Outcome of Patients with Diabetic Ketoacidosis in South of Iran

Ilkhanipoor, Homa

doi:10.15226/2374-6890/4/2/00177

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…The recovery time was delayed by 76% (AHR=0.24, 95% CI=0. 16 Adult DKA patients with ≥97hrs of duration DKA till treatment had slower recovery as compared with those who had ≤24hrs (AHR=0.46, 95%CI 0.33-0.64).…”

Section: Predictors Of Recovery Time From Dkamentioning

confidence: 88%

“…DKA patients with appropriate treatment are expected to make a full recovery within 24 hours (9, 11, 14, 15). Prolonged recovery of DKA leads to hypoglycemia and hypokalemia (9), renal failure, coma, cerebral edema, cardiac arrhythmia(16, 17), lung edema with respiratory failure, and thromboembolic complications(18), and leads to death (19, 20).…”

Section: Introductionmentioning

confidence: 99%

“…Timely diagnosis and initiation of management of DKA is associated with the recovery and prevents hypoglycemia and hypokalemia (9); renal failure, coma, cerebral edema, and cardiac arrhythmia (16, 18), hyperchloremia metabolic acidosis, hypophosphatemia, and thromboembolic complications (18). This in turn decrease bed occupancy in the hospital, length of hospital stay and reduce the amount of human and material resource needed to control it as well as its complications.…”

Section: Introductionmentioning

confidence: 99%

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Time to Recovery from Diabetic Ketoacidosis and its Predictors among Adult Diabetic Ketoacidosis Patients in DEBRE MARKOS Referral Hospital, North West Ethiopia, 2021: Retrospective Cohort Study

Temesgen

Miskir

Dessie

et al. 2022

Preprint

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Introduction : Diabetic ketoacidosis is an acute life-threatening complication of diabetes mellitus. With appropriate treatments, diabetic ketoacidosis patients are expected to make a full recovery within 24 hours. Previous studies did not address variables such as duration of diabetic ketoacidosis symptoms, and blood glucose level. In addition, the recovery time and its predictors of diabetic ketoacidosis in adult patients are not well known in Ethiopia. Objective : To assess time to recovery from diabetic ketoacidosis and its predictors among adult diabetic ketoacidosis patients in Debre Markos referral hospital, North West Ethiopia, 2021 Methods: A retrospective cohort study was employed among 452 records of adult diabetic ketoacidosis patients who were admitted starting from January 1, 2016 to January 1, 2021 using their medical registration number. Data were entered into Epi-data version 4.6 and analyzed using Stata version 14. A Kaplan Meier survival curve was used to estimate diabetic ketoacidosis-free survival time. In addition, a generalized log-rank test was utilized to compare diabetic ketoacidosis-free survival time between different categorical explanatory variables. Cox proportional hazards model was used to identify predictors of time to diabetic ketoacidosis recovery time. Variables with a P-value < 0.25 in the bivariable analysis were entered into a multivariable Cox proportional hazards model to identify predictors of recovery time at p<= 0.05. Result: The median time to recovery from diabetic ketoacidosis for all observations was 24 hours. Severity of diabetic ketoacidosis (AHR=0.24, 95%CI=0.16-0.35), duration of diabetic ketoacidosis (AHR=0.46, 95%CI 0.33-0.64), diabetes duration (AHR=1.74, 95%CI 1.35-2.25), and random blood sugar level (AHR=0.64, 95%CI= (0.51-0.79) were significant predictors of recovery time. Conclusion and recommendation: The median time to recovery from diabetic ketoacidosis was relatively prolonged. The hospital shall give special attention to patients with the identified predictors. Further study using a prospective design by including admission pH and admission serum potassium level is advised.

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Section: Predictors Of Recovery Time From Dkamentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Time to Recovery from Diabetic Ketoacidosis and its Predictors among Adult Diabetic Ketoacidosis Patients in DEBRE MARKOS Referral Hospital, North West Ethiopia, 2021: Retrospective Cohort Study

Temesgen

Miskir

Dessie

et al. 2022

Preprint

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Incidence and predictors of mortality in children with diabetic ketoacidosis in the comprehensive specialized referral hospitals of West Amhara Region, Northwest Ethiopia: a retrospective follow-up study

Shimelash,

Belay,

Aknaw

et al. 2023

Front. Clin. Diabetes Healthc.

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BackgroundDiabetic ketoacidosis is one of the major life-threatening conditions associated with acute metabolic complications. It remains a major public health problem in developing countries such as Ethiopia.ObjectiveTo assess the incidence and prediction of mortality in children with diabetic ketoacidosis in West Amhara Region Comprehensive Specialized Referral Hospitals, Northwest Ethiopia, in 2022.MethodsAn institution-based retrospective follow-up study was conducted among 423 study participants with a confirmed diagnosis of diabetic ketoacidosis from 01/01/2017 to 31/12/2021. Data were entered, coded, cleaned, and checked using Epi-Data version 4.6 and exported to Stata version 14 for data analysis.ResultsA total of 401 child records were included in the final analysis and were followed for 3781 days during the study period. The overall mortality of children with diabetic ketoacidosis was 10.6 per 1000 person-days observed (95% CI: 7.8-14.4) during the entire follow-up period. Hypoglycemia (AHR=4.6; 95% CI: 2.13-10.1), rural residence (AHR=2.9; 95% CI=1.01-8.11), age younger than five (AHR=4.4; 95% CI=1.4-13.7) or between five and 10 (AHR=3.1; 95% CI=1.1-8.8), and female gender (AHR=2.6; 95% CI=1.1-5.8) were significant predictors of mortality.ConclusionsThe incidence rate of mortality in children with diabetic ketoacidosis was relatively high. Age, rural residence, female gender, and hypoglycemia were significantly predictive of mortality. Community education or mass campaigns about the signs and symptoms of diabetic ketoacidosis may reduce the mortality rate in children.

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Outcome of Patients with Diabetic Ketoacidosis in South of Iran

Abstract: Introduction: Diabetic Keto acidosis (DKA) is the most common cause of mortality in children with diabetes mellitus. The aim of this study is to investigate the complications of DKA and its complications in hospitalized patients in Namazi hospital, Shiraz, Iran.

Cited by 2 publications

References 18 publications

Time to Recovery from Diabetic Ketoacidosis and its Predictors among Adult Diabetic Ketoacidosis Patients in DEBRE MARKOS Referral Hospital, North West Ethiopia, 2021: Retrospective Cohort Study

Time to Recovery from Diabetic Ketoacidosis and its Predictors among Adult Diabetic Ketoacidosis Patients in DEBRE MARKOS Referral Hospital, North West Ethiopia, 2021: Retrospective Cohort Study

Incidence and predictors of mortality in children with diabetic ketoacidosis in the comprehensive specialized referral hospitals of West Amhara Region, Northwest Ethiopia: a retrospective follow-up study

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