Outcome of patients with de novo versus nevus-associated melanoma

Lin, William M.; Luo, Su; Muzikansky, Alona; Lobo, Alice Z.C.; Tanabe, Kenneth K.; Sober, Arthur J.; Cosimi, A. Benedict; Tsao, Hensin; Duncan, Lyn M.

doi:10.1016/j.jaad.2014.09.028

Cited by 80 publications

(94 citation statements)

References 26 publications

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“…With regard to the incidence of nevus-associated melanomas in each subtype, the results of this study were consistent with previous findings [6, 12, 23]. It has been proposed that histologic subtype seems to be the primary factor in whether a melanoma is nevus-associated or de novo, with SSMs more likely to emerge in a nevus than other types of melanomas [6, 12]. In patients under 65 years of age, non-ALMs were significantly associated with a higher percentage of nevus-associated melanomas.…”

Section: Discussionsupporting

confidence: 93%

“…Although over half of all melanomas in Asians are ALMs, ALMs account for only 3–10% of all melanoma patients among Caucasians [19–22]. With regard to the incidence of nevus-associated melanomas in each subtype, the results of this study were consistent with previous findings [6, 12, 23]. It has been proposed that histologic subtype seems to be the primary factor in whether a melanoma is nevus-associated or de novo, with SSMs more likely to emerge in a nevus than other types of melanomas [6, 12].…”

Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 75%

“…Melanomas have usually been described in terms of their association with melanocytic nevi [2, 6, 13]. One meta-analysis study for a given time period showed that 32% of melanomas presented in association with a nevus histopathologically [6].…”

Section: Discussionmentioning

confidence: 99%

“…One meta-analysis study for a given time period showed that 32% of melanomas presented in association with a nevus histopathologically [6]. In the current report, only 17.5% of the patients were found to have melanomas with nevi, a rate which was much lower than that reported by a previous study of Caucasian patients [6]. This can be explained by the fact that over 70% of the melanomas of the patients included in this study were ALMs, which are seldom associated with a nevus [2].…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological features and prognosis of patients with de novo versus nevus-associated melanoma in Taiwan

et al. 2017

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Studies surveying melanomas associated with melanocytic nevi in Asia are rare. In this study, we examined whether nevus-associated melanomas differ from de novo melanomas in terms of their associations with clinical factors, histologic characteristics, and patient survival in Taiwan. Using data on cancer cases obtained from the Department of Pathology archives and the Cancer Registry of National Taiwan University Hospital, we conducted a retrospective analysis of 103 consecutive melanoma patients who were diagnosed between 2010 and 2015 and received follow-up through November 2016. Approximately 17.5% of the melanomas in question were associated with a nevus. In patients under 65 years of age, non-acral lentiginous melanomas were significantly associated with a higher percentage of nevus-associated melanomas. The superficial spreading subtype, younger patient age, thinner tumor, intermittent solar exposure, and early stage were significant predictors of a melanoma being histologically associated with a nevus. The appearance of a nevus associated with a melanoma predicted better recurrence-free survival compared with de novo melanomas. Although acral lentiginous melanomas (70.9%) constituted the most common histologic subtype, only 9.6% of the acral lentiginous melanomas were associated with a nevus. Furthermore, there was no statistically significant difference between the nevus-associated and de novo acral lentiginous melanomas with regard to clinicopathological factors and survival. In conclusion, nevus-associated melanomas were uncommon among acral lentiginous melanomas. Relatedly, because over half of all melanomas in Asians are acral lentiginous melanomas, Asians are less likely than Caucasians to have nevus-associated melanomas.

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