Outcome of patients with diabetes and unstable angina. A subgroup analysis in the Spanish Multicentre Trial of trifusal in unstable angina

Garcı́a-Rubira, Juan C.; Cruz, Jurandir Ferreira da; López, Víctor; Plaza, L; Navas, José Casals

doi:10.1016/0167-5273(94)90040-x

Cited by 9 publications

(3 citation statements)

References 7 publications

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“…Our data confirm also the negative influence on ACS patients' outcome of high serum creatinine [29][30][31][32], glucose levels [33][34][35][36] and low hemoglobin concentration at admission [37][38][39], suggesting that an accurate assessment of comorbidities is very important for ACS patients' care, especially when an early invasive strategy is preferred.…”

Section: Discussionsupporting

confidence: 70%

Early invasive strategy and outcomes of non-ST-elevation acute coronary syndrome patients: is time really the major determinant?

et al. 2011

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In non-ST-elevation acute coronary syndromes (ACS), an early invasive strategy is recommended for middle/high-risk patients; however, the optimal timing for coronary angiography is still debated. The aim of this study was to evaluate the prognostic implications of the time of angiography in ACS patients treated in accord with an early invasive strategy. We analyzed the relationship between the time of angiography and outcomes at followup in 517 ACS patients, of whom 482 were revascularized with percutaneous coronary intervention (PCI) (86.9%) or coronary artery by-pass graft (13.1%). We also evaluated the influence of clinical, biohumoral and angiographic variables on the patients' outcomes at follow-up. Among patients submitted to angiography at different time intervals from both hospital admission and symptom onset, significant differences neither in mortality nor in cardiac ischemic events at follow-up were observed. At univariate analysis, complete versus partial revascularization, longer hospital stay, higher TIMI risk score, diabetes mellitus, higher discharge creatinine and admission anemia were associated with mortality and cardiac ischemic events at follow-up; a lower left ventricular ejection fraction was associated with mortality; higher peak troponin I and previous PCI were associated with cardiac ischemic events at follow-up. At multivariate analysis longer hospital stay, higher discharge creatinine levels, and previous PCI were independent predictors of cardiac ischemic events at follow-up. Our evaluation in ACS patients treated with an early invasive strategy does not support the concept that angiography should be performed as soon as possible after symptom onset or hospital admission. Rather, an unfavorable long-term outcome is influenced principally by the clinical complexity of patients.

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Section: Discussionsupporting

confidence: 70%

Early invasive strategy and outcomes of non-ST-elevation acute coronary syndrome patients: is time really the major determinant?

et al. 2011

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“…Women receive ASA less frequently than do men, but patients with UA/NSTEMI of either 776,779,780 and diabetes is an important independent predictor for adverse outcomes (death, MI, or readmission with UA at 1 year; RR 4.9). [781][782][783][784] In addition, many patients with diabetes who present with UA/NSTEMI have already undergone CABG. 785 Patients with diabetes tend to have more extensive noncoronary vascular comorbidities, hypertension, LV hypertrophy, cardiomyopathy, and HF.…”

Section: Discussionmentioning

confidence: 99%

2011 ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction

Anderson¹,

Adams²,

Antman³

et al. 2011

Circulation

674

363

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“…697,839,[885][886][887][888] Patients with UA/NSTEMI and diabetes have more severe CAD, 886,889,890 and diabetes is an important independent predictor for adverse outcomes (death, MI, or readmission with UA at 1 year; RR 4.9). [891][892][893][894] In addition, many patients with diabetes who present with UA/NSTEMI have already undergone CABG. 895 Patients with diabetes tend to have more extensive noncoronary vascular comorbidities, hypertension, LV hypertrophy, cardiomyopathy, and HF.…”

Section: Discussionmentioning

confidence: 99%

2012 ACCF/AHA Focused Update Incorporated Into the ACCF/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction

Anderson¹,

Adams²,

Antman³

et al. 2013

Circulation

202

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Outcome of patients with diabetes and unstable angina. A subgroup analysis in the Spanish Multicentre Trial of trifusal in unstable angina

Cited by 9 publications

References 7 publications

Early invasive strategy and outcomes of non-ST-elevation acute coronary syndrome patients: is time really the major determinant?

Early invasive strategy and outcomes of non-ST-elevation acute coronary syndrome patients: is time really the major determinant?

2011 ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction

2012 ACCF/AHA Focused Update Incorporated Into the ACCF/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction

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