Outcome of long gap esophageal atresia at 6 years: A prospective case control cohort study

BOURG, Agate; Gottrand, Frédéric; Parmentier, Benoît; THOMAS, Julie; Lehn, Anne; Piolat, C.; Bonnard, Arnaud; Sfeir, Rony; LIENARD, Julie; Rousseau, Véronique; Pouzac, Myriam; LIARD, Agnès; Buisson, Philippe; HAFFREINGUE, Aurore; DAVID, Louis; BRANCHEREAU, Sophie; CARCAUZON, Véronique; Kalfa, Nicolas; Leclair, Marc-David; Lardy, H.; Irtan, Sabine; VARLET, François; Gelas, Thomas; POTOP, Diana; AUGER-HUNAULT, Marie

doi:10.1016/j.jpedsurg.2022.07.023

Cited by 8 publications

(12 citation statements)

References 64 publications

(71 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 A long initial hospital stay, as well as significant associated anomalies, and persistent digestive or respiratory symptoms may negatively influence on health-related quality of life. [24][25][26] Other studies have also remarked that a prolonged hospital stay may be related to suboptimal longterm morbidity and neurodevelopment outcomes. 27,28 Postoperative complications such as gastroesophageal reflux disease with need for antireflux surgery and anastomotic strictures were similar among analyzed centers.…”

Section: Discussionmentioning

confidence: 99%

Thoracoscopic Stage Internal Traction Repair Reduces Time to Achieve Esophageal Continuity in Long Gap Esophageal Atresia

Borselle,

Davidson,

Loukogeorgakis

et al. 2023

Eur J Pediatr Surg

View full text Add to dashboard Cite

Aim of the study: Management of long gap oesophageal atresia (LGOA) is controversial. This study aims at comparing the management of LGOA between two high-volume centers. Methods: We included patients with LGOA (type A and B) between 2008 and 2022. Demographics, surgical methods and outcomes were collected and compared. Results: The study population involved 28 patients–Centre A and 24 patients–Centre B. A surgical approach was thoracoscopic in the Centre A, only for one patient was open for final procedure. In the Centre B 3 patients were treated only thoracoscopically, 2 converted to open and 19 as open surgery. In the Centre A primary oesophageal anastomosis concerned 1 case, two-staged oesophageal lengthening using external traction-1 patient and 26 were treated with the multi-staged internal traction technique. In 24 patients a full anastomosis was achieved: in 23 patients the internal traction technique solely was used, and 1 patient required open Collis-Nissen procedure as final management. In the Centre B primary anastomosis was performed in 7 patients, delayed oesophageal anastomosis in 8 patients, oesophageal lengthening using external traction in one case and 9 infants required oesophageal replacement with gastric tube. Analysed postoperative complications included: early mortality-2/28 due to accompanied malformations (Centre A) and 0/24 (Centre B); anastomotic leakage-4/26 (Centre A) treated conservatively-all patients had a contrast study and 0/24 (Centre B)-1 case of pleural effusion, but no routine contrast study); recurrent strictures 13/26 (Centre A) and 7/15 (Centre B); need for fundoplication 5/26 (Centre A) and 2/15(Centre B). Age at oesophageal continuity was as a median 31 days in Centre A and 110 days in Centre B. Median time between initial procedure and the oesophageal anastomosis was 11 days in Centre A and 92 days in Centre B Conclusions: Thoracoscopic internal traction technique reduces time to achieve oesophageal continuity and the need for oesophageal substitution while maintaining a similar early complication rate.

show abstract

Section: Discussionmentioning

confidence: 99%

Thoracoscopic Stage Internal Traction Repair Reduces Time to Achieve Esophageal Continuity in Long Gap Esophageal Atresia

Borselle,

Davidson,

Loukogeorgakis

et al. 2023

Eur J Pediatr Surg

View full text Add to dashboard Cite

show abstract

“…These include a high prevalence of GERD (66%-100%), 8,37,106,107 45% rate of esophagitis, 8 13% rate of Barrett's esophagus, 76 a high frequency of ARP (31%-65%), 8,37,106,107 and a high prevalence of AS (57%-79%). 8,37,76,93 These high-risk patients generally receive long-term PPI treatments. 106 However, due to the heterogeneity of treatment in this rare form of EA, almost no data exist on PPI efficacy; a single retrospective study reported GERD symptom improvement in 69% of cases.…”

Section: Lgea and Ppismentioning

confidence: 99%

Section: Lgea and Ppismentioning

confidence: 99%

Proton pump inhibitors in esophageal atresia: A systematic review and meta‐analysis

Dimitrov,

Aumar,

Duhamel

et al. 2024

J. pediatr. gastroenterol. nutr.

Self Cite

View full text Add to dashboard Cite

Gastroesophageal reflux disease (GERD) is frequent and prolonged in esophageal atresia (EA) pediatric patients requiring routine use of proton pump inhibitors (PPIs). However, there are still controversies on the prophylactic use of PPIs and the efficacy of PPIs on GERD and EA complications in this special condition. The aim of the study is to assess the prophylactic use of PPIs in pediatric patients with EA and its complications. We, therefore, performed a systematic review including all reports on the subject from 1980 to 2022. We conducted meta‐analysis of the pooled proportion of PPI—and no PPI groups using random effect model, meta‐regression, and estimate heterogeneity by heterogeneity index I2. Thirty‐eight reports on the topic met the criteria selection, representing a cumulative 6044 patients with EA. Prophylactic PPI prescription during the first year of life does not appear to prevent GERD persistence at follow‐up and is not associated with a significantly reduced rate of antireflux surgical procedures (ARP). PPIs improve peptic esophagitis and induce remission of eosinophilic esophagitis at a rate of 50%. Their effect on other GERD outcomes is uncertain. Evidence suggests that PPIs do not prevent anastomotic stricture, Barrett's esophagus, or respiratory complications. PPI use in EA can improve peptic and eosinophilic esophagitis but is ineffective on the other EA complications. Side effects of PPIs in EA are almost unknown.

show abstract

“…One and six years follow up: A nested cohort is an excellent tool derived from a large database, wherein a specific group of patients is invited to participate in a new study. We recently conducted a review of the long-gap EA subgroup at six years of age, underscoring the importance of digestive morbidity in this subset (12). Additionally, two studies examined the nutritional status of the entire cohort at one year of age and found that 15.2% of patients were undernourished and 19% were stunted at the age of 1 year with no significant catch-up between ages 6 months and 1 year.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…We recently conducted a review of the long-gap EA subgroup at 6 years of age, underscoring the importance of digestive morbidity in this subset. 12 Additionally, two studies examined the nutritional status of the entire cohort at 1 year of age and found that 15.2% of patients were undernourished and 19% were stunted at the age of 1 year with no significant catch-up between ages 6 months and 1 year. Patients born preterm (41%), small for gestational age (17%), or with associated abnormalities (55%) were at higher risk of undernutrition and stunting at age 1 year.…”

Section: Population-based Esophageal Atresia Registry Sfeir Et Almentioning

confidence: 99%

The French Experience with a Population-Based Esophageal Atresia Registry (RENATO)

Sfeir,

Aumar,

Sharma

et al. 2023

Eur J Pediatr Surg

Self Cite

View full text Add to dashboard Cite

In this paper, is presented a national register for esophageal atresia (EA) started in January 2008. We report our experience about the conception of this database and its coordiantion. Data management and data quality are also detailed. In 2023, more then 2500 patients with esophageal atresia are included. Prevalence of EA in France was calculated at 1.8/10000 living birth. Main clinical results are listed with scientifc publications issued directly from the register.

show abstract

Outcome of long gap esophageal atresia at 6 years: A prospective case control cohort study

Cited by 8 publications

References 64 publications

Thoracoscopic Stage Internal Traction Repair Reduces Time to Achieve Esophageal Continuity in Long Gap Esophageal Atresia

Thoracoscopic Stage Internal Traction Repair Reduces Time to Achieve Esophageal Continuity in Long Gap Esophageal Atresia

Proton pump inhibitors in esophageal atresia: A systematic review and meta‐analysis

The French Experience with a Population-Based Esophageal Atresia Registry (RENATO)

Contact Info

Product

Resources

About