Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device: Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA)

Ammirati, Enrico; Brambatti, Michela; Braun, Öscar; Shah, Palak; Cipriani, Manlio; Bui, Quan M; Veenis, Jesse F.; Lee, Euyhyun; Xu, Ronghui; Hong, Kimberly N.; Heyning, Caroline M. Van De; Perna, Enrico; Timmermans, Philippe; Čikeš, Maja; Brugts, Jasper J.; Veronese, Giacomo; Minto, J.; Smith, S C; Gjesdal, Grunde; Gernhofer, Yan K.; Partida, Cynthia; Potena, Luciano; Masetti, M.; Boschi, Silvia Regina Matos da Silva; Loforte, Antonio; Jakuš, Nina; Miličić, Davor; Nilsson, Johan; Bock, Dina De; Sterken, Caroline; Bossche, Klaartje Van den; Rega, Filip; Tran, Hao; Singh, Ramesh; Montomoli, Jonathan; Mondino, Michele; Greenberg, Barry; Russo, Claudio; Pretorius, Victor; Klein, Liviu; Frigerio, Maria; Adler, Eric

doi:10.1016/j.ijcard.2020.09.026

“…Despite multiple obstacles to unequivocal detection of myocardial inflammation, it has been long known that myocardial inflammation [3][4][5][6][7][8][9][10][11][12] occurs in association with multiple types of 'genetic' [13][14][15][16][17][18] and 'non-genetic' [19,20] cardiomyopathies. The possible therapeutic potential of immunomodulation has been addressed in this context [21][22][23], but this issue remains unsolved so far.…”

Section: Novel Insights Into the Role Of Inflammation In Human Cardio...mentioning

confidence: 99%

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Poller¹,

Heidecker²,

Ammirati³

et al. 2022

Preprint

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During the past few years unexpected developments have driven studies in the field of clinical immunology. One driver of immense impact was the outbreak of a pandemic caused by the novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects of immunological re-search into cardiovascular diseases. Here, we specifically focus on selected studies taking ad-vantage of advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics and chemogenetics. First, we discuss emerging clinical relevance of advanced diagnostics for cardiovascular diseases - includ-ing those associated with COVID-19 - with a focus on the role of inflammation in cardiomyopa-thies and arrhythmias. Second, we consider newly identified immunological interactions at or-gan and systems level which affect cardiovascular pathogenesis. Thus, studies into immune in-fluences arising from the intestinal system are moving towards therapeutic exploitation. Fur-ther, powerful new research tools have enabled novel insight into brain – immune system inter-actions at unprecedented resolution. This latter line of investigation emphasizes the strength of influence of emotional stress - acting through defined brain regions - upon viral and cardiovas-cular disorders. Several challenges need to be overcome before the full impact of these far-reaching new findings will hit the clinical arena.

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“…Despite multiple obstacles to unequivocal detection of myocardial inflammation, it has been long known that myocardial inflammation [3][4][5][6][7][8][9][10][11][12] occurs in association with multiple types of 'genetic' [13][14][15][16][17] and 'non-genetic' [18,19] cardiomyopathies. Fig.…”

Section: Novel Insights Into the Role Of Inflammation In Human Cardio...mentioning

confidence: 99%

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Poller¹,

Heidecker²,

Ammirati³

et al. 2022

Preprint

0

View full text Add to dashboard Cite

During the past few years unexpected developments have driven studies in the field of clinical immunology. One driver of immense impact was the outbreak of a pandemic caused by the novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects of immunological re-search into cardiovascular diseases. Here, we specifically focus on selected studies taking ad-vantage of advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics and chemogenetics. First, we discuss emerging clinical relevance of advanced diagnostics for cardiovascular diseases - includ-ing those associated with COVID-19 - with a focus on the role of inflammation in cardiomyopa-thies and arrhythmias. Second, we consider newly identified immunological interactions at or-gan and systems level which affect cardiovascular pathogenesis. Thus, studies into immune in-fluences arising from the intestinal system are moving towards therapeutic exploitation. Fur-ther, powerful new research tools have enabled novel insight into brain – immune system inter-actions at unprecedented resolution. This latter line of investigation emphasizes the strength of influence of emotional stress - acting through defined brain regions - upon viral and cardiovas-cular disorders. Several challenges need to be overcome before the full impact of these far-reaching new findings will hit the clinical arena.

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“…The methods and main findings from the registry have been described previously. 11 Briefly, patients in seven European (EU) hospitals and 3 United States elevated CVP including clinical findings of peripheral edema, presence of ascites or palpable hepatomegaly, or worsening hepatic (total bilirubin > 2.0 mg/dl) or renal dysfunction (creatinine > 2.0 mg/dl). Furthermore, RVF was stratified based on occurrence into early (index hospitalization) and late.…”

Section: Study Populationmentioning

confidence: 99%

Cardiovascular implantable electronic device therapy in patients with left ventricular assist devices: insights from TRAViATA

Darden

¹

,

Ammirati

²

,

Brambatti

³

et al. 2021

International Journal of Cardiology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device: Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA)

Cited by 10 publications

References 19 publications

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Cardiovascular implantable electronic device therapy in patients with left ventricular assist devices: insights from TRAViATA

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