Outcome of patients with injection drug use–associated endocarditis admitted to an intensive care unit

Saydain, Ghulam; Singh, Jatinder; Dalal, Bhavinkumar; Yoo, Wonsuk; Levine, Donald P.

doi:10.1016/j.jcrc.2009.09.007

Cited by 31 publications

(17 citation statements)

References 17 publications

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“…Wreszcie, rozpoznanie IZW może stanowić problem, a u części pacjentów zostaje ustalone dopiero pośmiertnie [413]. Mimo postępów w diagnostyce i leczeniu śmiertelność pozostaje szczególnie wysoka u osób w krytycznym stanie, wynosząc 29-84% [411,414,415]. Ocena liczby pacjentów wymagających przyjęcia na OIT z powodu IZW stanowi problem.…”

Section: Profilaktykaunclassified

“…Chociaż może wystąpić u pacjentów z wszczepionym układem stymulującym serce, ICD, centralnym wkłuciem żylnym lub CHD, najczęściej dotyczy osób uzależnio-nych od dożylnych narkotyków, szczególnie pacjentów ze współistniejącym zakażeniem ludzkim wirusem niedoboru odporności (HIV) lub pacjentów leczonych immunosupresyjnie [420][421][422]. Dominującym czynnikiem etiologicznym zakażenia jest S. aureus (60-90% przypadków) [419,423], z narastającą częstością występowania szczepów metycylinoopornych [414]. Wzrasta również częstość zakażeń wieloma rodzajami drobnoustrojów [424].…”

Section: Infekcyjne Zapalenie Wsierdziaunclassified

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2015 ESC Guidelines for the management of infective endocarditis

Habib¹,

Lancellotti

Antunes³

et al. 2015

Kardiol Pol

129

211

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Section: Profilaktykaunclassified

Section: Infekcyjne Zapalenie Wsierdziaunclassified

2015 ESC Guidelines for the management of infective endocarditis

Habib¹,

Lancellotti

Antunes³

et al. 2015

Kardiol Pol

129

211

View full text Add to dashboard Cite

“…Infective endocarditis is an increasingly common consequence of injection drug use that requires hospitalization for intravenous antibiotics, and in severe cases, cardiac surgery to replace the infected valves [18–20]. Infective endocarditis may be complicated by septic embolization to the lungs, central nervous system, spleen, and other organs [21,22]. These complications can lead to lengthy hospital stays and are associated with a significant mortality risk.…”

Section: Introductionmentioning

confidence: 99%

A Cost Analysis of Hospitalizations for Infections Related to Injection Drug Use at a County Safety-Net Hospital in Miami, Florida

et al. 2015

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BackgroundInfections related to injection drug use are common. Harm reduction strategies such as syringe exchange programs and skin care clinics aim to prevent these infections in injection drug users (IDUs). Syringe exchange programs are currently prohibited by law in Florida. The goal of this study was to estimate the mortality and cost of injection drug use-related bacterial infections over a 12-month period to the county safety-net hospital in Miami, Florida. Additionally, the prevalence of HIV and hepatitis C virus among this cohort of hospitalized IDUs was estimated.Methods and FindingsIDUs discharged from Jackson Memorial Hospital were identified using the International Classification of Diseases, Ninth Revision, codes for illicit drug abuse and endocarditis, bacteremia or sepsis, osteomyelitis and skin and soft tissue infections (SSTIs). 349 IDUs were identified for chart abstraction and 92% were either uninsured or had publicly funded insurance. SSTIs, the most common infection, were reported in 64% of IDUs. HIV seroprevalence was 17%. Seventeen patients (4.9%) died during their hospitalization. The total cost for treatment for injection drug use-related infections to Jackson Memorial Hospital over the 12-month period was $11.4 million.ConclusionsInjection drug use-related bacterial infections represent a significant morbidity for IDUs in Miami-Dade County and a substantial financial cost to the county hospital. Strategies aimed at reducing risk of infections associated with injection drug use could decrease morbidity and the cost associated with these common, yet preventable infections.

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“…Aureus, Acinetobacilis baumani, Strept.pneumonie). This fact is seen in 15% of cases [15]. Urinalysis may show evidence of gross or microscopic hematuria, proteinuria, or pyuria.…”

Section: Discussionmentioning

confidence: 98%

Infective Endocarditis Related to Intravenous Drug User: Report of Four Cases

Muco¹,

Harxhi²,

Hasa³

et al. 2018

TOIDJ

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Objective:To describe the clinical, laboratory, microbiological, and echocardiographic findings in four intravenous drug users with endocarditis hospitalized and followed in our Infectious Disease Service, a tertiary university hospital as well as to determine the efficacy of medical treatment. Methods:From a database of 35 subjects with endocarditis during five years, we made a retrospective analysis of data for four cases between the age of 24-33 years old which were intravenous drug users. Results:Infective endocarditis was encountered in four drug users with positive blood cultures (Staphylococcus aureus was present in all the cases), vegetations in the tricuspid native valve in ultrasound, high fever (more than 38 o C). The four cases were male and the mean age was 29 years (range 24-33 years). Three out of the four cases presented with pulmonary involvement and only one with femoral and popliteal vein thrombosis. Two out of four cases had acute renal and hepatic failure and only one had acute cutaneous vasculitis. Transesophageal Echocardiography (TEE) was also performed in two cases. For all of them medical management consisted of antibiotic therapy and two out of them underwent surgery because of the persistence of valvular vegetations after antibiotic therapy. The prognosis was good with 0% mortality. Conclusion:Infective endocarditis should be considered in the differential diagnosis of intravenous drug users presenting with various clinical scenarios. Echocardiography remains the main modality and should be used serially to facilitate early diagnosis. The successful management of a complicated case often requires the close cooperation of an infectious disease physician, a cardiologist, an addiction physician and occasionally a cardiac surgeon.

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Outcome of patients with injection drug use–associated endocarditis admitted to an intensive care unit

Cited by 31 publications

References 17 publications

2015 ESC Guidelines for the management of infective endocarditis

2015 ESC Guidelines for the management of infective endocarditis

A Cost Analysis of Hospitalizations for Infections Related to Injection Drug Use at a County Safety-Net Hospital in Miami, Florida

Infective Endocarditis Related to Intravenous Drug User: Report of Four Cases

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