Outcome of Magnetic Resonance Imaging (MRI) Technique on Vascular Cognitive Impairment (VCI): Meta-Analysis

Abstract

Background:The significant justification for why vascular cognitive impairment (VCI) happens is because of cerebrovascular disease. If not recognized early, this will prompt vascular dementia. To have the option to analyze VCI the assessment procedure ought to be foremost, in order to assist with effective treatment strategy to forestall extra vascular harm. Objective:The purpose of this meta-analysis is to evaluate the scoring system used to assess VCI after magnetic resonance imaging (MRI) technique.Methods: A PRISMA selection protocol was used to identify neuroimaging studies across electronic database such as PubMed, Google scholar, Embase and web of science from May 13, 2011 to October 10, 2022. A total of 26 studies evaluating neuropsychological assessment such as Educational experience, Mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA), Fazekas perivascular (PV) Score, Hamilton depression rating scale (HAMD), Hamilton anxiety scale (HAMA) and Activities daily living scale(ADL) for VCI after MRI method. Meta-analysis was performed by Rev-Man 5.4. Results:The meta-analysis included 26 MRI studies on VCI patients and control. The studies included a total number of 2,253 individuals, 1,192 were in the control group and 1,061 patients in VCI group. The cognitive function assessed by the meta-analysis revealed VCI with lesser MMSE scores (Heterogeneity: Tau 2 = 6.75; Chi 2 = 879.81, df = 19 (P < 0.00001); I 2 = 98%) and MoCA scores (Heterogeneity: Tau 2 = 12.76; Chi 2 = 736.56, df = 15 (P < 0.00001); I 2 = 98%) respectively. The analysis showed that, educational level is positively related with cognitive function in VCI patients (Heterogeneity: Chi 2 = 39.68, df = 20 (P = 0.005); I 2 = 50%). The control group observed a lesser HAMA and Fazekas PV score compared to VCI. But there was no significant difference for HAMD and ADL between the two groups. Conclusion:Cognitive performance in subjects with VCI can be evaluated using neuropsychological scoring system following MRI technique. Furthermore, MMSE and MoCA scores following education increases positive cognitive function.