Outcome of Periapical Lesions in a Rat Model of Type 2 Diabetes: Refractoriness to Systemic Antioxidant Therapy

Wolle, Carlos Frederico Brilhante; Zollmann, Luciana A.; Bairros, Patrícia O.; Etges, Adriana; Leite, Carlos Eduardo; Morrone, Fernanda Bueno; Campos, Maria M.

doi:10.1016/j.joen.2012.12.030

Cited by 21 publications

(25 citation statements)

References 41 publications

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“…In contrast to the findings with ALA, Wolle et al . () reported that, another antioxidant agent tempol, failed to improve the outcome of endodontic lesions in type 2 diabetic rats. However, in this study no antioxidant‐treated control group was used.…”

Section: Discussionmentioning

confidence: 98%

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Effects of alpha‐lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro‐CT analysis

Aksoy¹,

Savtekin

Şehirli

et al. 2019

Int Endodontic J

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Aim To investigate the possible therapeutic effects of alpha‐lipoic acid (ALA) in a model of chronic apical periodontitis in rats by analysing biochemical, histopathological and micro‐CT parameters. Methodology The study was approved by the Animal Ethics Committee of the Near East University. Thirty‐two Wistar rats were divided into four groups of eight rats each: Control Group; ALA Group; AP Group; AP + ALA Group. In the AP and AP + ALA groups, the pulp chambers of the mandibular first molars were surgically exposed and were left open to the oral environment for 4‐weeks to allow the establishment of periapical lesions. The rats in the Control and AP groups were treated intraperitoneally with saline solution (with a daily dose of 100 mg kg−1, for 28 days after periapical lesion induction). The rats in the ALA and AP + ALA groups were treated intraperitoneally with ALA (with a daily dose of 100 mg kg−1, for 28 days after periapical lesion induction). After decapitation, the trunk blood was collected for the assessment of biochemical parameters. The mandibles were surgically removed and dissected for histopathologic analysis and further scanned with micro‐CT. Groups of data were compared with a two‐way analysis of variance (two‐way anova) followed by Sidak's multiple comparison tests. Values of P < 0.05 were regarded as significant. Results TNF‐α, IL‐1β, MMP‐1, MMP‐2 levels were significantly lower in AP + ALA group compared with AP group (P < 0.05). There was a significant difference between the AP and AP + ALA groups according to assessment of the inflammatory scores (P < 0.05). The periapical inflammatory infiltrates were significantly more severe (P < 0.05) in the AP group. The AP + ALA group exhibited lower values both in terms of surface area and volume of resorption cavities than the AP group and this difference was significant (P < 0.05). Conclusion alpha‐lipoic acid treatment provided therapeutic effects on the inhibition of periapical bone loss.

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Section: Discussionmentioning

confidence: 98%

“…However, limited information is available on adjuvant antioxidant therapy in apical periodontitis. Wolle et al (2013) assessed the potential actions of the antioxidant agent tempol by evaluating the development of apical periodontitis in rat models of type 2 diabetes and cardiomyopathy in two studies (Wolle et al 2012(Wolle et al , 2013.…”

Section: Discussionmentioning

confidence: 99%

Effects of alpha‐lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro‐CT analysis

Aksoy¹,

Savtekin

Şehirli

et al. 2019

Int Endodontic J

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“…Wolle et al . () evaluated the development of PLs in a rat model of type 2 diabetes and assessed the potential actions of the antioxidant agent tempol. Neither radiographic nor histologic analysis revealed any significant difference between controls and type 2 diabetic rats.…”

Section: Association Between Endodontics and Diabetes Mellitusmentioning

confidence: 99%

“…Liu et al (2012) reported that metformin, one of the antihyperglycaemic agents commonly used for the treatment of type 2 diabetes, decreases periapical bone loss area after pulp exposure in Wistar rats through lowering the RANKL/osteoprotegerin (OPG) ratio, reducing the number of osteoclasts and bone resorption areas. Wolle et al (2013) evaluated the development of PLs in a rat model of type 2 diabetes and assessed the potential actions of the antioxidant agent tempol. Neither radiographic nor histologic analysis revealed any significant difference between controls and type 2 diabetic rats.…”

Section: Diabetes Mellitus and Apical Periodontitis: Animal Studiesmentioning

confidence: 99%

Endodontic medicine: connections between apical periodontitis and systemic diseases

2015

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The prevalence of apical periodontitis (AP) in Europe has been reported to affect 61% of individuals and 14% of teeth, and increase with age. Likewise, the prevalence of root canal treatment (RCT) in Europe is estimated to be around 30-50% of individuals and 2-9% of teeth with radiographic evidence of chronic persistent AP in 30-65% of root filled teeth (RFT). AP is not only a local phenomenon and for some time the medical and dental scientific community have analysed the possible connection between apical periodontits and systemic health. Endodontic medicine has developed, with increasing numbers of reports describing the association between periapical inflammation and systemic diseases. The results of studies carried out both in animal models and humans are not conclusive, but suggest an association between endodontic variables, that is AP and RCT, and diabetes mellitus (DM), tobacco smoking, coronary heart disease and other systemic diseases. Several studies have reported a higher prevalence of periapical lesions, delayed periapical repair, greater size of osteolityc lesions, greater likelihood of asymptomatic infections and poorer prognosis for RFT in diabetic patients. On the other hand, recent studies have found that a poorer periapical status correlates with higher HbA1c levels and poor glycaemic control in type 2 diabetic patients. However, there is no scientific evidence supporting a causal effect of periapical inflammation on diabetes metabolic control. The possible association between smoking habits and endodontic infection has also been investigated, with controversial results. The aim of this paper was to review the literature on the association between endodontic variables and systemic health (especially DM and smoking habits).

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“…A Diabetes Mellitus é uma doença sistêmica crônica que engloba sistemas metabólicos, vasculares e endócrinos, provavelmente de caráter hereditário, consequente à deficiência parcial ou total de insulina, o que acarreta uma inadequada utilização dos carboidratos e alterações no metabolismo lipídico e proteico (1)(2)(3)(4)(5) . Essa alteração sistêmica resulta em uma profunda ou absoluta deficiência de produção de insulina -tipo I, dependentes de insulinoterapia diária (correspondendo a 5-10% dos casos), ou resistência do tecido aos seus efeitos metabólicos celulares -tipo II, não insulino dependente, o que ocorre em 90% dos casos, nos quais o paciente faz o controle de sua glicemia apenas com dietas, sendo a insulina utilizada em casos excepcionais (5)(6)(7) .…”

Section: Introductionunclassified

Prevalência de lesão endodôntica em pacientes diabéticos

Ferreira¹,

Gomes²,

Uchoa³

2014

RBPS

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Outcome of Periapical Lesions in a Rat Model of Type 2 Diabetes: Refractoriness to Systemic Antioxidant Therapy

Cited by 21 publications

References 41 publications

Effects of alpha‐lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro‐CT analysis

Effects of alpha‐lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro‐CT analysis

Endodontic medicine: connections between apical periodontitis and systemic diseases

Prevalência de lesão endodôntica em pacientes diabéticos

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