2011
DOI: 10.1086/521659
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Outcome ofEscherichia coliand/orKlebsiellaBloodstream Infection in Children With Central Venous Catheters

Abstract: We conducted a retrospective cohort study of children with catheter-associated bloodstream infections (BSIs) due to Escherichia coli and/or Klebsiella. Risk factors for poor outcome (ie, death or recurrence of infection) were receipt of mechanical ventilation (adjusted odds ratio [aOR], 4.6 [95% confidence interval {CI}, 1.39-16.30]) and receipt of total parenteral nutrition (aOR, 3.5 [95% CI, 1.1-10.8]). A significant proportion of children with catheter-associated BSI were treated successfully without cathet… Show more

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Cited by 7 publications
(3 citation statements)
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“…From the 38 potentially eligible studies (see Figure 5), we found one systematic review 43 and eight retrospective cohort studies in children. [45][46][47][48][49][50][51][52] We excluded seven retrospective cohort studies in adults. 41,42,[53][54][55][56][57] We excluded one further study in children with cancer, 52 as none of the required outcomes was reported in children with CVC removal and retention.…”
Section: Resultsmentioning
confidence: 99%
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“…From the 38 potentially eligible studies (see Figure 5), we found one systematic review 43 and eight retrospective cohort studies in children. [45][46][47][48][49][50][51][52] We excluded seven retrospective cohort studies in adults. 41,42,[53][54][55][56][57] We excluded one further study in children with cancer, 52 as none of the required outcomes was reported in children with CVC removal and retention.…”
Section: Resultsmentioning
confidence: 99%
“…71 We included seven retrospective cohort studies that reported the association between CVC removal and risk of death, complications or recurrent infection in children (see Table 11). [45][46][47][48][49][50][51] The studies involved different patient groups (four studies were confined to neonates) [47][48][49][50] and different types of bloodstream infection (five studies were restricted to specific organisms), 45,[47][48][49]51 making it difficult to assess consistency of results. None of the studies presented results adjusted for severity of illness, but three studies, one of bloodstream infection due to Enterobacteriaceae, 47 one in neonates with coagulase-negative staphylococcal bloodstream infection 49 and one in neonates with candidaemia, 48 were from the same team of investigators and reported similar baseline characteristics in babies according to CVC removal or retention.…”
Section: Resultsmentioning
confidence: 99%
“…17,29,[34][35][36][37][38][39][40][41] A taxa de infeção é mais alta em recém-nascidos e no caso de cateteres de múltiplo lúmen. A incidência de complicações infeciosas é substancialmente maior na NP, quer seja por PICC quer seja por CVC, com taxas até seis vezes superiores na síndroma de intestino curto devido à translocação bacteriana.…”
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