Outcome of mechanical ventilation for acute respiratory failure in patients with pulmonary fibrosis

Fumeaux, Thierry; Rothmeier, Claudia; Jolliet, Philippe

doi:10.1007/s00134-001-1150-0

Cited by 96 publications

(73 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other retrospective case series have reported a higher mortality rate compared to our results among patients admitted to the ICU with acute exacerbation of IPF. 1,[17][18][19][20] Our data support the results recently reported by Churg et al 21 In their report, 10 of 12 patients (9 with usual interstitial pneumonia, 2 with nonspecific interstitial pneumonia, and 1 with chronic hypersensitivity pneumonitis)survived the acute exacerbation and were discharged with survival times of 1 to 11 months. Pulmonary function tests in our cohort revealed relatively mild to moderate impairment prior to presentation.…”

Section: Discussionsupporting

confidence: 90%

Ventilator Settings and Outcome of Respiratory Failure in Chronic Interstitial Lung Disease

Pérez

Yılmaz

Jenad

et al. 2008

Chest

117

132

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 90%

Ventilator Settings and Outcome of Respiratory Failure in Chronic Interstitial Lung Disease

Pérez

Yılmaz

Jenad

et al. 2008

Chest

117

132

View full text Add to dashboard Cite

show abstract

“…In (17). Acute exacerbations of IPF have been described high mortality in several reports (4,5,7,18 (10).…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effect of Polymyxin B-immobilized Fiber Column (PMX) Hemoperfusion Treatment on Acute Exacerbation of Idiopathic Pulmonary Fibrosis

et al. 2006

View full text Add to dashboard Cite

show abstract

“…9 With a poor prognosis and higher risk of infection associated with invasive ventilation, noninvasive ventilation (NIV) has a potentially beneficial role. [11][12][13][14] Recently, Molina-Molina and co-workers reported no significant benefit of mechanical ventilation on the prognosis of IPF patients with ARF. 15 In addition, factors affecting ICU mortality in this group of patients, and the question of how long the support should be given, remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Why Do Patients With Interstitial Lung Diseases Fail in the ICU? A 2-Center Cohort Study

et al. 2013

View full text Add to dashboard Cite

BACKGROUND: Admitting patients with interstitial lung disease (ILD) to the ICU is controversial, due to their associated high mortality when they require invasive mechanical ventilation. We aimed to determine the risk factors for mortality in ILD patients requiring ICU support due to acute respiratory failure. METHODS: An observational cohort study was performed in 2 chest diseases teaching hospitals. We included all ILD patients with acute respiratory failure admitted between 2008 and 2010. Subject demographics, noninvasive ventilation (NIV) and invasive ventilation use, and mortality were obtained from medical records. Subjects receiving NIV were divided based on their continuous or non-continuous demand for NIV. NIV failure was defined as intubation for invasive ventilation, or death during NIV. Cox regression analysis was used to determine the hazard ratio for NIV failure. RESULTS: We enrolled 120 subjects: 71 male, median age 66 years. The types of ILD were idiopathic pulmonary fibrosis (n ‫؍‬ 96), collagen vascular disease (n ‫؍‬ 10), silicosis (n ‫؍‬ 9), drug induced (n ‫؍‬ 3), and eosinophilic pneumonia (n ‫؍‬ 2). The median (IQR) Acute Physiology and Chronic Health Evaluation (APACHE II) score was 24 (19 -31), and 75 (62.5%) subjects received NIV on ICU admission, 47 (62.7%) of whom needed continuous NIV. The NIV failure rate was 49.3% (n ‫؍‬ 37). The mortality rates of continuous NIV, non-continuous NIV, invasive ventilation, and total ICU were 61.7% (29/47), 10.7% (3/28), 89.7% (61/68), 60% (72/120), respectively. APACHE II > 20 and continuous NIV demand indicated significant risk for NIV failure: hazard ratio 2.77 (95% CI 1.19 -6.45), P < .02, and 5.12, (1.44 -18.19), P < .01, respectively. CONCLUSIONS: Because of higher mortality, physicians should consider invasive ventilation cautiously in the ICU management of ILD patients with acute respiratory failure. NIV may be an option in less severely ill patients with APACHE II score < 20.

show abstract

Outcome of mechanical ventilation for acute respiratory failure in patients with pulmonary fibrosis

Abstract: In this study mechanical ventilation for acute respiratory failure in pulmonary fibrosis patients was associated with a 100% mortality, despite aggressive therapeutic and diagnostic procedures.

Cited by 96 publications

References 0 publications

Ventilator Settings and Outcome of Respiratory Failure in Chronic Interstitial Lung Disease

Ventilator Settings and Outcome of Respiratory Failure in Chronic Interstitial Lung Disease

Beneficial Effect of Polymyxin B-immobilized Fiber Column (PMX) Hemoperfusion Treatment on Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Why Do Patients With Interstitial Lung Diseases Fail in the ICU? A 2-Center Cohort Study

Contact Info

Product

Resources

About