This study aimed to find the right time to perform pleurodesis on patients with MPE, which is expected to achieve optimal results. Subjects and Method: This was a cross-sectional study conducted at Dr. Moewardi Hospital, Surakarta, Central Java, from June to July 2020. The study subjects were 17 patients with malignant pleural effusion (MPE) diagnosed with lung cancer who underwent water seal drainage (WSD) and indicated for pleurodesis. The dependent variable was the success of the pleurodesis procedure. The independent variables were the amount of evacuated pleural fluid and the time of pleurodesis performed. The study instruments were diagnosis of lung cancer with anatomic pathology, measurement of the amount of pleural fluid, and posteroanterior chest X-ray evaluating the success of pleurodesis. The data were analyzed using Spearman correlation, ANOVA to determine the differences in the amount of pleural fluid at the first, second, and third hours, and continued with post hoc LSD analysis using SPSS 21. Results: The pleurodesis success rate had positive correlation with the amount of pleural fluid (r= 0.24; p= 0.345) and the time of pleurodesis performed at the first hour (r= 0.10; p= 0.701), second hour (r= 0.03; p= 0.921), and third hour (r= 0.41; p= 0.106). Pleurodesis performed at the second hour had the lowest amount of pleural fluid (Mean= 84.66; SD= 38.88), followed by third hour (Mean= 110.77; SD= 65.57), and first hour (Mean= 111.22; SD= 57.83), but the differences were not statistically significant (p= 0.285). Conclusion:The pleurodesis success rate has a positive correlation with the amount of pleural fluid and the time of pleurodesis, but it was not statistically significant. There is no significant difference in the amount of pleural fluid evacuated at the three different times of pleurodesis. The least amount of pleural fluid obtains at the second hour (14.00-22.00).

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Outcome of pleurodesis using different agents in management of malignant pleural effusion

Cited by 8 publications

References 21 publications

Transthoracic sonographic scores in evaluating the success of different scelerosing modalities in patients with malignant pleural effusion

Transthoracic sonographic scores in evaluating the success of different scelerosing modalities in patients with malignant pleural effusion

Use of chest ultrasonography to compare two methods of pleurodesis (autologous blood versus doxycycline)

The Relationship of Amount of Pleural Fluid and Time of Pleurodesis with the Results of Pleurodesis in Malignant Pleural Effusions

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