Outcome of Noncatheter-Related Thrombosis in Children: Influence of Underlying or Coexisting Factors

Gürgey, Aytemiz; Aslan, Deniz

doi:10.1097/00043426-200103000-00007

Cited by 56 publications

(40 citation statements)

References 20 publications

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“…A flow chart of search results and their distribution by category of publication is provided in Figure 1, showing both included [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] and excluded reports. Nineteen original reports met eligibility criteria (Table 1); no systematic reviews were identified.…”

Section: Overall Search Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors

Goldenberg¹,

Donadini²,

Kahn³

et al. 2010

Haematologica

172

149

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BackgroundPost-thrombotic syndrome is a manifestation of chronic venous insufficiency following deep venous thrombosis. This systematic review was conducted to critically evaluate pediatric evidence on frequency of occurrence, validity of outcome measures, and prognostic indicators of post-thrombotic syndrome. Design and MethodsA comprehensive literature search of original reports revealed 19 eligible studies, totaling 977 patients with upper/lower extremity deep venous thrombosis. Calculated weighted mean frequency of post-thrombotic syndrome was 26% (95% confidence interval: 23-28%) overall, and differed significantly by prospective/non-prospective analysis and use/non-use of a standardized outcome measure. ResultsStandardized post-thrombotic syndrome outcome measures included an adaptation of the Villalta scale, the Clinical-Etiologic-Anatomic-Pathologic classification, and the Manco-Johnson instrument. Data on validity were reported only for the Manco-Johnson instrument. No publications on post-thrombotic syndrome-related quality of life outcomes were identified. Candidate prognostic factors for post-thrombotic syndrome in prospective studies included use/non-use of thrombolysis and plasma levels of factor VIII activity and D-dimer. ConclusionsGiven that affected children must endure chronic sequelae for many decades, it is imperative that future collaborative pediatric prospective cohort studies and trials assess as key objectives and outcomes the incidence, severity, prognostic indicators, and health impact of post-thrombotic syndrome, using validated measures.

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Section: Overall Search Resultsmentioning

confidence: 99%

“…74 Components of each of these outcome measures are summarized in Figure 2. The remaining 11 studies [3][4][5][6][7]9,12,15,17,19,21 did not indicate the use of a standardized outcome measure.…”

Section: Overall Search Resultsmentioning

confidence: 99%

Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors

Goldenberg¹,

Donadini²,

Kahn³

et al. 2010

Haematologica

172

149

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“…However, in the pediatric age group, it is unknown whether thrombus recurrence and other thrombotic outcomes in children are affected by IT; thus, it remains controversial whether children with thrombosis or offspring in thrombosis-prone families benefit from screening for IT. [102][103][104][105][106][107][108] The aim of this systematic review and meta-analysis was to determine the impact of IT on VTE onset and recurrence in children as a prerequisite to the evaluation of primary and secondary treatment options through randomized controlled trials.…”

Section: Clinical Perspective P 1382mentioning

confidence: 99%

Impact of Inherited Thrombophilia on Venous Thromboembolism in Children

et al. 2008

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Background-The aim of the present study was to estimate the impact of inherited thrombophilia (IT) on the risk of venous thromboembolism (VTE) onset and recurrence in children by a meta-analysis of published observational studies. Methods and Results-A systematic search of electronic databases (Medline, EMBASE, OVID, Web of Science, The Cochrane Library) for studies published from 1970 to 2007 was conducted using key words in combination as both MeSH terms and text words. Citations were independently screened by 2 authors, and those meeting the inclusion criteria defined a priori were retained. Data on year of publication, study design, country of origin, number of patients/controls, ethnicity, VTE type, and frequency of recurrence were abstracted. Heterogeneity across studies was evaluated, and summary odds ratios and 95% CIs were calculated with both fixed-effects and random-effects models. Thirty-five of 50 studies met inclusion criteria. No significant heterogeneity was discerned across studies. Although Ͼ70% of patients had at least 1 clinical risk factor for VTE, a statistically significant association with VTE onset was demonstrated for each IT trait evaluated (and for combined IT traits), with summary odds ratios ranging from 2.63 (95% CI, 1.61 to 4.29) for the factor II variant to 9.44 (95% CI, 3.34 to 26.66) for antithrombin deficiency. Furthermore, a significant association with recurrent VTE was found for all IT traits except the factor V variant and elevated lipoprotein(a). Conclusions-The present meta-analysis indicates that detection of IT is clinically meaningful in children with, or at risk for, VTE and underscores the importance of pediatric thrombophilia screening programs. (Circulation. 2008;118:1373-1382.)

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“…Combined fibrinolytic and anticoagulation treatment decreases this incidence [11]. Venous Thrombosis related mortality being 1% to 2% [2,9,12].…”

Section: Discussionmentioning

confidence: 99%

Pediatric Idiopathic Venous Thrombosis

Sandlas¹

2014

J Vasc Med Surg

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Outcome of Noncatheter-Related Thrombosis in Children: Influence of Underlying or Coexisting Factors

Cited by 56 publications

References 20 publications

Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors

Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors

Impact of Inherited Thrombophilia on Venous Thromboembolism in Children

Pediatric Idiopathic Venous Thrombosis

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